Search Results - "Hoek, Keith S"

Cancer stem cells versus phenotype-switching in melanoma by Hoek, Keith S., Goding, Colin R.

“…Summary Tumours comprise multiple phenotypically distinct subpopulations of cells, some of which are proposed to possess stem cell‐like properties, being able…”
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In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States by HOEK, Keith S, EICHHOFF, Ossia M, SCHLEGEL, Natalie C, DÖBBELING, Udo, KOBERT, Nikita, SCHAERER, Leo, HEMMI, Silvio, DUMMER, Reinhard

“…Metastatic melanoma represents a complex and heterogeneous disease for which there are no therapies to improve patient survival. Recent expression profiling of…”
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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness by Carreira, Suzanne, Goodall, Jane, Denat, Laurence, Rodriguez, Mercedes, Nuciforo, Paolo, Hoek, Keith S, Testori, Alessandro, Larue, Lionel, Goding, Colin R

“…It is widely held that cells with metastatic properties such as invasiveness and expression of matrix metalloproteinases arise through the stepwise…”
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Systematic classification of melanoma cells by phenotype-specific gene expression mapping by Widmer, Daniel S., Cheng, Phil F., Eichhoff, Ossia M., Belloni, Benedetta C., Zipser, Marie C., Schlegel, Natalie C., Javelaud, Delphine, Mauviel, Alain, Dummer, Reinhard, Hoek, Keith S.

“…Summary There is growing evidence that the metastatic spread of melanoma is driven not by a linear increase in tumorigenic aggressiveness, but rather by…”
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Novel MITF targets identified using a two-step DNA microarray strategy by Hoek, Keith S., Schlegel, Natalie C., Eichhoff, Ossia M., Widmer, Daniel S., Praetorius, Christian, Einarsson, Steingrimur O., Valgeirsdottir, Sigridur, Bergsteinsdottir, Kristin, Schepsky, Alexander, Dummer, Reinhard, Steingrimsson, Eirikur

“…Summary Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent advances in our understanding of the disease at the molecular level…”
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GLI2-Mediated Melanoma Invasion and Metastasis by Alexaki, Vasileia-Ismini, Javelaud, Delphine, Van Kempen, Leon C. L., Mohammad, Khalid S., Dennler, Sylviane, Luciani, Flavie, Hoek, Keith S., Juàrez, Patricia, Goydos, James S., Fournier, Pierrick J., Sibon, Claire, Bertolotto, Corine, Verrecchia, Franck, Saule, Simon, Delmas, Veronique, Ballotti, Robert, Larue, Lionel, Saiag, Philippe, Guise, Theresa A., Mauviel, Alain

“…Background The transforming growth factor-β (TGF-β) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in…”
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CT-X antigen expression in human breast cancer by Grigoriadis, Anita, Caballero, Otavia L, Hoek, Keith S, da Silva, Leonard, Chen, Yao-Tseng, Shin, Sandra J, Jungbluth, Achim A, Miller, Lance D, Clouston, David, Cebon, Jonathan, Old, Lloyd J, Lakhani, Sunil R, Simpson, Andrew J.G, Neville, A. Munro

“…Cancer/testis (CT) genes are predominantly expressed in human germ line cells, but not somatic tissues, and frequently become activated in different cancer…”
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Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells by O'Connell, Michael P., Fiori, Jennifer L., Kershner, Emily K., Frank, Brittany P., Indig, Fred E., Taub, Dennis D., Hoek, Keith S., Weeraratna, Ashani T.

“…Heparan sulfate proteoglycans (HSPGs) are important modulators for optimizing signal transduction of many pathways, including the Wnt pathways. We demonstrate…”
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A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status by Zipser, Marie C., Eichhoff, Ossia M., Widmer, Daniel S., Schlegel, Natalie C., Schoenewolf, Nicola L., Stuart, Darrin, Liu, Weihua, Gardner, Humphrey, Smith, Paul D., Nuciforo, Paolo, Dummer, Reinhard, Hoek, Keith S.

“…Summary Oncogenic mutations within the MAPK pathway are frequent in melanoma, and targeting of MAPK signaling has yielded spectacular responses in a…”
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A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion by Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., Nikiforov, Mikhail A.

“…Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here,…”
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Wnt5A Activates the Calpain-Mediated Cleavage of Filamin A by O'Connell, Michael P., Fiori, Jennifer L., Baugher, Katherine M., Indig, Fred E., French, Amanda D., Camilli, Tura C., Frank, Brittany P., Earley, Rachel, Hoek, Keith S., Hasskamp, Joanne H., George Elias, E., Taub, Dennis D., Bernier, Michel, Weeraratna, Ashani T.

“…We have previously shown that Wnt5A and ROR2, an orphan tyrosine kinase receptor, interact to mediate melanoma cell motility. In other cell types, this can…”
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Filamin A Modulates Kinase Activation and Intracellular Trafficking of Epidermal Growth Factor Receptors in Human Melanoma Cells by Fiori, Jennifer L, Zhu, Tie-Nian, O'Connell, Michael P, Hoek, Keith S, Indig, Fred E, Frank, Brittany P, Morris, Christa, Kole, Sutapa, Hasskamp, Joanne, Elias, George, Weeraratna, Ashani T, Bernier, Michel

“…The actin-binding protein filamin A (FLNa) affects the intracellular trafficking of various classes of receptors and has a potential role in oncogenesis…”
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Loss of full length CtBP1 expression enhances the invasive potential of human melanoma by Winklmeier, Andreas, Poser, Ina, Hoek, Keith S, Bosserhoff, Anja K

“…The C-terminal binding protein 1 (CtBP1) is a known co-repressor of gene transcription. We recently revealed that CtBP1 expression is lost in melanoma cells…”
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hnRNP A2 Selectively Binds the Cytoplasmic Transport Sequence of Myelin Basic Protein mRNA by Hoek, Keith S, Kidd, Grahame J, Carson, John H, Smith, Ross

“…Segregation of mRNAs in the cytoplasm of polar cells has been demonstrated for proteins involved in Xenopus and Drosophila oogenesis, and for some proteins in…”
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Heterogeneous Nuclear Ribonucleoprotein A3, a Novel RNA Trafficking Response Element-binding Protein by Ma, Alice S.W., Moran-Jones, Kim, Shan, Jianguo, Munro, Trent P., Snee, Mark J., Hoek, Keith S., Smith, Ross

“…The cis- acting response element, A2RE, which is sufficient for cytoplasmic mRNA trafficking in oligodendrocytes, binds a small group of rat brain proteins…”
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Hypoxia Contributes to Melanoma Heterogeneity by Triggering HIF1α-Dependent Phenotype Switching by Widmer, Daniel S., Hoek, Keith S., Cheng, Phil F., Eichhoff, Ossia M., Biedermann, Thomas, Raaijmakers, Marieke I.G., Hemmi, Silvio, Dummer, Reinhard, Levesque, Mitchell P.

“…We have previously reported a model for melanoma progression in which oscillation between melanoma cell phenotypes characterized by invasion or proliferation…”
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Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching by Eichhoff, Ossia M., Weeraratna, Ashani, Zipser, Marie C., Denat, Laurence, Widmer, Daniel S., Xu, Mai, Kriegl, Lydia, Kirchner, Thomas, Larue, Lionel, Dummer, Reinhard, Hoek, Keith S.

“…Summary Recent observations suggest that melanoma cells drive disease progression by switching back and forth between phenotypic states of proliferation and…”
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E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells by Lobos-González, Lorena, Aguilar, Lorena, Diaz, Jorge, Diaz, Natalia, Urra, Hery, Torres, Vicente A., Silva, Veronica, Fitzpatrick, Christopher, Lladser, Alvaro, Hoek, Keith S., Leyton, Lisette, Quest, Andrew F. G.

“…Summary The role of caveolin‐1 (CAV1) in cancer is highly controversial. CAV1 suppresses genes that favor tumor development, yet also promotes focal adhesion…”
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MITF: the power and the glory by Hoek, Keith S.

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GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells by Javelaud, Delphine, Alexaki, Vasileia-Ismini, Pierrat, Marie-Jeanne, Hoek, Keith S., Dennler, Sylviane, Van Kempen, Leon, Bertolotto, Corine, Ballotti, Robert, Saule, Simon, Delmas, Véronique, Mauviel, Alain

“…Summary We recently identified GLI2, the most active of GLI transcription factors, as a direct TGF‐β/SMAD target, whose expression in melanoma cells is…”
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