Search Results - "Hodny, Z."

Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells by Kyjacova, L, Hubackova, S, Krejcikova, K, Strauss, R, Hanzlikova, H, Dzijak, R, Imrichova, T, Simova, J, Reinis, M, Bartek, J, Hodny, Z

“…Fractionated ionizing radiation combined with surgery or hormone therapy represents the first-choice treatment for medium to high-risk localized prostate…”
Get full text

IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2 by Hubackova, S, Kucerova, A, Michlits, G, Kyjacova, L, Reinis, M, Korolov, O, Bartek, J, Hodny, Z

“…Cellular senescence provides a biological barrier against tumor progression, often associated with oncogene-induced replication and/or oxidative stress,…”
Get full text

Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation by Stetka, J., Vyhlidalova, P., Lanikova, L., Koralkova, P., Gursky, J., Hlusi, A., Flodr, P., Hubackova, S., Bartek, J., Hodny, Z., Divoky, V.

“…Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders…”
Get full text

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1 by Moudry, P, Lukas, C, Macurek, L, Neumann, B, Heriche, J-K, Pepperkok, R, Ellenberg, J, Hodny, Z, Lukas, J, Bartek, J

“…53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling…”
Get full text

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis by Evangelou, K, Bartkova, J, Kotsinas, A, Pateras, I S, Liontos, M, Velimezi, G, Kosar, M, Liloglou, T, Trougakos, I P, Dyrskjot, L, Andersen, C L, Papaioannou, M, Drosos, Y, Papafotiou, G, Hodny, Z, Sosa-Pineda, B, Wu, X-R, Klinakis, A, Ørntoft, T, Lukas, J, Bartek, J, Gorgoulis, V G

“…Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the…”
Get full text

Cytokine expression and signaling in drug-induced cellular senescence by Novakova, Z, Hubackova, S, Kosar, M, Janderova-Rossmeislova, L, Dobrovolna, J, Vasicova, P, Vancurova, M, Horejsi, Z, Hozak, P, Bartek, J, Hodny, Z

“…Cellular senescence guards against cancer and modulates aging; however, the underlying mechanisms remain poorly understood. Here, we show that genotoxic drugs…”
Get full text

The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods by Salajkova, Sarka, Havel, Filip, Sramek, Michal, Novotny, Filip, Malinak, David, Dolezal, Rafael, Prchal, Lukas, Benkova, Marketa, Soukup, Ondrej, Musilek, Kamil, Kuca, Kamil, Bartek, Jiri, Proska, Jan, Zarska, Monika, Hodny, Zdenek

“…Plasmonic photothermal cancer therapy by gold nanorods (GNRs) emerges as a promising tool for cancer treatment. The goal of this study was to design cationic…”
Get full text

Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution by Kopecky, J. (Academy of Sciences of the Czech Republic, Prague, Czech Republic.), Hodny, Z, Rossmeisl, M, Syrovy, I, Kozak, L.P

“…We seek to determine whether increased energy dissipation in adipose tissue can prevent obesity. Transgenic mice with C57BL6/J background and the adipocyte…”
Get full text

Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology by Kopecký, J, Rossmeisl, M, Hodný, Z, Syrový, I, Horáková, M, Kolárová, P

“…C57BL6/J mice with the expression of the mitochondrial uncoupling protein (UCP) gene from the fat-specific aP2 gene promoter were used to study the mechanism…”
Get full text

Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours by Bartkova, J., Moudry, P., Hodny, Z., Lukas, J., Rajpert-De Meyts, E., Bartek, J.

“…Summary Heterochromatinization has been implicated in fundamental biological and pathological processes including differentiation, senescence, ageing and…”
Get full text

Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice by Stefl, B, Janovska, A, Hodny, Z, Rossmeisl, M, Horakova, M, Syrovy, I, Bemova, J, Bendlova, B, Kopecky, J

“…The role of brown adipose tissue in total energy balance and cold-induced thermogenesis was studied. Mice expressing mitochondrial uncoupling protein 1 (UCP-1)…”
Get full text

High expression of uncoupling protein 2 in foetal liver by Hodný, Zdeněk, Kolářová, Petra, Rossmeisl, Martin, Horáková, Milada, Nibbelink, Maryse, Penicaud, Luc, Casteilla, Louis, Kopecký, Jan

“…To assess the putative role of mitochondrial uncoupling protein 2 (UCP2) during perinatal development, its expression was analysed in mice and rats. Expression…”
Get full text

NQO1 2 Polymorphism Predicts Overall Survival in Primary MDS Patients by Moudra, A, Minarik, L, Vančurová, M, Hodný, Z, Bartek, J, Jonášová, A

Get full text

272 NQO12 POLYMORPHISM DOES NOT PREDICT OVERALL SURVIVAL IN HIGHER RISK MDS PATIENTS TREATED WITH 5-AZACYTIDINE by Moudra, A, Vancurová, M, Machalová, V, Hodný, Z, Bartek, J, Jonáŝová, A

Get full text

Photothermal induction of pyroptosis in malignant glioma spheroids using (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods by Zarska, Monika, Novak, Ondrej, Jakubcova, Tereza, Novotny, Filip, Urbancokova, Alexandra, Havel, Filip, Novak, Josef, Raabova, Helena, Musilek, Kamil, Filimonenko, Vlada, Bartek, Jiri, Proska, Jan, Hodny, Zdenek

“…Plasmonic photothermal therapy (PPTT) employing plasmonic gold nanorods (GNRs) presents a potent strategy for eradication of tumors including aggressive brain…”
Get full text

In vivo mapping of the human adenine nucleotide translocator-2 (ANT2) promoter provides support for regulation by a pair of proximal Sp1-activating sites and an upstream silencer element by Luciakova, K, Hodny, Z, Barath, P, Nelson, B D

“…Regulatory factors bound to the human adenine nucleotide translocator-2 (ANT2) promoter have been mapped in HeLa cells by in vivo DNase I protection and…”
Get full text

Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis by Flegr, J, Hrusková, M, Hodný, Z, Novotná, M, Hanusová, J

“…Between 20% and 60% of the population of most countries are infected with the protozoan Toxoplasma gondii. Subjects with clinically asymptomatic life-long…”
Get more information

Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment by Hornofova, Terezie, Pokorna, Barbora, Hubackova, Sona Stemberkova, Uvizl, Alena, Kosla, Jan, Bartek, Jiri, Hodny, Zdenek, Vasicova, Pavla

“…Repetitive sequences are among the most unstable regions in the eukaryotic genome and defects in their maintenance correlate with premature aging and cancer…”
Get full text

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair by Vancurova, Marketa, Hanzlikova, Hana, Knoblochova, Lucie, Kosla, Jan, Majera, Dusana, Mistrik, Martin, Burdova, Kamila, Hodny, Zdenek, Bartek, Jiri

“…•Super-resolution microscopy finds PML juxtaposed to persistent radiation induced foci.•Recruitment of PML to DNA damage sites depends on the RNF168-53BP1…”
Get full text

The human nucleoporin Tpr protects cells from RNA-mediated replication stress by Kosar, Martin, Giannattasio, Michele, Piccini, Daniele, Maya-Mendoza, Apolinar, García-Benítez, Francisco, Bartkova, Jirina, Barroso, Sonia I., Gaillard, Hélène, Martini, Emanuele, Restuccia, Umberto, Ramirez-Otero, Miguel Angel, Garre, Massimiliano, Verga, Eleonora, Andújar-Sánchez, Miguel, Maynard, Scott, Hodny, Zdenek, Costanzo, Vincenzo, Kumar, Amit, Bachi, Angela, Aguilera, Andrés, Bartek, Jiri, Foiani, Marco

“…Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates…”
Get full text