Sleep‐related breathing disorders impair quality of life in haemodialysis recipients

Background. It is well known that the quality of life of haemodialysis recipients is often severely compromised. So far, the influence of sleep‐related breathing disorders on the quality of life of patients receiving maintenance dialysis has not been evaluated. Methods. Quality of life as assessed b...

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Published in:	Nephrology, dialysis, transplantation Vol. 17; no. 7; pp. 1260 - 1265
Main Authors:	Sanner, Bernd M., Tepel, Martin, Esser, Martina, Klewer, Joerg, Hoehmann‐Riese, Beate, Zidek, Walter, Hellmich, Bernhard
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-07-2002
Subjects:	Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Confidence Intervals dialysis Emergency and intensive care: renal failure. Dialysis management Female Health Status Humans Intensive care medicine Male Medical sciences Middle Aged Quality of Life Regression Analysis Renal Dialysis Respiratory Tract Diseases - physiopathology Respiratory Tract Diseases - psychology sleep Sleep Apnea Syndromes - physiopathology Sleep Wake Disorders - physiopathology Sleep Wake Disorders - psychology Human Extrarenal dialysis Nervous system diseases Hemodialysis Sleep disorder Complication Neurological disorder Quality of life
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Summary:	Background. It is well known that the quality of life of haemodialysis recipients is often severely compromised. So far, the influence of sleep‐related breathing disorders on the quality of life of patients receiving maintenance dialysis has not been evaluated. Methods. Quality of life as assessed by the Medical Outcomes Study Short Form‐36 (SF‐36) and the Nottingham Health Profile Part 1 (NHP1) was determined in 33 patients (20 males, 13 females; median age 66 years (95% CI 22–82)) with end‐stage renal disease treated with haemodialysis. Additionally, polygraphy with a validated eight‐channel ambulatory recording unit was performed. Results. Twenty‐one patients (63.6%) had a clinically significant sleep‐related breathing disorder with a median apnoea/hypopnoea index of 13.3 (6.3–78.1)/h and a median oxygen saturation during sleep of 92.5 (88–97)%. In three out of eight subjective measures of the SF‐36 (vitality, social functioning and mental health) and in one out of six subjective measures of the NHP1 (emotional reactions), patients without sleep‐related breathing disorders had a higher quality of life than patients with this disorder (P<0.05 each). Furthermore, the severity of the sleep‐related breathing disorder as indicated by the apnoea/hypopnoea index significantly correlated with the following quality of life measures: physical functioning, social functioning, role limitation due to physical and emotional problems, general health and vitality (SF‐36), and also with pain, sleep, social isolation and emotional reactions (NHP1) (P<0.05 each). Conclusions. We conclude that sleep‐related breathing disorders independently influence the quality of life of patients receiving maintenance dialysis.
Bibliography:	istex:A1A21AE0ED038A84A662B7799E315ED28D2317B9 PII:1460-2385 ark:/67375/HXZ-JQZZCHVM-8 local:171260 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0931-0509 1460-2385 1460-2385
DOI:	10.1093/ndt/17.7.1260