Search Results - "Hoekstra, A. G."

Where do the platelets go? A simulation study of fully resolved blood flow through aneurysmal vessels by Mountrakis, L., Lorenz, E., Hoekstra, A. G.

“…Despite the importance of platelets in the formation of a thrombus, their transport in complex flows has not yet been studied in detail. In this paper we…”
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Performance evaluation of a parallel sparse lattice Boltzmann solver by Axner, L., Bernsdorf, J., Zeiser, T., Lammers, P., Linxweiler, J., Hoekstra, A.G.

“…We develop a performance prediction model for a parallelized sparse lattice Boltzmann solver and present performance results for simulations of flow in a…”
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A framework for multi-scale modelling by Chopard, B., Borgdorff, Joris, Hoekstra, A. G.

“…We review a methodology to design, implement and execute multi-scale and multi-science numerical simulations. We identify important ingredients of multi-scale…”
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Optical and non‐optical methods for detection and characterization of microparticles and exosomes by VAN DER POL, E., HOEKSTRA, A. G., STURK, A., OTTO, C., VAN LEEUWEN, T. G., NIEUWLAND, R.

“…Microparticles and exosomes are cell‐derived microvesicles present in body fluids that play a role in coagulation, inflammation, cellular homeostasis and…”
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Mesoscopic simulations of systolic flow in the human abdominal aorta by Artoli, A.M., Hoekstra, A.G., Sloot, P.M.A.

“…The complex nature of blood flow in the human arterial system is still gaining more attention, as it has become clear that cardiovascular diseases localize in…”
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Semi-intrusive multiscale metamodelling uncertainty quantification with application to a model of in-stent restenosis by Nikishova, A, Veen, L, Zun, P, Hoekstra, A G

“…We explore the efficiency of a semi-intrusive uncertainty quantification (UQ) method for multiscale models as proposed by us in an earlier publication. We…”
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On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation by Józsa, T. I., Padmos, R. M., El-Bouri, W. K., Hoekstra, A. G., Payne, S. J.

“…Computational physiological models are promising tools to enhance the design of clinical trials and to assist in decision making. Organ-scale haemodynamic…”
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Influence of stagnant zones on transient and asymptotic dispersion in macroscopically homogeneous porous media by Kandhai, D, Hlushkou, D, Hoekstra, A G, Sloot, P M A, Van As, H, Tallarek, U

“…The role of stagnant zones in hydrodynamic dispersion is studied for creeping flow through a fixed bed of spherical permeable particles, covering several…”
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Scaling of shear-induced diffusion and clustering in a blood-like suspension by Mountrakis, L., Lorenz, E., Hoekstra, A. G.

“…The transport of cells and substances in dense suspensions like blood heavily depends on the microstructure and the dynamics arising from their interactions…”
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Uncertainty quantification patterns for multiscale models by Ye, D, Veen, L, Nikishova, A, Lakhlili, J, Edeling, W, Luk, O O, Krzhizhanovskaya, V V, Hoekstra, A G

“…Uncertainty quantification (UQ) is a key component when using computational models that involve uncertainties, e.g. in decision-making scenarios. In this work,…”
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Cell-resolved blood flow simulations of saccular aneurysms: effects of pulsatility and aspect ratio by Czaja, B., Závodszky, G., Azizi Tarksalooyeh, V., Hoekstra, A. G.

“…We study the effect of pulsatile flow on the transport of red blood cells (RBCs) and platelets into aneurysm geometries with varying dome-to-neck aspect ratios…”
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Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer by van Rooij, B J M, Závodszky, G, Azizi Tarksalooyeh, V W, Hoekstra, A G

“…Computer simulations were performed to study the transport of red blood cells and platelets in high shear flows, mimicking earlier published experiments in…”
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A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke by Józsa, T I, Padmos, R M, Samuels, N, El-Bouri, W K, Hoekstra, A G, Payne, S J

“…The advancement of ischaemic stroke treatment relies on resource-intensive experiments and clinical trials. In order to improve ischaemic stroke treatments,…”
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Haemodynamic flow conditions at the initiation of high-shear platelet aggregation: a combined in vitro and cellular in silico study by van Rooij, B J M, Závodszky, G, Hoekstra, A G, Ku, D N

“…The influence of the flow environment on platelet aggregation is not fully understood in high-shear thrombosis. The objective of this study is to investigate…”
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Lattice-Boltzmann hydrodynamics on parallel systems by Kandhai, D., Koponen, A., Hoekstra, A.G., Kataja, M., Timonen, J., Sloot, P.M.A.

“…Realistic lattice-Boltzmann simulations often require large amounts of computational resources and are therefore executed on parallel systems. Generally,…”
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Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments by Zun, P. S., Narracott, A. J., Chiastra, C., Gunn, J., Hoekstra, A. G.

“…Background Coronary artery restenosis is an important side effect of percutaneous coronary intervention. Computational models can be used to better understand…”
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Cellular Automata Simulations on a FPGA cluster by Murtaza, S., Hoekstra, A.G., Sloot, P.M.A.

“…The emergence of multicore architectures and the chip industry’s plan to roll out hundreds of cores per die sometime in the near future might have triggered…”
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The Moment Propagation Method for Advection–Diffusion in the Lattice Boltzmann Method: Validation and Péclet Number Limits by Merks, R.M.H., Hoekstra, A.G., Sloot, P.M.A.

“…We numerically validate the moment propagation method for advection–diffusion in a lattice Boltzmann simulation against the analytic Taylor–Aris prediction for…”
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A cell-based mechanical model of coronary artery tunica media by Melnikova, N. B., Svitenkov, A. I., Hose, D. R., Hoekstra, A. G.

“…A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal…”
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Performance of distributed multiscale simulations by Borgdorff, J., Ben Belgacem, M., Bona-Casas, C., Fazendeiro, L., Groen, D., Hoenen, O., Mizeranschi, A., Suter, J. L., Coster, D., Coveney, P. V., Dubitzky, W., Hoekstra, A. G., Strand, P., Chopard, B.

“…Multiscale simulations model phenomena across natural scales using monolithic or component-based code, running on local or distributed resources. In this work,…”
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