Search Results - "Hodgkin, P"

T-cell stimuli independently sum to regulate an inherited clonal division fate by Marchingo, J. M., Prevedello, G., Kan, A., Heinzel, S., Hodgkin, P. D., Duffy, K. R.

“…In the presence of antigen and costimulation, T cells undergo a characteristic response of expansion, cessation and contraction. Previous studies have revealed…”
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single-cell pedigree analysis of alternative stochastic lymphocyte fates by Hawkins, E.D, Markham, J.F, McGuinness, L.P, Hodgkin, P.D

“…In contrast to most stimulated lymphocytes, B cells exposed to Toll-like receptor 9 ligands are nonself-adherent, allowing individual cells and families to be…”
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model of immune regulation as a consequence of randomized lymphocyte division and death times by Hawkins, E.D, Turner, M.L, Dowling, M.R, van Gend, C, Hodgkin, P.D

“…The magnitude of an adaptive immune response is controlled by the interplay of lymphocyte quiescence, proliferation, and apoptosis. How lymphocytes integrate…”
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Comparative evaluation of performance measures for shading correction in time‐lapse fluorescence microscopy by LIU, L., KAN, A., LECKIE, C., HODGKIN, P.D.

“…Summary Time‐lapse fluorescence microscopy is a valuable technology in cell biology, but it suffers from the inherent problem of intensity inhomogeneity due to…”
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Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes by Pham, K., Kan, A., Whitehead, L., Hennessy, R. J., Rogers, K., Hodgkin, P. D.

“…Recent studies using direct live cell imaging have reported that individual B lymphocytes have correlated transit times between their G1 and S/G2/M phases…”
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Predicting wellness among rural older Australians: A cross-sectional study by Hodgkin, Suzanne P, Warburton, Jeni, Hancock, Shaun

“…Introduction: Prior research on older people's wellbeing and quality of life has lacked clarity and consistency. Research examining older people's health has…”
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Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling by Lebois, M., Dowling, M. R., Gangatirkar, P., Hodgkin, P. D., Kile, B. T., Alexander, W. S., Josefsson, E. C.

“…Essentials We examined platelet survival in models of absent or enhanced thrombopoietin (TPO) signaling. Platelet lifespan is normal in transgenic mice with…”
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Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses by Hawkins, E.D., Turner, M.L., Wellard, C.J., Zhou, J.H.S., Dowling, M.R., Hodgkin, P.D.

“…Lymphocytes undergo a typical response pattern following stimulation in vivo : they proliferate, differentiate to effector cells, cease dividing and…”
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The effect of correlations on the population dynamics of lymphocytes by Wellard, C., Markham, J., Hawkins, E.D., Hodgkin, P.D.

“…Recent studies of the population dynamics of a system of lymphocytes in an in vitro immune response have reported strong correlations in cell division times,…”
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B cell differentiation and isotype switching is related to division cycle number by Hodgkin, P D, Lee, J H, Lyons, A B

“…The mature, resting immunoglobulin (Ig) M, IgD+ B lymphocyte can be induced by T cells to proliferate, switch isotype, and differentiate into Ig-secreting or…”
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Medicine, postmodernism, and the end of certainty by Hodgkin, Paul

“…[...]medicine has been glued together by a set of myths that everyone subscribed to: doctors battled against death and disease, we lived under the one true…”
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Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses by Tangye, Stuart G, Avery, Danielle T, Deenick, Elissa K, Hodgkin, Philip D

“…Humoral immune responses elicited after secondary exposure to immunizing Ag are characterized by robust and elevated reactivity of memory B cells that exceed…”
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Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation by Hodgkin, Philip D, Hasbold, Jhagvaral, Corcoran, Lynn M, Tarlinton, David M, Tangye, Stuart G

“…Naive B lymphocytes undergo isotype switching and develop into immunoglobulin-secreting cells to generate the appropriate class and amount of antibody…”
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B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells by Phan, Tri Giang, Amesbury, Michelle, Gardam, Sandra, Crosbie, Jeffrey, Hasbold, Jhagvaral, Hodgkin, Philip D, Basten, Antony, Brink, Robert

“…In both humans and animals, immunoglobulin (Ig)G autoantibodies are less frequent but more pathogenic than IgM autoantibodies, suggesting that controls over Ig…”
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A cellular calculus for signal integration by T cells by Hodgkin, Philip D, Gett, Amanda V

“…During an immune response numerous receptor-mediated signals delivered to T cells direct their proliferation, survival and differentiation. Here, we describe a…”
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Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival by Deenick, Elissa K, Gett, Amanda V, Hodgkin, Philip D

“…The outcome of Ag exposure is dictated by complex regulation of T cell proliferation. The rates of proliferation and survival are altered by numerous signals…”
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Activation rules: the two-signal theories of immune activation by Baxter, Alan G, Hodgkin, Philip D

“…Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental…”
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As moths to the flame. Primary care, technology, and the next 50 years by Hodgkin, P

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Isotype Switching by Human B Cells Is Division-Associated and Regulated by Cytokines by Tangye, Stuart G, Ferguson, Anthea, Avery, Danielle T, Ma, Cindy S, Hodgkin, Philip D

“…Isotype switching by murine B cells follows a pattern whereby the proportion of cells undergoing switching increases with division number and is regulated by…”
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Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester by Hasbold, J, Gett, AV, Rush, JS, Deenick, E, Avery, D, Jun, J, Hodgkin, PD

“…Mature T and B lymphocytes respond to receptor‐delivered signals received during and following activation. These signals regulate the rates of cell death,…”
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