Search Results - "Hodgkinson, L."

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer by Hodgkinson, Cassandra L, Morrow, Christopher J, Li, Yaoyong, Metcalf, Robert L, Rothwell, Dominic G, Trapani, Francesca, Polanski, Radoslaw, Burt, Deborah J, Simpson, Kathryn L, Morris, Karen, Pepper, Stuart D, Nonaka, Daisuke, Greystoke, Alastair, Kelly, Paul, Bola, Becky, Krebs, Matthew G, Antonello, Jenny, Ayub, Mahmood, Faulkner, Suzanne, Priest, Lynsey, Carter, Louise, Tate, Catriona, Miller, Crispin J, Blackhall, Fiona, Brady, Ged, Dive, Caroline

“…Circulating tumor cells from patients with small-cell lung cancer can form tumors in mice, and their derived explants recapitulate the patients' response to…”
Get full text

Deep roots and soil structure by Gao, W., Hodgkinson, L., Jin, K., Watts, C.W., Ashton, R.W., Shen, J., Ren, T., Dodd, I.C., Binley, A., Phillips, A.L., Hedden, P., Hawkesford, M. J., Whalley, W.R.

“…In this opinion article we examine the relationship between penetrometer resistance and soil depth in the field. Assuming that root growth is inhibited at…”
Get full text

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer by POLANSKI, Radostaw, HODGKINSON, Cassandra L, SMITH, Paul D, BLACKHALL, Fiona, DIVE, Caroline, MORROW, Christopher J, FUSI, Alberto, NONAKA, Daisuke, PRIEST, Lynsey, KELLY, Paul, TRAPANI, Francesca, BISHOP, Paul W, WHITE, Anne, CRITCHLOW, Susan E

“…The monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase I evaluation in the United Kingdom. AZD3965 is proposed, via lactate transport…”
Get full text

Root growth in field-grown winter wheat: Some effects of soil conditions, season and genotype by Hodgkinson, L., Dodd, I.C., Binley, A., Ashton, R.W., White, R.P., Watts, C.W., Whalley, W.R.

“…•We present evidence to support the hypothesis that the general and well-documented shape of the relationship between root length density and soil depth in UK…”
Get full text

X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron by Hodgkinson, Victoria L, Dale, Jeffery M, Garcia, Michael L, Weisman, Gary A, Lee, Jaekwon, Gitlin, Jonathan D, Petris, Michael J

“…ATP7A is a copper‐transporting P‐type ATPase that is essential for cellular copper homeostasis. Loss‐of‐function mutations in the ATP7A gene result in Menkes…”
Get full text

What's the point of the type III secretion system needle? by Blocker, Ariel J, Deane, Janet E, Veenendaal, Andreas K.J, Roversi, Pietro, Hodgkinson, Julie L, Johnson, Steven, Lea, Susan M

“…Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the…”
Get full text

type III secretion system needle tip complex mediates host cell sensing and translocon insertion by Veenendaal, Andreas K.J, Hodgkinson, Julie L, Schwarzer, Lynn, Stabat, David, Zenk, Sebastian F, Blocker, Ariel J

“…Type III secretion systems (T3SSs) are essential virulence determinants of many Gram-negative bacterial pathogens. The Shigella T3SS consists of a cytoplasmic…”
Get full text

Crossing the Line: The Law of War and Cyber Engagement – Applying the Existing Body of Law to this New National Security Threat by Hodgkinson, Sandra L.

“…[...]the article will address the applicability of other laws. [...]there is sufficiently broad-based international consensus that cyber-attacks can be…”
Get full text

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders by Fieten, Hille, Gill, Yadvinder, Martin, Alan J, Concilli, Mafalda, Dirksen, Karen, van Steenbeek, Frank G, Spee, Bart, van den Ingh, Ted S G A M, Martens, Ellen C C P, Festa, Paola, Chesi, Giancarlo, van de Sluis, Bart, Houwen, Roderick H J H, Watson, Adrian L, Aulchenko, Yurii S, Hodgkinson, Victoria L, Zhu, Sha, Petris, Michael J, Polishchuk, Roman S, Leegwater, Peter A J, Rothuizen, Jan

“…The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper…”
Get full text

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout by Stabat, David, Blocker, Ariel J, da Fonseca, Paula C A, Hodgkinson, Julie L, Horsley, Ashley, Simon, Martha, Wall, Joseph S, Johnson, Steven, Lea, Susan M, Morris, Edward P

“…Gram-negative bacteria use type III secretion systems (T3SSs) to pass virulence factors into host cells, making them potential therapeutic targets to combat…”
Get full text

Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network by Zhu, Sha, Shanbhag, Vinit, Hodgkinson, Victoria L, Petris, Michael J

“…The ATP7A protein is a ubiquitous copper-transporting P-type ATPase that is mutated in the lethal pediatric disorder of copper metabolism, Menkes disease. The…”
Get full text

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene by Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John

“…The lack of actionable mutations in patients with non‐small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this…”
Get full text

Advances in atmospheric pressure PECVD: The influence of plasma parameters on film morphology by Hodgkinson, J.L., Sheel, D.W.

“…Atmospheric pressure (AP) PECVD systems have attracted considerable interest in recent years due to the significant benefits for large area, low cost…”
Get full text

Control of zinc oxide surface structure using combined atmospheric pressure-based CVD growth and plasma etching by Thomson, M., Hodgkinson, J.L., Sheel, D.W.

“…In photovoltaic thin film cells, a transparent conducting oxide (TCO) layer is required to transport current. The most common TCOs used are F:SnO2 (fluorine…”
Get full text

Evaluating the Impact of a Paediatric Burn Club for Children and Families Using Group Concept Mapping by Hodgkinson, Emma L., McKenzie, Alison, Johnson, Louise

“…Access to burn camps and clubs is cited as an essential element for children following a burn injury. In the Northern Regional Burns Service, this takes the…”
Get full text

American Urological Association (AUA) - 112th Annual Meeting (May 12-16, 2017 - Boston, Massachusetts, USA) by Hodgkinson, L

“…The American Urological Association (AUA) stands at the forefront of technology development and urological education for urologists and urological healthcare…”
Get full text

Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer by Carter, Louise, Rothwell, Dominic G, Mesquita, Barbara, Smowton, Christopher, Leong, Hui Sun, Fernandez-Gutierrez, Fabiola, Li, Yaoyong, Burt, Deborah J, Antonello, Jenny, Morrow, Christopher J, Hodgkinson, Cassandra L, Morris, Karen, Priest, Lynsey, Carter, Mathew, Miller, Crispin, Hughes, Andrew, Blackhall, Fiona, Dive, Caroline, Brady, Ged

“…Copy-number alterations detected in circulating tumor cells at time of diagnosis predict chemosensitive versus chemorefractory responses; however, CTCs…”
Get full text

Women's experiences of their pregnancy and postpartum body image: a systematic review and meta-synthesis by Hodgkinson, Emma L, Smith, Debbie M, Wittkowski, Anja

“…Pregnancy-related physical changes can have a significant impact on a woman's body image. There is no synthesis of existing literature to describe the…”
Get full text

The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer by Lallo, Alice, Frese, Kristopher K, Morrow, Christopher J, Sloane, Robert, Gulati, Sakshi, Schenk, Maximillian W, Trapani, Francesca, Simms, Nicole, Galvin, Melanie, Brown, Stewart, Hodgkinson, Cassandra L, Priest, Lynsey, Hughes, Adina, Lai, Zhongwu, Cadogan, Elaine, Khandelwal, Garima, Simpson, Kathryn L, Miller, Crispin, Blackhall, Fiona, O'Connor, Mark J, Dive, Caroline

“…Introduced in 1987, platinum-based chemotherapy remains standard of care for small cell lung cancer (SCLC), a most aggressive, recalcitrant tumor. Prominent…”
Get full text

Biosimilar Medicines Group - 14th Annual Medicines for Europe Conference (April 28-29, 2016 - London, UK) by Hodgkinson, L

“…Biotechnology has enabled the development of treatments for many diseases benefiting millions of people. Similar biologics or 'biosimilar' versions of…”
Get full text