Search Results - "Hoehe, Margret R"

Fosmid-based whole genome haplotyping of a HapMap trio child: evaluation of Single Individual Haplotyping techniques by Duitama, Jorge, McEwen, Gayle K., Huebsch, Thomas, Palczewski, Stefanie, Schulz, Sabrina, Verstrepen, Kevin, Suk, Eun-Kyung, Hoehe, Margret R.

“…Determining the underlying haplotypes of individual human genomes is an essential, but currently difficult, step toward a complete understanding of genome…”
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A comprehensively molecular haplotype-resolved genome of a European individual by Suk, Eun-Kyung, McEwen, Gayle K, Duitama, Jorge, Nowick, Katja, Schulz, Sabrina, Palczewski, Stefanie, Schreiber, Stefan, Holloway, Dustin T, McLaughlin, Stephen, Peckham, Heather, Lee, Clarence, Huebsch, Thomas, Hoehe, Margret R

“…Independent determination of both haplotype sequences of an individual genome is essential to relate genetic variation to genome function, phenotype, and…”
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Going digital: how technology use may influence human brains and behavior by Hoehe, Margret R., Thibaut, Florence

“…The digital revolution has changed, and continues to change, our world and our lives. Currently, major aspects of our lives have moved online due to the…”
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Cannabinoids: for better and for worse by Thibaut, Florence, Hoehe, Margret R.

“…The use of cannabis as a drug has undergone a remarkable change of direction: considered as a symbol of countercultures in past decades, it is presently being…”
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Specific attentional dysfunction in adults following early start of cannabis use by EHRENREICH, H, RINN, T, KUNERT, H. J, MOELLER, M. R, POSER, W, SCHILLING, L, GIGERENZER, G, HOEHE, M. R

“…The present study tested the hypothesis that chronic interference by cannabis with endogenous cannabinoid systems during peripubertal development causes…”
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The role of genetics and genomics in clinical psychiatry by Hoehe, Margret R., Morris-Rosendahl, Deborah J.

“…The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of…”
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Significant abundance of cis configurations of coding variants in diploid human genomes by Hoehe, Margret R, Herwig, Ralf, Mao, Qing, Peters, Brock A, Drmanac, Radoje, Church, George M, Huebsch, Thomas

“…Abstract To fully understand human genetic variation and its functional consequences, the specific distribution of variants between the two chromosomal…”
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Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes by Hoehe, Margret R., Church, George M., Lehrach, Hans, Kroslak, Thomas, Palczewski, Stefanie, Nowick, Katja, Schulz, Sabrina, Suk, Eun-Kyung, Huebsch, Thomas

“…To fully understand human biology and link genotype to phenotype, the phase of DNA variants must be known. Here we present a comprehensive analysis of…”
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A Fosmid Pool-Based Next Generation Sequencing Approach to Haplotype-Resolve Whole Genomes by Suk, Eun-Kyung, Schulz, Sabrina, Mentrup, Birgit, Huebsch, Thomas, Duitama, Jorge, Hoehe, Margret R

“…Haplotype resolution of human genomes is essential to describe and interpret genetic variation and its impact on biology and disease. Our approach to…”
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Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations by Branson, Ruth, Potoczna, Natascha, Kral, John G, Lentes, Klaus-Ulrich, Hoehe, Margret R, Horber, Fritz F

“…Mutations in the genes for the melanocortin 4 receptor ( MC4R ), the leptin receptor, and proopiomelanocortin have been identified as potential causes of…”
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A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling by Befort, Katia, Filliol, Dominique, Décaillot, Fabien M., Gavériaux-Ruff, Claire, Hoehe, Margret R., Kieffer, Brigitte L.

“…Large scale sequencing of the human μ-opioid receptor (hMOR) gene has revealed polymorphic mutations that occur within the coding region. We have investigated…”
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Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? by Heid, Iris M, Huth, Cornelia, Loos, Ruth J F, Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S, Ardlie, Kristin, Biebermann, Heike, Bjerregaard, Peter, Boeing, Heiner, Bouchard, Claude, Ciullo, Marina, Cooper, Jackie A, Corella, Dolores, Dina, Christian, Engert, James C, Fisher, Eva, Francès, Francesc, Froguel, Philippe, Hebebrand, Johannes, Hegele, Robert A, Hinney, Anke, Hoehe, Margret R, Hu, Frank B, Hubacek, Jaroslav A, Humphries, Steve E, Hunt, Steven C, Illig, Thomas, Järvelin, Marjo-Riita, Kaakinen, Marika, Kollerits, Barbara, Krude, Heiko, Kumar, Jitender, Lange, Leslie A, Langer, Birgit, Li, Shengxu, Luchner, Andreas, Lyon, Helen N, Meyre, David, Mohlke, Karen L, Mooser, Vincent, Nebel, Almut, Nguyen, Thuy Trang, Paulweber, Bernhard, Perusse, Louis, Qi, Lu, Rankinen, Tuomo, Rosskopf, Dieter, Schreiber, Stefan, Sengupta, Shantanu, Sorice, Rossella, Suk, Anita, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Völzke, Henry, Vimaleswaran, Karani S, Wareham, Nicholas J, Waterworth, Dawn, Yusuf, Salim, Lindgren, Cecilia, McCarthy, Mark I, Lange, Christoph, Hirschhorn, Joel N, Laird, Nan, Wichmann, H-Erich

“…The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were…”
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Sequence variability and candidate gene analysis in complex disease : association of μ opioid receptor gene variation with substance dependence by HOEHE, Margret R, KÖPKE, Karla, WENDEL, Birgit, ROHDE, Klaus, FLACHMEIER, Christina, KIDD, Kenneth K, BERRETTINI, Wade H, CHURCH, George M

“…To analyze candidate genes and establish complex genotype-phenotype relationships against a background of high natural genome sequence variability, we have…”
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Association of a CB1 Cannabinoid Receptor Gene ( CNR1) polymorphism with severe alcohol dependence by Schmidt, Lutz G, Samochowiec, Jerzy, Finckh, Ulrich, Fiszer-Piosik, Ewa, Horodnicki, Jan, Wendel, B, Rommelspacher, Hans, Hoehe, Margret R

“…Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of…”
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Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity by Potoczna, Natascha, Branson, Ruth, Kral, John G., Piec, Grazyna, Steffen, Rudolf, Ricklin, Thomas, Hoehe, Margret R., Lentes, Klaus-Ulrich, Horber, Fritz F.

“…Melanocortin-4 receptor gene ( MC4R) variants are associated with obesity and binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (…”
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Individual variation in response to μ opiate receptor challenge-past, present, and future : a personal history of investigation by HOEHE, Margret R

“…Individual differences in response to addictive substances may provide important clues to the mechanisms underlying drug action, addiction, reward, and…”
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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence by Franke, Petra, Wendel, Birgit, Knapp, Michael, Schwab, Sibylle G., Neef, Daniela, Maier, Wolfgang, Wildenauer, Dieter B., Hoehe, Margret R.

“…Objective. – In a modified case–control association study we tested the assumption that two polymorphisms (A 118G in exon 1 and IVS2+31 in intron 2) of the…”
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beta-2 Adrenergic Receptor Variants Affect Resting Blood Pressure and Agonist-Induced Vasodilation in Young Adult Caucasians by Gratze, Gerfried, Fortin, Jurgen, Labugger, Ralf, Binder, Alexander, Kotanko, Peter, Timmermann, Bernd, Luft, Friedrich C, Hoehe, Margret R, Skrabal, Falko

“…Recent evidence suggests that the prodownregulatory Gly16 allele of the beta-2 adrenergic receptor (beta-2 AR) is associated with essential hypertension in…”
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Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism by Krampe, Henning, Stawicki, Sabina, Hoehe, Margret R., Ehrenreich, Hannelore

“…Alcohol dependence is a frequent, chronic, relapsing, and incurable disease with enormous societal costs. Thus, alcoholism therapy and research into its…”
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Polymorphisms of the β2-adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies by Herrmann, Stefan-Martin, Nicaud, Viviane, Tiret, Laurence, Evans, Alun, Kee, Frank, Ruidavets, Jean-Bernard, Arveiler, Dominique, Luc, Gerald, Morrison, Caroline, Hoehe, Margret R, Paul, Martin, Cambien, François

“…OBJECTIVES The β2-adrenoceptor (ADRB2) plays a pivotal role in signalling in relation to hypertension and obesity. Polymorphisms of the ADRB2 gene have been…”
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