Search Results - "Hoelter, Sabine"

Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6 by Poët, Mallorie, Kornak, Uwe, Schweizer, Michaela, Zdebik, Anselm A, Scheel, Olaf, Hoelter, Sabine, Wurst, Wolfgang, Schmitt, Anja, Fuhrmann, Jens C, Planells-Cases, Rosa, Mole, Sara E, Hübner, Christian A, Jentsch, Thomas J

“…Mammalian CLC proteins function as Cl − channels or as electrogenic Cl − /H + exchangers and are present in the plasma membrane and intracellular vesicles. We…”
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Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain by Stroo, Esther, Janssen, Leen, Sin, Olga, Hogewerf, Wytse, Koster, Mirjam, Harkema, Liesbeth, Youssef, Sameh A, Beschorner, Natalie, Wolters, Anouk Hg, Bakker, Bjorn, Becker, Lore, Garrett, Lilian, Marschall, Susan, Hoelter, Sabine M, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Thathiah, Amantha, Foijer, Floris, van de Sluis, Bart, van Deursen, Jan, Jucker, Matthias, de Bruin, Alain, Nollen, Ellen Aa

“…In age-related neurodegenerative diseases, like Alzheimer's and Parkinson's, disease-specific proteins become aggregation-prone and form amyloid-like deposits…”
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"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour? by Hoelter, Sabine M, Dalke, Claudia, Kallnik, Magdalena, Becker, Lore, Horsch, Marion, Schrewe, Anja, Favor, Jack, Klopstock, Thomas, Beckers, Johannes, Ivandic, Boris, Gailus-Durner, Valérie, Fuchs, Helmut, Hrabé de Angelis, Martin, Graw, Jochen, Wurst, Wolfgang

“…It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely…”
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Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes by Rubio-Aliaga, Isabel, Przemeck, Gerhard K H, Fuchs, Helmut, Gailus-Durner, Valérie, Adler, Thure, Hans, Wolfgang, Horsch, Marion, Rathkolb, Birgit, Rozman, Jan, Schrewe, Anja, Wagner, Sibylle, Hoelter, Sabine M, Becker, Lore, Klopstock, Thomas, Wurst, Wolfgang, Wolf, Eckhard, Klingenspor, Martin, Ivandic, Boris T, Busch, Dirk H, Beckers, Johannes, Hrabé de Angelis, Martin

“…The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during…”
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Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation by Sabrautzki, Sibylle, Sandholzer, Michael A, Lorenz-Depiereux, Bettina, Brommage, Robert, Przemeck, Gerhard, Vargas Panesso, Ingrid L, Vernaleken, Alexandra, Garrett, Lillian, Baron, Katharina, Yildirim, Ali O, Rozman, Jan, Rathkolb, Birgit, Gau, Christine, Hans, Wolfgang, Hoelter, Sabine M, Marschall, Susan, Stoeger, Claudia, Becker, Lore, Fuchs, Helmut, Gailus-Durner, Valerie, Klingenspor, Martin, Klopstock, Thomas, Lengger, Christoph, Stefanie, Leuchtenberger, Wolf, Eckhard, Strom, Tim M, Wurst, Wolfgang, de Angelis, Martin Hrabě

“…Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a…”
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Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse by Klopstock, Thomas, Wurst, Wolfgang, Galy, Bruno, Ferring, Dunja, Becker, Lore, Kaden, Sylvia, Hölter, Sabine M, Gröne, Hermann-Josef, Hentze, Matthias W

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CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice by Shimokawa, Noriaki, Haglund, Kaisa, Hölter, Sabine M, Grabbe, Caroline, Kirkin, Vladimir, Koibuchi, Noriyuki, Schultz, Christian, Rozman, Jan, Hoeller, Daniela, Qiu, Chun-Hong, Londoño, Marina B, Ikezawa, Jun, Jedlicka, Peter, Stein, Birgit, Schwarzacher, Stephan W, Wolfer, David P, Ehrhardt, Nicole, Heuchel, Rainer, Nezis, Ioannis, Brech, Andreas, Schmidt, Mirko H H, Fuchs, Helmut, Gailus-Durner, Valerie, Klingenspor, Martin, Bogler, Oliver, Wurst, Wolfgang, Deller, Thomas, de Angelis, Martin Hrabé, Dikic, Ivan

“…Despite extensive investigations of Cbl‐interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its…”
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Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome by Maity-Kumar, Gandhari, Ständer, Lisa, DeAngelis, Meri, Lee, Sooyeon, Molenaar, Anna, Becker, Lore, Garrett, Lillian, Amerie, Oana V., Hoelter, Sabine M., Wurst, Wolfgang, Fuchs, Helmut, Feuchtinger, Annette, Gailus-Durner, Valerie, Garcia-Caceres, Cristina, Othman, Ahmed E., Brockmann, Caroline, Schöffling, Vanessa I., Beiser, Katja, Krude, Heiko, Mroz, Piotr A., Hofmann, Susanna, Tuckermann, Jan, DiMarchi, Richard D., Hrabe de Angelis, Martin, Tschöp, Matthias H., Pfluger, Paul T., Müller, Timo D.

“…The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease caused by dysfunctional central thyroid hormone transport due to functional loss of the…”
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Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice by Kallnik, Magdalena, Elvert, Ralf, Ehrhardt, Nicole, Kissling, Daniela, Mahabir, Esther, Welzl, Gerd, Faus-Kessler, Theresa, de Angelis, Martin Hrabé, Wurst, Wolfgang, Schmidt, Jörg, Hölter, Sabine M

“…Housing conditions are known to influence laboratory animal behavior. However, it is not known whether housing mice in individually ventilated cages (IVCs) to…”
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Digital tools of analysis and data integration facilitate synergy between mouse and human brain research and enable translation by Hölter, Sabine M., Garrett, Lillian, Bludau, Sebastian, Amunts, Katrin

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A Pathophysiological Intersection of Diabetes and Alzheimer's Disease by Čater, Maša, Hölter, Sabine M

“…Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although…”
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Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders by Blanco, Sandra, Dietmann, Sabine, Flores, Joana V, Hussain, Shobbir, Kutter, Claudia, Humphreys, Peter, Lukk, Margus, Lombard, Patrick, Treps, Lucas, Popis, Martyna, Kellner, Stefanie, Hölter, Sabine M, Garrett, Lillian, Wurst, Wolfgang, Becker, Lore, Klopstock, Thomas, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabĕ de Angelis, Martin, Káradóttir, Ragnhildur T, Helm, Mark, Ule, Jernej, Gleeson, Joseph G, Odom, Duncan T, Frye, Michaela

“…Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post‐transcriptional…”
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Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis by Beckervordersandforth, Ruth, Ebert, Birgit, Schäffner, Iris, Moss, Jonathan, Fiebig, Christian, Shin, Jaehoon, Moore, Darcie L., Ghosh, Laboni, Trinchero, Mariela F., Stockburger, Carola, Friedland, Kristina, Steib, Kathrin, von Wittgenstein, Julia, Keiner, Silke, Redecker, Christoph, Hölter, Sabine M., Xiang, Wei, Wurst, Wolfgang, Jagasia, Ravi, Schinder, Alejandro F., Ming, Guo-li, Toni, Nicolas, Jessberger, Sebastian, Song, Hongjun, Lie, D. Chichung

“…Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of…”
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Improving biomedical research by automated behaviour monitoring in the animal home cage - action needed for networking by Hölter, Sabine M, Wells, Sara, Voikar, Vootele

“…The key goal in biomedical research is a better understanding of disease aetiologies, which ideally results in strategies and recommendations for the…”
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A rationale for considering heart/brain axis control in neuropsychiatric disease by Garrett, Lillian, Trümbach, Dietrich, Spielmann, Nadine, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabě de Angelis, Martin, Hölter, Sabine M.

“…Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker…”
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Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation by Deng, Tao, Postnikov, Yuri, Zhang, Shaofei, Garrett, Lillian, Becker, Lore, Rácz, Ildikó, Hölter, Sabine M, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Bustin, Michael

“…An interplay between the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biological significance of this interplay is…”
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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss by Schludi, Martin H., Becker, Lore, Garrett, Lillian, Gendron, Tania F., Zhou, Qihui, Schreiber, Franziska, Popper, Bastian, Dimou, Leda, Strom, Tim M., Winkelmann, Juliane, von Thaden, Anne, Rentzsch, Kristin, May, Stephanie, Michaelsen, Meike, Schwenk, Benjamin M., Tan, Jing, Schoser, Benedikt, Dieterich, Marianne, Petrucelli, Leonard, Hölter, Sabine M., Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Klopstock, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…Translation of the expanded (ggggcc) n repeat in C9orf72 patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant…”
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Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ by Hönes, Georg Sebastian, Geist, Daniela, Wenzek, Christina, Pfluger, Paul Thomas, Müller, Timo Dirk, Aguilar-Pimentel, Juan Antonio, Amarie, Oana Veronica, Becker, Lore, Dragano, Natalia, Garrett, Lillian, Hölter, Sabine Maria, Rathkolb, Birgit, Rozman, Jan, Spielmann, Nadine, Treise, Irina, Wolf, Eckhard, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Führer, Dagmar, Moeller, Lars Christian

“…Abstract Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH…”
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A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice by Leu, Chia-Luen, Lam, Daniel D, Salminen, Aaro V, Wefers, Benedikt, Becker, Lore, Garrett, Lillian, Rozman, Jan, Wurst, Wolfgang, Hrabě de Angelis, Martin, Hölter, Sabine M, Winkelmann, Juliane, Williams, Rhîannan H

“…Abstract Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To…”
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Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency by Schriever, Sonja C, Zimprich, Annemarie, Pfuhlmann, Katrin, Baumann, Peter, Giesert, Florian, Klaus, Valentina, Kabra, Dhiraj G, Hafen, Ulrich, Romanov, Artem, Tschöp, Matthias H, Wurst, Wolfgang, Conrad, Marcus, Hölter, Sabine M, Vogt Weisenhorn, Daniela, Pfluger, Paul T

“…Graphical abstract…”
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