Search Results - "Hoe, Nicholas"

A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation by Wang, YongQiang, Liao, Mingxiang, Hoe, Nicholas, Acharya, Poulomi, Deng, Changhui, Krutchinsky, Andrew N., Correia, Maria Almira

“…Cytochromes P450 (P450s) incur phosphorylation. Although the precise role of this post-translational modification is unclear, marking P450s for degradation is…”
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Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes by Curtis, Christina, Landis, Gary N, Folk, Donna, Wehr, Nancy B, Hoe, Nicholas, Waskar, Morris, Abdueva, Diana, Skvortsov, Dmitriy, Ford, Daniel, Luu, Allan, Badrinath, Ananth, Levine, Rodney L, Bradley, Timothy J, Tavaré, Simon, Tower, John

“…Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription…”
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CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases by Pabarcus, Michael K., Hoe, Nicholas, Sadeghi, Sheila, Patterson, Cam, Wiertz, Emmanuel, Correia, Maria Almira

“…Human liver CYP3A4 is an endoplasmic reticulum (ER)-anchored hemoprotein responsible for the metabolism of >50% of clinically prescribed drugs. After…”
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A novel proteomics-based clinical diagnostics technology identifies heterogeneity in activated signaling pathways in gastric cancers by Lee, Jeeyun, Kim, Sung, Kim, Phillip, Liu, Xinjun, Lee, Tani, Kim, Kyoung-Mee, Do, In-Gu, Park, Joon Oh, Park, Se Hoon, Jang, Jiryeon, Hoe, Nicholas, Harvie, Gulia, Kuller, Anne, Jain, Anjali, Meyer, Gary, Leesman, Glen, Park, Young Suk, Choi, Min Gew, Sohn, Tae Sung, Bae, Jae Moon, Lim, Ho Yeong, Singh, Sharat, Kang, Won Ki

“…The aim of this study was to utilize the proteomics-based Collaborative Enzyme Enhanced Reactive (CEER) immunoassay to investigate protein tyrosine…”
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Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster by Grover, Dhruv, Ford, Daniel, Brown, Christopher, Hoe, Nicholas, Erdem, Aysen, Tavaré, Simon, Tower, John

“…Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The…”
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Assessing the impact of temperature, pH, light and chemical oxidation on fucoxanthin colour changes, antioxidant activity and the resulting metabolites by Yusof, Zuhaili, Lim, Vuanghao, Khong, Nicholas Mun Hoe, Choo, Wee Sim, Foo, Su Chern

“…BACKGROUND The present study evaluated the effects of temperature, pH, light and chemical oxidation on fucoxanthin changes in terms of colour, antioxidant…”
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Efficient solvent extraction of antioxidant-rich extract from a tropical diatom, Chaetoceros calcitrans (Paulsen) Takano 1968 by Foo, Su Chern, Yusoff, Fatimah Md, Ismail, Maznah, Basri, Mahiran, Khong, Nicholas Mun Hoe, Chan, Kim Wei, Yau, Sook Kun

“…To compare the in vitro antioxidant capacity of a diatom, Chaetoceros calcitrans (C. calcitrans) extracted using six types of solvents. Each extract was…”
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Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster by Hoe, Nicholas, Huang, Chung M., Landis, Gary, Verhage, Marian, Ford, Daniel, Yang, Junsheng, van Leeuwen, Fred W., Tower, John

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Abstract 1469: Integrated analysis of microRNA, mRNA, and protein expression utilizing MultiOmyxTM and NanoStringTM from formalin-fixed paraffin-embedded, lung, head and neck, breast, and melanoma tumors by Au, Qingyan, Padmanabhan, RaghavKrishna, Tran, Nam, Chandramohan, Lakshmi, Hoe, Nicholas

“…Abstract Cancer is characterized as a loss of normal cellular regulation, due to accumulation of mutations and disruption of complex biological pathways…”
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Abstract 2092: Tumor-infiltrating myeloid cells: Using MultiOmyx to distinguish between TAMs, TANs, and MDSCs in the pancreatic tumor microenvironment by Juncker-Jensen, Anna, Hoe, Nicholas, Kuo, Judy, Au, Qingyan, Zhu, Shijun, Leones, Eric, Sahafi, Flora

“…Abstract Myeloid cells are the primary recruited effector cells during inflammation. A subset of these, consisting primarily of tumor-associated M1/M2…”
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Characterization of Immunosuppressive Cells Using MultiOmyx in Hematological Malignancies by Au, Qingyan, Hanafi, Arezoo, Parnell, Erinn, Kuo, Judy, Leones, Eric, Sahafi, Flora, Padmanabhan, Raghavkrishna, Hoe, Nicholas, William, Josette

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MO3-13-6 [Encore]Characterization of Immunosuppressive Cells Using MultiOmyx in Hematological Malignancies by Au, Qingyan, Hanafi, Arezoo, Parnell, Erinn, Kuo, Judy, Leones, Eric, Sahafi, Flora, Padmanabhan, Raghavkrishna, Hoe, Nicholas, William, Josette

“…Abstract Background Tumor associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC) can assist tumors to escape immune surveillance within the…”
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Abstract 497: Characterization of TIGIT expression using MultiOmyxTM hyperplexed immunofluorescence assay in solid tumors by Au, Qingyan, Hanifi, Arezoo, Parnell, Erinn, Kuo, Judy, Leones, Eric, Sahafi, Flora, Pham, Kathy, Padmanabhan, RaghavKrishna, Hoe, Nicholas, William, Josette

“…Abstract TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a recently identified immune-receptor that is expressed on T cells, natural killer (NK)…”
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Using a multiplexed immunofluorescence approach to compare immune cell populations in subtypes of non-small cell lung cancer by Juncker-Jensen, Anna, Reddy, Vivek, Parnell, Erinn, Nagy, Mate Levente, Kuo, Judy, Leones, Eric, Sahafi, Flora, Hoe, Nicholas, William, Josette

“…Abstract only e20702 Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all lung cancer cases, and is characterized by a poor…”
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Quantitative image profiling of the tumor microenvironment on double stained immunohistochemistry images using deep learning by Nagy, Mate Levente, Juncker-Jensen, Anna, Ovadia, Ben, Smale, Robert, Yamamoto, Karen, William, Josette, Hoe, Nicholas, Padmanabhan, Raghav

“…Abstract only e14619 Background: Spatial locations of immune cells in the tumor microenvironment (TME) correlate with clinical outcome in cancers. A worse…”
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Characterization of Myeloid-Derived Suppressor Cells and Tumor Associated Macrophages Using MultiOmyxTM Hyperplexed Immunofluorescence Assay in Hodgkin Lymphoma by Au, Qingyan, Fang, Jun, Juncker-Jensen, Anna, Kuo, Judy, Leones, Eric, Sahafi, Flora, Padmanabhan, RaghavKrishna, Hoe, Nicholas, William, Josette

“…Tumor microenvironment (TME) consists of heterogeneous subsets of myeloid cells and plays a crucial role in promoting cancer development and metastasis. Tumor…”
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Abstract 2256: Efficient large-scale cell classification and analysis for MultiOmyxTMassays: A deep learning approach by Nagy, Mate L., Hanifi, Arezoo, Tirupsur, Ahalya, Wong, Geoffrey, Fang, Jun, Hoe, Nicholas, Au, Qingyan, Padmanabhan, Raghav K.

“…Abstract Traditional immunohistochemistry (IHC) techniques utilize one slide per biomarker. When clinical samples are precious and the number of serial…”
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Abstract 5135: Detection of IFNγ induced PDL1 expression by combined in situ RNA analysis and protein profiling from a single FFPE slide by Au, Qingyan, Nguyen, Kathy, Lazare, Michael S., Moler, Edward J., Hoe, Nicholas

“…Abstract PD1 ligands (PDL1) are often upregulated on the cell surface of many different tumors. The primary role of PDL1 in cancer is to inhibit T-cell…”
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Abstract 5135: Detection of IFN induced PDL1 expression by combined in situ RNA analysis and protein profiling from a single FFPE slide by Au, Qingyan, Nguyen, Kathy, Lazare, Michael S, Moler, Edward J, Hoe, Nicholas

“…PD1 ligands (PDL1) are often upregulated on the cell surface of many different tumors. The primary role of PDL1 in cancer is to inhibit T-cell mediated immune…”
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Abstract 4146: MultiOmyx multiplexed tumor infiltrating lymphocyte panel provides comprehensive immunophenotyping from a single FFPE slide by Au, Qingyan, Nguyen, Kathy, Padmanabhan, Raghav, Kuller, Anne, Moler, Eddie, Hoe, Nicholas

“…Abstract Immune checkpoint therapies target immune regulatory pathways to enhance anti-tumor immune response. These therapies have contributed to important…”
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