Search Results - "Hoek, Robert M."

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions by Koning, Nathalie, Swaab, Dick F, Hoek, Robert M, Huitinga, Inge

“…CD200 is a membrane glycoprotein that suppresses immune activity via its receptor, CD200R. CD200-CD200R interactions have recently been considered to…”
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Phenotyping primary human microglia: Tight regulation of LPS responsiveness by Melief, Jeroen, Koning, Nathalie, Schuurman, Karianne G., Van De Garde, Martijn D. B., Smolders, Joost, Hoek, Robert M., Van Eijk, Marco, Hamann, Jörg, Huitinga, Inge

“…Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to…”
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Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis by Broderick, Cathryn, Hoek, Robert M., Forrester, John V., Liversidge, Janet, Sedgwick, Jonathon D., Dick, Andrew D.

“…Recent evidence supports the notion that tissue OX2 (CD200) constitutively provides down-regulatory signals to myeloid-lineage cells via CD200-receptor…”
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GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors by Aartsen, Wendy M, van Cleef, Koen W R, Pellissier, Lucie P, Hoek, Robert M, Vos, Rogier M, Blits, Bas, Ehlert, Erich M E, Balaggan, Kamaljit S, Ali, Robin R, Verhaagen, Joost, Wijnholds, Jan

“…Müller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire…”
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Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation by Ruuls, Sigrid R, Hoek, Robert M, Ngo, Vu N, McNeil, Tom, Lucian, Linda A, Janatpour, Mary J, Körner, Heinrich, Scheerens, Heleen, Hessel, Edith M, Cyster, Jason G, McEvoy, Leslie M, Sedgwick, Jonathon D

“…Mice without secreted TNF but with functional, normally regulated and expressed membrane-bound TNF (memTNF Δ/Δ mice) were created by knocking-in the…”
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Specific tools for targeting and expression in Müller glial cells by Pellissier, Lucie P, Hoek, Robert M, Vos, Rogier M, Aartsen, Wendy M, Klimczak, Ryan R, Hoyng, Stefan A, Flannery, John G, Wijnholds, Jan

“…Despite their physiological roles, Müller glial cells are involved directly or indirectly in retinal disease pathogenesis and are an interesting target for…”
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The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes by Matmati, Mourad, Pouwels, Walter, Bruggen, Robin, Jansen, Machiel, Hoek, Robert M., Verhoeven, Arthur J., Hamann, Jörg

“…EMR3 is a member of the epidermal growth factor‐seven‐transmembrane (EGF‐TM7) family of adhesion class TM7 receptors. This family also comprises CD97, EMR1,…”
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A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense by Veninga, Henrike, Hoek, Robert M, de Vos, Alex F, de Bruin, Alex M, An, Feng-Qi, van der Poll, Tom, van Lier, René A W, Medof, M Edward, Hamann, Jörg

“…In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this…”
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Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions by Koning, Nathalie, Bö, Lars, Hoek, Robert M., Huitinga, Inge

“…Objective Inflammatory and demyelinating activity of activated resident macrophages (microglia) and recruited blood‐borne macrophages are considered crucial in…”
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Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55 by Karpus, Olga N, Veninga, Henrike, Hoek, Robert M, Flierman, Dennis, van Buul, Jaap D, Vandenakker, Corianne C, vanBavel, Ed, Medof, M Edward, van Lier, René A W, Reedquist, Kris A, Hamann, Jörg

“…Adhesion G protein-coupled receptors (aGPCRs) are two-subunit molecules, consisting of an adhesive extracellular α subunit that couples noncovalently to a…”
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GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo by van Olffen, Ronald W, Koning, Nathalie, van Gisbergen, Klaas P. J. M, Wensveen, Felix M, Hoek, Robert M, Boon, Louis, Hamann, Jorg, van Lier, Rene A. W, Nolte, Martijn A

“…Glucocorticoid-induced TNF receptor family-related protein (GITR) is expressed on activated and regulatory T cells, but its role on these functionally opposing…”
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The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes by Rijkers, Eva S.K., de Ruiter, Talitha, Baridi, Ajoeb, Veninga, Henrike, Hoek, Robert M., Meyaard, Linde

“…To ensure an adequate response against pathogens and prevent unwanted self-reactivity, immune cells need to functionally express both activating and inhibitory…”
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Lack of CD200 Enhances Pathological T Cell Responses during Influenza Infection by Rygiel, Tomasz P, Rijkers, Eva S. K, de Ruiter, Talitha, Stolte, Ellen H, van der Valk, Martin, Rimmelzwaan, Guus F, Boon, Louis, van Loon, Anton M, Coenjaerts, Frank E, Hoek, Robert M, Tesselaar, Kiki, Meyaard, Linde

“…Influenza virus infection can be accompanied by life-threatening immune pathology most likely due to excessive antiviral responses. Inhibitory immune receptors…”
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Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation by Koning, Nathalie, van Eijk, Marco, Pouwels, Walter, Brouwer, Michael S.M., Voehringer, David, Huitinga, Inge, Hoek, Robert M., Raes, Geert, Hamann, Jörg

“…Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro…”
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Down-Regulation of the Macrophage Lineage through Interaction with OX2 (CD200) by Hoek, Robert M., Ruuls, Sigrid R., Murphy, Craig A., Wright, Gavin J., Goddard, Ruth, Zurawski, Sandra M., Blom, Bianca, Homola, Margit E., Streit, Wolfgang J., Brown, Marion H., Barclay, A. Neil, Sedgwick, Jonathon D.

“…OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200,…”
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Restoring immune suppression in the multiple sclerosis brain by Koning, Nathalie, Uitdehaag, Bernard M J, Huitinga, Inge, Hoek, Robert M

“…Multiple sclerosis is a very disabling inflammatory demyelinating disease of the brain of unknown etiology. Current therapies can reduce new lesion development…”
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Analysis of CD97 Expression and Manipulation: Antibody Treatment but Not Gene Targeting Curtails Granulocyte Migration by Veninga, Henrike, Becker, Susann, Hoek, Robert M, Wobus, Manja, Wandel, Elke, van der Kaa, Jos, van der Valk, Martin, de Vos, Alex F, Haase, Hannelore, Owens, Bronwyn, van der Poll, Tom, van Lier, Rene A. W, Verbeek, J. Sjef, Aust, Gabriela, Hamann, Jorg

“…The heptahelical receptor CD97 is a defining member of the EGF-TM7 family of adhesion class receptors. In both humans and mice, CD97 isoforms are expressed…”
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Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function by Wright, Gavin J, Puklavec, Michael J, Willis, Antony C, Hoek, Robert M, Sedgwick, Jonathon D, Brown, Marion H, Barclay, A.Neil

“…The OX2 membrane glycoprotein (CD200) is expressed on a broad range of tissues including lymphoid cells, neurons, and endothelium. We report the…”
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Altered Gene Expression in the Host Brain Caused by a Trematode Parasite: Neuropeptide Genes are Preferentially Affected during Parasitosis by Hoek, Robert M., Van Kesteren, Ronald E., Smit, August B., De Jong-Brink, Marijke, Wijnand P. M. Geraerts

“…Schistosome parasites adjust the physiology and behavior of their intermediate molluscan hosts to their own benefit. Previous studies demonstrated effects of…”
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DAP12-Deficient Mice Fail to Develop Autoimmunity Due to Impaired Antigen Priming by Bakker, Alexander B.H., Hoek, Robert M., Cerwenka, Adelheid, Blom, Bianca, Lucian, Linda, McNeil, Tom, Murray, Richard, Phillips, Joseph H., Sedgwick, Jonathon D., Lanier, Lewis L.

“…DAP12 is an ITAM-bearing membrane adaptor molecule implicated in the activation of NK and myeloid cells. In mice rendered DAP12 deficient by targeted gene…”
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