Search Results - "Hodivala‐Dilke, Kairbaan M"

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread by Wong, Ping-Pui, Demircioglu, Fevzi, Ghazaly, Essam, Alrawashdeh, Wasfi, Stratford, Michael R.L., Scudamore, Cheryl L., Cereser, Biancastella, Crnogorac-Jurcevic, Tatjana, McDonald, Stuart, Elia, George, Hagemann, Thorsten, Kocher, Hemant M., Hodivala-Dilke, Kairbaan M.

“…Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side effects, is a primary goal of cancer research. In mouse and human…”
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Effects of senescence on the tumour microenvironment and response to therapy by Reynolds, Louise E., Maallin, Seynab, Haston, Scott, Martinez‐Barbera, Juan Pedro, Hodivala‐Dilke, Kairbaan M., Pedrosa, Ana‐Rita

“…Cellular senescence is a state of durable cell arrest that has been identified both in vitro and in vivo. It is associated with profound changes in gene…”
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Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth by Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.

“…The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour…”
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Endothelial FAK is required for tumour angiogenesis by Tavora, Bernardo, Batista, Silvia, Reynolds, Louise E., Jadeja, Shalini, Robinson, Stephen, Kostourou, Vassiliki, Hart, Ian, Fruttiger, Marcus, Parsons, Maddy, Hodivala‐Dilke, Kairbaan M.

“…Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a fundamental role in integrin and growth factor mediated signalling and is an…”
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“Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP by D'Amico, Gabriela, Muñoz‐Félix, José M, Pedrosa, Ana Rita, Hodivala‐Dilke, Kairbaan M

“…Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine , Esteban and…”
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Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment by Wong, Ping-Pui, Bodrug, Natalia, Hodivala-Dilke, Kairbaan M.

“…Several studies have explored the potential of targeting tumor angiogenesis in cancer treatment. Anti-angiogenesis monotherapy, which reduces blood vessel…”
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Endothelial FAK is required for tumour angiogenesis by Tavora, Bernardo, Batista, Silvia, Reynolds, Louise E, Jadeja, Shalini, Robinson, Stephen, Kostourou, Vassiliki, Hart, Ian, Fruttiger, Marcus, Parsons, Maddy, Hodivala‐Dilke, Kairbaan M

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A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia by Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V

“…The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors…”
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Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy by Tavora, Bernardo, Reynolds, Louise E., Batista, Silvia, Demircioglu, Fevzi, Fernandez, Isabelle, Lechertier, Tanguy, Lees, Delphine M., Wong, Ping-Pui, Alexopoulou, Annika, Elia, George, Clear, Andrew, Ledoux, Adeline, Hunter, Jill, Perkins, Neil, Gribben, John G., Hodivala-Dilke, Kairbaan M.

“…The tumour microenvironment can influence its response to anticancer therapies; here, the enzyme FAK in endothelial cells is shown to have a role in the…”
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Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861 by Pedrosa, Ana-Rita, Bodrug, Natalia, Gomez-Escudero, Jesus, Carter, Edward P, Reynolds, Louise E, Georgiou, Paraskivi Natalia, Fernandez, Isabelle, Lees, Delphine M, Kostourou, Vassiliki, Alexopoulou, Annika N, Batista, Silvia, Tavora, Bernardo, Serrels, Bryan, Parsons, Maddy, Iskratsch, Thomas, Hodivala-Dilke, Kairbaan M

“…Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861…”
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The role of β3-integrins in tumor angiogenesis: context is everything by Robinson, Stephen D, Hodivala-Dilke, Kairbaan M

“…Highlights ► αvβ3-Integrin antagonists function differently depending on the matrix to which cells are bound. ► The achieved dose of αvβ3-integrin antagonist…”
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Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression by Lees, Delphine M., Reynolds, Louise E., Pedrosa, Ana Rita, Roy-Luzarraga, Marina, Hodivala-Dilke, Kairbaan M.

“…Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed in many cancer types and in vivo studies have shown that vascular…”
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Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors by Silva, Rita G, Da Violante, Georges, Reynolds, Andrew R, Jones, Matt C, Robinson, Stephen D, Perron-Sierra, Françoise, Tucker, Gordon C, Gourlaouen, Morgane, Hart, Ian R, Jones, Dylan T, Hodivala-Dilke, Kairbaan M, Norman, Jim C, Watson, Alan R, Saunders, Garry, Kostourou, Vassiliki, Welti, Jonathan C, Salih, Mishal

“…Inhibitors of α v β 3 and α v β 5 integrins have previously been shown to inhibit tumor angiogenesis and growth and have entered human clinical trials. Andrew…”
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Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth by Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.

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Dual role of pericyte α6β1-integrin in tumour blood vessels by Reynolds, Louise E, D'Amico, Gabriela, Lechertier, Tanguy, Papachristodoulou, Alexandros, Muñoz-Félix, José M, De Arcangelis, Adèle, Baker, Marianne, Serrels, Bryan, Hodivala-Dilke, Kairbaan M

“…The α6β1-integrin is a major laminin receptor, and formation of a laminin-rich basement membrane is a key feature in tumour blood vessel stabilisation and…”
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Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression by Lees, Delphine M., Reynolds, Louise E., Pedrosa, Ana Rita, Roy-Luzarraga, Marina, Hodivala-Dilke, Kairbaan M.

“…A correction to this paper has been published: https://doi.org/10.1007/s10456-021-09802-9…”
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Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins by Reynolds, Louise E, Wyder, Lorenza, Lively, Julie C, Taverna, Daniela, Robinson, Stephen D, Huang, Xiaozhu, Sheppard, Dean, Hynes, Richard O, Hodivala-Dilke, Kairbaan M

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Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice by Steri, Veronica, Ellison, Tim S, Gontarczyk, Aleksander Maksym, Weilbaecher, Katherine, Schneider, Jochen G, Edwards, Dylan, Fruttiger, Marcus, Hodivala-Dilke, Kairbaan M, Robinson, Stephen Douglas

“…RATIONALE:The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during tumor growth has long suggested that the endothelial expression of…”
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Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen‐1 and nidogen‐2 by Martino‐Echarri, Estefanía, Fernández‐Rodríguez, Rubén, Rodríguez‐Baena, Francisco Javier, Barrientos‐Durán, Antonio, Torres‐Collado, Antoni X., Carmen Plaza‐Calonge, María, Amador‐Cubero, Suyapa, Cortés, Javier, Reynolds, Louise E., Hodivala‐Dilke, Kairbaan M., Rodríguez‐Manzaneque, Juan Carlos

“…The extracellular protease ADAMTS1 (A disintegrin and metalloprotease with thrombospondin repeats 1) has been described as an anti‐angiogenic molecule and its…”
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Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth by LAMAGNA, Chrystelle, HODIVALA-DILKE, Kairbaan M, IMHOF, Beat A, AURRAND-LIONS, Michel

“…The junctional adhesion molecule-C (JAM-C) was recently described as an adhesion molecule localized at interendothelial contacts and involved in leukocyte…”
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