Search Results - "Hodgson, Clague P."

Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system by Luke, Jeremy, Carnes, Aaron E, Hodgson, Clague P, Williams, James A

“…Abstract To ensure safety, regulatory agencies recommend elimination of antibiotic resistance markers from therapeutic and vaccine plasmid DNA vectors. Here,…”
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Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine by LUKE, Jeremy M, SIMON, Gregory G, SÖDERHOLM, Jonas, ERRETT, John S, AUGUST, J. Thomas, GALE, Michael, HODGSON, Clague P, WILLIAMS, James A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inducible Escherichia coli fermentation for increased plasmid DNA production by Carnes, Aaron E., Hodgson, Clague P., Williams, James A.

“…Bacterial plasmids are the vectors of choice for DNA vaccines and short‐term gene therapeutics. Growing plasmid DNA by microbial (Escherichia coli)…”
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Thermostable tag (TST) protein expression system: Engineering thermotolerant recombinant proteins and vaccines by Luke, Jeremy M., Carnes, Aaron E., Sun, Ping, Hodgson, Clague P., Waugh, David S., Williams, James A.

“…Methods to increase temperature stability of vaccines and adjuvants are needed to reduce dependence on cold chain storage. We report herein creation and…”
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Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production by Williams, James A., Carnes, Aaron E., Hodgson, Clague P.

“…Critical molecular and cellular biological factors impacting design of licensable DNA vaccine vectors that combine high yield and integrity during bacterial…”
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Generic plasmid DNA production platform incorporating low metabolic burden seed-stock and fed-batch fermentation processes by Williams, James A, Luke, Jeremy, Langtry, Sarah, Anderson, Sheryl, Hodgson, Clague P, Carnes, Aaron E

“…DNA vaccines have tremendous potential for rapid deployment in pandemic applications, wherein a new antigen is "plugged" into a validated vector, and rapidly…”
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Virosomes: Cationic Liposomes Enhance Retroviral Transduction by Hodgson, Clague P, Solaiman, Fauzia

“…Retrovirus-derived vectors are overwhelmingly preferred over other methods for ex vivo gene therapy because they provide permanent integration of foreign genes…”
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Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression by Carnes, Aaron E, Luke, Jeremy M, Vincent, Justin M, Schukar, Angela, Anderson, Sheryl, Hodgson, Clague P, Williams, James A

“…Industrial plasmid DNA manufacturing processes are needed to meet the quality, economy, and scale requirements projected for future commercial products. We…”
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A Noncytolytic α Toxin Recombinant Protein Protects Turkeys Against Clostridium septicum Challenge by Lancto, Cheryl A, Foster, Linda K, Kromm, Michelle M, McComb, Brian, Williams, James, Luke, Jeremy, Carnes, Aaron, Hodgson, Clague P, Foster, Douglas N

“…Clostridium septicum and its associated cytolytic α toxin, along with several other clostridial species, has been implicated as the causative agent of…”
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Plasmid DNA production combining antibiotic-free selection, inducible high yield fermentation, and novel autolytic purification by Carnes, Aaron E, Hodgson, Clague P, Luke, Jeremy M, Vincent, Justin M, Williams, James A

“…DNA vaccines and gene medicines, derived from bacterial plasmids, are emerging as an important new class of pharmaceuticals. However, the challenges of…”
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Critical design criteria for minimal antibiotic-free plasmid vectors necessary to combine robust RNA Pol II and Pol III-mediated eukaryotic expression with high bacterial production yields by Carnes, Aaron E., Luke, Jeremy M., Vincent, Justin M., Anderson, Sheryl, Schukar, Angela, Hodgson, Clague P., Williams, James A.

“…Background For safety considerations, regulatory agencies recommend the elimination of antibiotic resistance markers and non‐essential sequences from plasmid…”
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Vector Insert-Targeted Integrative Antisense Expression System for Plasmid Stabilization by Luke, Jeremy M, Carnes, Aaron E, Hodgson, Clague P, Williams, James A

“…Some DNA vaccine and gene therapy vector-encoded transgenes are toxic to the E. coli plasmid production host resulting in poor production yields. For plasmid…”
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532. An Inducible Fed-Batch Fermentation Process for Scale-Up and Production of DNA Vaccines and Gene Medicines by Carnes, Aaron E., Williams, James A., Hodgson, Clague P.

“…It is essential to devise industrial processes whereby plasmid DNA can be manufactured to meet the quality, economy, and scale requirements projected for…”
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The Vector Void in Gene Therapy by Hodgson, Clague P

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Modular retro-vectors for transgenic and therapeutic use by Solaiman, Fauzia, Zink, Mary Ann, Xu, Guoping, Grunkemeyer, James, Cosgrove, Dominic, Saenz, Jennifer, Hodgson, Clague P.

“…Retroviruses have been used for many years as vectors for human gene therapy as well as for making transgenic animals. However, the efficient insertion of…”
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Conserved, Erythropoietin-Responsive VL30 Promoters Isolated from Erythroid Progenitor Cells by Staplin, William R, Hodgson, Clague P, Knezetic, Joseph A

“…ABSTRACT Virus-like 30S (VL30) elements are endogenous retro-elements of the mouse retrotransposon family. These elements are transcriptionally responsive in a…”
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Fusogenic effects of murine retroviruses and cationic enhancers of transduction by Xu, G, Solaiman, F, Zink, M A, Hodgson, C P

“…The maturation of retrovirus particles involves proteolytic cleavage of the envelope glycoprotein transmembrane component, resulting in conversion of the virus…”
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A Noncytolytic α Toxin Recombinant Protein Protects Turkeys AgainstClostridium septicumChallenge by Lancto, Cheryl A., Foster, Linda K., Kromm, Michelle M., McComb, Brian, Williams, James, Luke, Jeremy, Carnes, Aaron, Hodgson, Clague P., Foster, Douglas N.

“…Clostridium septicumand its associated cytolytic α toxin, along with several other clostridial species, has been implicated as the causative agent of…”
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Casein, actin, and tubulin expression during early involution in bovine and murine mammary tissue by Wiens, D J, Brooks, C L, Hodgson, C P

“…Hybridization methods and in vitro translation were used to examine the expression and functional condition of messenger RNA encoding caseins and cytoskeletal…”
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Retrotransposon Gene Engineering by Cook, R. Frank, Cook, Sheila J, Hodgson, Clague P

“…We have used a mobile mouse VL30 genetic element together with retroviral helper cells to efficiently transmit and express chimeric foreign gene sequences in…”
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