Search Results - "Hoeffer, Charles A"

mTOR signaling: At the crossroads of plasticity, memory and disease by Hoeffer, Charles A, Klann, Eric

“…Mammalian target of rapamycin (mTOR) is a protein kinase involved in translation control and long-lasting synaptic plasticity. mTOR functions as the central…”
Get full text

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring by Choi, Gloria B., Yim, Yeong S., Wong, Helen, Kim, Sangdoo, Kim, Hyunju, Kim, Sangwon V., Hoeffer, Charles A., Littman, Dan R., Huh, Jun R.

“…Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled…”
Get full text

Dysregulation of mTOR Signaling in Fragile X Syndrome by Sharma, Ali, Hoeffer, Charles A, Takayasu, Yukihiro, Miyawaki, Takahiro, McBride, Sean M, Klann, Eric, Zukin, R. Suzanne

“…Fragile X syndrome, the most common form of inherited mental retardation and leading genetic cause of autism, is caused by transcriptional silencing of the…”
Get full text

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome by Suvrathan, Aparna, Hoeffer, Charles A., Wong, Helen, Klann, Eric, Chattarji, Sumantra, Greenough, William T.

“…Fragile X syndrome (FXS), a common inherited form of mental impairment and autism, is caused by transcriptional silencing of the fragile X mental retardation 1…”
Get full text

Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes by Lemieux, Maddie R, Freigassner, Bernhard, Hanson, Jessica L, Thathey, Zahra, Opp, Mark R, Hoeffer, Charles A, Link, Christopher D

“…Human induced pluripotent stem cells (hiPSCs) derived into neurons offer a powerful in vitro model to study cellular processes. One method to characterize…”
Get full text

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity by Levenga, Josien, Wong, Helen, Milstead, Ryan A, Keller, Bailey N, LaPlante, Lauren E, Hoeffer, Charles A

“…AKT is a kinase regulating numerous cellular processes in the brain, and mutations in are known to affect brain function. AKT is indirectly implicated in…”
Get full text

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease by Ma, Tao, Hoeffer, Charles A, Capetillo-Zarate, Estibaliz, Yu, Fangmin, Wong, Helen, Lin, Michael T, Tampellini, Davide, Klann, Eric, Blitzer, Robert D, Gouras, Gunnar K

“…The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological…”
Get full text

Testing associations between human anxiety and genes previously implicated by mouse anxiety models by Brasher, Maizy S., Mize, Travis J., Thomas, Aimee L., Hoeffer, Charles A., Ehringer, Marissa A., Evans, Luke M.

“…Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic…”
Get full text

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits by Evans, Luke M, Arehart, Christopher H, Grotzinger, Andrew D, Mize, Travis J, Brasher, Maizy S, Stitzel, Jerry A, Ehringer, Marissa A, Hoeffer, Charles A

“…It remains unknown to what extent gene-gene interactions contribute to complex traits. Here, we introduce a new approach using predicted gene expression to…”
Get full text

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior by Hoeffer, Charles A., Tang, Wei, Wong, Helen, Santillan, Arturo, Patterson, Richard J., Martinez, Luis A., Tejada-Simon, Maria V., Paylor, Richard, Hamilton, Susan L., Klann, Eric

“…FK506-binding protein 12 (FKBP12) binds the immunosuppressant drugs FK506 and rapamycin and regulates several signaling pathways, including mammalian target of…”
Get full text

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice by Antion, Marcia D., Hou, Lingfei, Wong, Helen, Hoeffer, Charles A., Klann, Eric

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation by Hoeffer, Charles A, Cowansage, Kiriana K, Arnold, Elizabeth C, Banko, Jessica L, Moerke, Nathan J, Rodriguez, Ricard, Schmidt, Enrico K, Klosi, Edvin, Chorev, Michael, Lloyd, Richard E, Pierre, Philippe, Wagner, Gerhard, LeDoux, Joseph E, Klann, Eric

“…Considerable evidence indicates that the general blockade of protein synthesis prevents both the initial consolidation and the postretrieval reconsolidation of…”
Get full text

Synaptic Plasticity Deficits and Mild Memory Impairments in Mouse Models of Chronic Granulomatous Disease by Kishida, Kenneth T., Hoeffer, Charles A., Hu, Daoying, Pao, Maryland, Holland, Steven M., Klann, Eric

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments by Levenga, Josien, Krishnamurthy, Pavan, Rajamohamedsait, Hameetha, Wong, Helen, Franke, Thomas F, Cain, Peter, Sigurdsson, Einar M, Hoeffer, Charles A

“…Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological…”
Get full text

RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging by Wong, Helen, Buck, Jordan M, Borski, Curtis, Pafford, Jessica T, Keller, Bailey N, Milstead, Ryan A, Hanson, Jessica L, Stitzel, Jerry A, Hoeffer, Charles A

“…Regulator of calcineurin 1 (RCAN1) is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer's disease (AD) and normal aging. AD…”
Get full text

The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling by Hoeffer, Charles A, Dey, Asim, Sachan, Nita, Wong, Helen, Patterson, Richard J, Shelton, John M, Richardson, James A, Klann, Eric, Rothermel, Beverly A

“…Regulator of calcineurin 1 (RCAN1/MCIP1/DSCR1) regulates the calmodulin-dependent phosphatase calcineurin. Because it is located on human chromosome 21, RCAN1…”
Get full text

Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment by Hoeffer, Charles A, Wong, Helen, Cain, Peter, Levenga, Josien, Cowansage, Kiriana K, Choi, Yoon, Davy, Camille, Majmundar, Neil, McMillan, D Randy, Rothermel, Beverly A, Klann, Eric

“…Regulator of calcineurin 1 (RCAN1) controls the activity of calcium/calmodulin-dependent phosphatase calcineurin (CaN), which has been implicated in human…”
Get full text

cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits by Wincott, Charlotte M., Abera, Sinedu, Vunck, Sarah A., Tirko, Natasha, Choi, Yoon, Titcombe, Roseann F., Antoine, Shannon O., Tukey, David S., DeVito, Loren M., Hofmann, Franz, Hoeffer, Charles A., Ziff, Edward B.

“…•cGKII KO are significantly deficient in working memory in the Radial Arm Maze.•cGKII KO show decreased repetitive behavior in Marble Burying.•cGKII KO exhibit…”
Get full text

AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila by Ramaswami, Mani, Sanyal, Subhabrata, Sandstrom, David J, Hoeffer, Charles A

“…Activity-regulated gene expression mediates many aspects of neural plasticity, including long-term memory. In the prevailing view, patterned synaptic activity…”
Get full text

TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord by Milstead, Ryan A, Link, Christopher D, Xu, Zuoshang, Hoeffer, Charles A

“…Abstract Transactive response DNA binding protein 43 kilodaltons (TDP-43) is a DNA and RNA binding protein associated with severe neurodegenerative diseases…”
Get full text