Search Results - "Hoeg, Jeffrey M"

Cumulative Effects of High Cholesterol Levels, High Blood Pressure, and Cigarette Smoking on Carotid Stenosis by Wilson, Peter W.F, Hoeg, Jeffrey M, D'Agostino, Ralph B, Silbershatz, Halit, Belanger, Albert M, Poehlmann, Harold, O'Leary, Daniel, Wolf, Philip A

“…The effect of risk factors such as high levels of serum cholesterol and high-density lipoprotein (HDL) cholesterol, high blood pressure, and cigarette smoking…”
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Transgenic rabbits as models for atherosclerosis research by Brousseau, M.E, Hoeg, J.M

“…Several characteristics of the rabbit make it an excellent model for the study of lipoprotein metabolism and atherosclerosis. New Zealand White (NZW) rabbits…”
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LCAT Modulates Atherogenic Plasma Lipoproteins and the Extent of Atherosclerosis Only in the Presence of Normal LDL Receptors in Transgenic Rabbits by Brousseau, Margaret E, Kauffman, Richard D, Herderick, Edward E, Demosky, Stephen J, Evans, Wende, Marcovina, Santica, Santamarina-Fojo, Silvia, Brewer, H Bryan, Hoeg, Jeffrey M

“…ABSTRACTElevated low density lipoprotein cholesterol (LDL-C) and reduced high density lipoprotein cholesterol (HDL-C) concentrations are independent risk…”
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Active serum vitamin D levels are inversely correlated with coronary calcification by WATSON, K. E, ABROLAT, M. L, MALONE, L. L, HOEG, J. M, DOHERTY, T, DETRANO, R, DEMER, L. L

“…Arterial calcification is a common feature of atherosclerosis, occurring in >90% of angiographically significant lesions. Recent evidence from this and other…”
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Altered Compliance and Residual Strain Precede Angiographically Detectable Early Atherosclerosis in Low-Density Lipoprotein Receptor Deficiency by Hong, Mun, Vossoughi, Jafar, Mintz, Gary S, Kauffmann, Richard D, Hoyt, Robert F. Jr, Cornhill, J. Fredrick, Herderick, Edward E, Leon, Martin B, Hoeg, Jeffrey M

“…BACKGROUND This study was performed to detect changes in vascular biomechanical properties early in atherogenesis. METHODS AND RESULTS Age-and weight-matched…”
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Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase by Brousseau, M E, Wang, J, Demosky, Jr, S J, Vaisman, B L, Talley, G D, Santamarina-Fojo, S, Brewer, Jr, H B, Hoeg, J M

“…Familial hypercholesterolemia (FH), a disease caused by a variety of mutations in the low density lipoprotein receptor (LDLr) gene, leads not only to elevated…”
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Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis by Hoeg, J.M. (National Institutes of Health, Bethesda, MD.), Santamarina-Fojo, S, Berard, A.M, Cornhill, J.F, Herderick, E.E, Feldmand, S.H, Haudenschild, C.C, Vaisman, B.L, Hoyt, R.F. Jr, Demosky, S.J. Jr

“…Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits…”
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Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis by Santamarina-Fojo, S, Lambert, G, Hoeg, J M, Brewer, Jr, H B

“…In the past several years significant advances have been made in our understanding of lecithin-cholesterol acyltransferase (LCAT) function. LCAT beneficially…”
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Evaluation of the aortic root by MRI : Insights from patients with homozygous familial hypercholesterolemia by SUMMERS, R. M, ANDRASKO-BOURGEOIS, J, SPRAY, T. L, HOEG, J. M, FEUERSTEIN, I. M, HILL, S. C, JONES, E. C, BUSSE, M. K, WISE, B, BOVE, K. E, RISHFORTH, B. A, TUCKER, E

“…In homozygous familial hypercholesterolemia (HFH), the aortic root is prone to develop atherosclerotic plaque at an early age. However, the aortic wall and…”
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Relation of cholesterol-year score to severity of calcific atherosclerosis and tissue deposition in homozygous familial hypercholesterolemia by Schmidt, Hartmut H.-J., Hill, Suvimol, Makariou, Erini V., Feuerstein, Irwin M., Dugi, Klaus A., Hoeg, Jeffrey M.

“…The high concentrations of low-density lipoprotein cholesterol in plasma lead to accelerated atherosclerosis in patients homozygous for familial…”
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Lecithin:Cholesterol Acyltransferase Overexpression Generates Hyperalpha-lipoproteinemia and a Nonatherogenic Lipoprotein Pattern in Transgenic Rabbits (∗) by Hoeg, Jeffrey M., Vaisman, Boris L., Demosky, Stephen J., Meyn, Susan M., Talley, Glenda D., Hoyt, Robert F., Feldman, Sanford, Bérard, Annie M., Sakai, Nao, Wood, Douglas, Brousseau, Margaret E., Marcovina, Santica, Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…Cholesterol esterification within plasma lipoprotein particles is catalyzed by lecithin:cholesterol acyltransferase (LCAT). The impact of the overexpression of…”
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Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice by Vaisman, Boris L., Klein, Hanns-Georg, Rouis, Mustapha, Bérard, Annie M., Kindt, Marie R., Talley, Glenda D., Meyn, Susan M., Hoyt, Robert F., Marcovina, Santica M., Albers, John J., Hoeg, Jeffrey M., Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…Lecithin cholesterol acyltransferase (LCAT) is a key enzyme which catalyzes the esterification of free cholesterol present in plasma lipoproteins. In order to…”
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Expanding and Understanding Risk Factors for Coronary Heart Disease-Reply by Hoeg, Jeffrey M

“…In Reply.—More than 100 potential risk factors for CHD have been reported. My article focused on 17 promising new risk factors that have therapeutic…”
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Carboxyl-terminal Domain Truncation Alters Apolipoprotein A-I in Vivo Catabolism (∗) by Schmidt, Hartmut H.-J., Remaley, Alan T., Stonik, John A., Ronan, Rosemary, Wellmann, Axel, Thomas, Fairwell, Zech, Loren A., Brewer, H. Bryan, Hoeg, Jeffrey M.

“…Apolipoprotein A-I (apoA-I), the major protein of high density lipoproteins, facilitates reverse cholesterol transport from peripheral tissue to liver. To…”
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Guidelines for Trials of Gene Therapy and Somatic Gene Therapy in Cardiovascular Disease by Hoeg, Jeffrey M

“…The application of new somatic cell therapy and gene therapy products to various diseases, including cardiovascular disease, presents many familiar as well as…”
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Clinical and Laboratory Findings in the Oculocerebrorenal Syndrome of Lowe, with Special Reference to Growth and Renal Function by Charnas, Lawrence R, Bernardini, Isa, Rader, Daniel, Hoeg, Jeffrey M, Gahl, William A

“…THE oculocerebrorenal syndrome of Lowe is an X-linked recessive disorder mapped to Xq24—26 1 , 2 and characterized by congenital cataracts, cognitive…”
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Homozygous familial hypercholesterolemia: A paradigm for phenotypic variation by Hoeg, Jeffrey M.

“…Most, if not all, inborn errors of metabolism manifest phenotypic heterogeneity in their clinical presentation. The term “penetrance” has been used to describe…”
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Distinct Hepatic Receptors for Low Density Lipoprotein and Apolipoprotein E in Humans by Hoeg, Jeffrey M., Demosky, Stephen J., Gregg, Richard E., Schaefer, Ernst J., Brewer, H. Bryan

“…Since the liver is a central organ for lipid and lipoprotein synthesis and catabolism, hepatic receptors for specific apolipoproteins on plasma lipoproteins…”
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Can Genes Prevent Atherosclerosis? by Hoeg, Jeffrey M

“…SELECTED CASEA 59-year-old white woman had a blood cholesterol concentration determined on routine screening. The total plasma cholesterol level was 9.1 mmol/L…”
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Familial Hypercholesterolemia: What the Zebra Can Teach Us About the Horse by Hoeg, Jeffrey M

“…SELECTED CASESCase 1A 6-year-old boy was referred to the National Institutes of Health (NIH) in 1974 for evaluation of xanthomas and hypercholesterolemia…”
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