Search Results - "Hoehn, L"

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth by Kashatus, Jennifer A., Nascimento, Aldo, Myers, Lindsey J., Sher, Annie, Byrne, Frances L., Hoehn, Kyle L., Counter, Christopher M., Kashatus, David F.

“…Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to…”
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Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance by Lira, Vitor A., Okutsu, Mitsuharu, Zhang, Mei, Greene, Nicholas P., Laker, Rhianna C., Breen, David S., Hoehn, Kyle L., Yan, Zhen

“…Pathological and physiological stimuli, including acute exercise, activate autophagy; however, it is unknown whether exercise training alters basal levels of…”
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The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis by Laker, Rhianna C, Taddeo, Evan P, Akhtar, Yasir N, Zhang, Mei, Hoehn, Kyle L, Yan, Zhen

“…The mitochondrial permeability transition pore (mPTP) is a key regulator of mitochondrial function that has been implicated in the pathogenesis of metabolic…”
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism by Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.

“…Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models…”
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Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice by Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.

“…Obesity is a health problem affecting more than 40% of US adults and 13% of the global population. Anti-obesity treatments including diet, exercise, surgery…”
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Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer by Chen, Bei Jun, Byrne, Frances L., Takenaka, Konii, Modesitt, Susan C., Olzomer, Ellen M., Mills, James D., Farrell, Rhonda, Hoehn, Kyle L., Janitz, Michael

“…Endometrial cancer is the most common gynecological malignancy in the developed world. It is the fifth most common cancer and accounts for 4.8% of all cancers…”
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Insulin resistance is a cellular antioxidant defense mechanism by Hoehn, Kyle L, Salmon, Adam B, Hohnen-Behrens, Cordula, Turner, Nigel, Hoy, Andrew J, Maghzal, Ghassan J, Stocker, Roland, Van Remmen, Holly, Kraegen, Edward W, Cooney, Greg J, Richardson, Arlan R, James, David E

“…We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an…”
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Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27 by Rastogi, Priya, Anderson, Stewart J, Bear, Harry D, Geyer, Charles E, Kahlenberg, Morton S, Robidoux, André, Margolese, Richard G, Hoehn, James L, Vogel, Victor G, Dakhil, Shaker R, Tamkus, Deimante, King, Karen M, Pajon, Eduardo R, Wright, Mary Johanna, Robert, Jean, Paik, Soonmyung, Mamounas, Eleftherios P, Wolmark, Norman

“…National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-18 was designed to determine whether four cycles of doxorubicin and cyclophosphamide…”
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Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice by Byrne, Frances L, Olzomer, Ellen M, Brink, Robert, Hoehn, Kyle L

“…Glucose transporter 6 (GLUT6) is a member of the facilitative glucose transporter family. GLUT6 is upregulated in several cancers but is not widely expressed…”
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Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein by Park, Daeho, Han, Claudia Z., Elliott, Michael R., Kinchen, Jason M., Trampont, Paul C., Das, Soumita, Collins, Sheila, Lysiak, Jeffrey J., Hoehn, Kyle L., Ravichandran, Kodi S.

“…How phagocytes keep their appetite When a phagocyte engulfs a dying cell, it essentially doubles its cellular contents, yet phagocytes are capable of ingesting…”
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Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma by Byrne, Frances L, Olzomer, Ellen M, Lolies, Nina, Hoehn, Kyle L, Wegner, Marthe-Susanna

“…Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or…”
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Analysis of the circular RNA transcriptome in endometrial cancer by Chen, Bei Jun, Byrne, Frances L, Takenaka, Konii, Modesitt, Susan C, Olzomer, Ellen M, Mills, James D, Farrell, Rhonda, Hoehn, Kyle L, Janitz, Michael

“…Circular RNAs (circRNAs) are a naturally occurring family of non-coding RNA that may regulate gene expression in mammals. circRNAs are more stable than…”
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Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance by Holland, William L., Brozinick, Joseph T., Wang, Li-Ping, Hawkins, Eric D., Sargent, Katherine M., Liu, Yanqi, Narra, Krishna, Hoehn, Kyle L., Knotts, Trina A., Siesky, Angela, Nelson, Don H., Karathanasis, Sotirios K., Fontenot, Greg K., Birnbaum, Morris J., Summers, Scott A.

“…Insulin resistance occurs in 20%–25% of the human population, and the condition is a chief component of type 2 diabetes mellitus and a risk factor for…”
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Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass by Cantley, James, Davenport, Aimee, Vetterli, Laurène, Nemes, Nandor J., Whitworth, P. Tess, Boslem, Ebru, Thai, Le May, Mellett, Natalie, Meikle, Peter J., Hoehn, Kyle L., James, David E., Biden, Trevor J.

“…Aims/hypothesis Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers…”
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Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3) by Knights, Alexander J., Vohralik, Emily J., Houweling, Peter J., Stout, Elizabeth S., Norton, Laura J., Alexopoulos, Stephanie J., Yik, Jinfen. J., Mat Jusoh, Hanapi, Olzomer, Ellen M., Bell-Anderson, Kim S., North, Kathryn N., Hoehn, Kyle L., Crossley, Merlin, Quinlan, Kate G. R.

“…The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However,…”
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Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival by Nelson, Marin E., Lahiri, Sujoy, Chow, Jenny D. Y., Byrne, Frances L., Hargett, Stefan R., Breen, David S., Olzomer, Ellen M., Wu, Lindsay E., Cooney, Gregory J., Turner, Nigel, James, David E., Slack-Davis, Jill K., Lackner, Carolin, Caldwell, Stephen H., Hoehn, Kyle L.

“…The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver tumours, and its upregulation is associated with poor prognosis. Blocking…”
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BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control by Axelrod, Christopher L, King, William T, Davuluri, Gangarao, Noland, Robert C, Hall, Jacob, Hull, Michaela, Dantas, Wagner S, Zunica, Elizabeth RM, Alexopoulos, Stephanie J, Hoehn, Kyle L, Langohr, Ingeborg, Stadler, Krisztian, Doyle, Haylee, Schmidt, Eva, Nieuwoudt, Stephan, Fitzgerald, Kelly, Pergola, Kathryn, Fujioka, Hisashi, Mey, Jacob T, Fealy, Ciaran, Mulya, Anny, Beyl, Robbie, Hoppel, Charles L, Kirwan, John P

“…Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving…”
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Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury by Bajwa, Amandeep, Rosin, Diane L, Chroscicki, Piotr, Lee, Sangju, Dondeti, Krishna, Ye, Hong, Kinsey, Gilbert R, Stevens, Brian K, Jobin, Katarzyna, Kenwood, Brandon M, Hoehn, Kyle L, Lynch, Kevin R, Okusa, Mark D

“…Sphingosine 1-phosphate (S1P), the natural sphingolipid ligand for a family of five G protein- coupled receptors (S1P1-S1P5Rs), regulates cell survival and…”
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Metabolic vulnerabilities in endometrial cancer by Byrne, Frances L, Poon, Ivan K H, Modesitt, Susan C, Tomsig, Jose L, Chow, Jenny D Y, Healy, Marin E, Baker, William D, Atkins, Kristen A, Lancaster, Johnathan M, Marchion, Douglas C, Moley, Kelle H, Ravichandran, Kodi S, Slack-Davis, Jill K, Hoehn, Kyle L

“…Women with metabolic disorders, including obesity and diabetes, have an increased risk of developing endometrial cancer. However, the metabolism of endometrial…”
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Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance by Fazakerley, Daniel J, Chaudhuri, Rima, Yang, Pengyi, Maghzal, Ghassan J, Thomas, Kristen C, Krycer, James R, Humphrey, Sean J, Parker, Benjamin L, Fisher-Wellman, Kelsey H, Meoli, Christopher C, Hoffman, Nolan J, Diskin, Ciana, Burchfield, James G, Cowley, Mark J, Kaplan, Warren, Modrusan, Zora, Kolumam, Ganesh, Yang, Jean Yh, Chen, Daniel L, Samocha-Bonet, Dorit, Greenfield, Jerry R, Hoehn, Kyle L, Stocker, Roland, James, David E

“…Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial…”
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