Search Results - "Hodges, Craig"

Oocyte-Specific Differences in Cell-Cycle Control Create an Innate Susceptibility to Meiotic Errors by Nagaoka, So Iha, Hodges, Craig A., Albertini, David F., Hunt, Patricia Ann

“…Segregation of homologs at the first meiotic division (MI) is facilitated by crossovers and by a physical constraint imposed on sister kinetochores that…”
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Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models by Wei, Tuo, Sun, Yehui, Cheng, Qiang, Chatterjee, Sumanta, Traylor, Zachary, Johnson, Lindsay T., Coquelin, Melissa L., Wang, Jialu, Torres, Michael J., Lian, Xizhen, Wang, Xu, Xiao, Yufen, Hodges, Craig A., Siegwart, Daniel J.

“…Approximately 10% of Cystic Fibrosis (CF) patients, particularly those with CF transmembrane conductance regulator ( CFTR ) gene nonsense mutations, lack…”
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Neutrophil-mediated phagocytic host defense defect in myeloid Cftr-inactivated mice by Ng, Hang Pong, Zhou, Yun, Song, Kejing, Hodges, Craig A, Drumm, Mitchell L, Wang, Guoshun

“…Cystic fibrosis (CF) is a common and deadly inherited disease, caused by mutations in the CFTR gene that encodes a cAMP-activated chloride channel. One…”
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Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations by McHugh, Daniel R, Cotton, Calvin U, Hodges, Craig A

“…Many heritable genetic disorders arise from nonsense mutations, which generate premature termination codons (PTCs) in transcribed mRNA. PTCs ablate protein…”
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Dynamic expression of long noncoding RNAs reveals their potential roles in spermatogenesis and fertility by Wichman, Lauren, Somasundaram, Saigopal, Breindel, Christine, Valerio, Dana M, McCarrey, John R, Hodges, Craig A, Khalil, Ahmad M

“…Mammalian reproduction requires that males and females produce functional haploid germ cells through complex cellular differentiation processes known as…”
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Delivering on the promise of gene editing for cystic fibrosis by Hodges, Craig A., Conlon, Ronald A.

“…In this review, we describe a path for translation of gene editing into therapy for cystic fibrosis (CF). Cystic fibrosis results from mutations in the CFTR…”
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Impaired intestinal free fatty acid transport followed by chylomicron malformation, not pancreatic insufficiency, cause metabolic defects in cystic fibrosis by Teng, Lihong, Dedousis, Nikolaos, Adeshirlarijaney, Aneseh, Kanshana, Jitendra S., Liu, Min, Hodges, Craig A., Kohan, Alison B.

“…Intestinal disease is one of the earliest manifestations of cystic fibrosis (CF) in children and is closely tied to deficits in growth and nutrition, both of…”
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Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 Activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease by Kaji, Izumi, Roland, Joseph T., Watanabe, Masahiko, Engevik, Amy C., Goldstein, Anna E., Hodges, Craig A., Goldenring, James R.

“…Myosin VB (MYO5B) is an essential trafficking protein for membrane recycling in gastrointestinal epithelial cells. The inactivating mutations of MYO5B cause…”
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Moving beyond genetics: is FAM13A a major biological contributor in lung physiology and chronic lung diseases? by Corvol, Harriet, Hodges, Craig A, Drumm, Mitchell L, Guillot, Loïc

“…Variants in FAM13A have been found in genome-wide association studies (GWAS) to associate with lung function in the general population as well as in several…”
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HDAC6 depletion improves cystic fibrosis mouse airway responses to bacterial challenge by Rosenjack, Julie, Hodges, Craig A., Darrah, Rebecca J., Kelley, Thomas J.

“…The hypothesis of this study was that Hdac6 depletion would restore cystic fibrosis (CF) responses to bacterial challenge to more wild type profiles using a CF…”
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A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies by McHugh, Daniel R, Steele, Miarasa S, Valerio, Dana M, Miron, Alexander, Mann, Rachel J, LePage, David F, Conlon, Ronald A, Cotton, Calvin U, Drumm, Mitchell L, Hodges, Craig A

“…Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and…”
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Growth deficits in cystic fibrosis mice begin in utero prior to IGF-1 reduction by Darrah, Rebecca, Bederman, Ilya, Vitko, Megan, Valerio, Dana M, Drumm, Mitchell L, Hodges, Craig A

“…Growth deficits are common in cystic fibrosis (CF), but their cause is complex, with contributions from exocrine pancreatic insufficiency, pulmonary…”
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In vivo editing of lung stem cells for durable gene correction in mice by Sun, Yehui, Chatterjee, Sumanta, Lian, Xizhen, Traylor, Zachary, Sattiraju, Sandhya R, Xiao, Yufen, Dilliard, Sean A, Sung, Yun-Chieh, Kim, Minjeong, Lee, Sang M, Moore, Stephen, Wang, Xu, Zhang, Di, Wu, Shiying, Basak, Pratima, Wang, Jialu, Liu, Jing, Mann, Rachel J, LePage, David F, Jiang, Weihong, Abid, Shadaan, Hennig, Mirko, Martinez, Anna, Wustman, Brandon A, Lockhart, David J, Jain, Raksha, Conlon, Ronald A, Drumm, Mitchell L, Hodges, Craig A, Siegwart, Daniel J

“…In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. In this work, we…”
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Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland by Nedvetsky, Pavel I., Emmerson, Elaine, Finley, Jennifer K., Ettinger, Andreas, Cruz-Pacheco, Noel, Prochazka, Jan, Haddox, Candace L., Northrup, Emily, Hodges, Craig, Mostov, Keith E., Hoffman, Matthew P., Knox, Sarah M.

“…A fundamental question in development is how cells assemble to form a tubular network during organ formation. In glandular organs, tubulogenesis is a multistep…”
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Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice by Fan, Zhichao, Pitmon, Elise, Wen, Lai, Miller, Jacqueline, Ehinger, Erik, Herro, Rana, Liu, Wei, Chen, Ju, Mikulski, Zbigniew, Conrad, Douglas J, Marki, Alex, Orecchioni, Marco, Kumari, Puja, Zhu, Yanfang Peipei, Marcovecchio, Paola M, Hedrick, Catherine C, Hodges, Craig A, Rathinam, Vijay A, Wang, Kepeng, Ley, Klaus

“…Cystic fibrosis (CF) is an inherited life-threatening disease accompanied by repeated lung infections and multiorgan inflammation that affects tens of…”
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Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency by Chen, Anlu, Tiosano, Dov, Guran, Tulay, Baris, Hagit N, Bayram, Yavuz, Mory, Adi, Shapiro-Kulnane, Laura, Hodges, Craig A, Akdemir, Zeynep C, Turan, Serap, Jhangiani, Shalini N, van den Akker, Focco, Hoppel, Charles L, Salz, Helen K, Lupski, James R, Buchner, David A

“…Abstract Primary ovarian insufficiency (POI) is characterized by amenorrhea and loss or dysfunction of ovarian follicles prior to the age of 40. POI has been…”
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Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3 by McHugh, Daniel R, Cotton, Calvin U, Moss, Fraser J, Vitko, Megan, Valerio, Dana M, Kelley, Thomas J, Hao, Shuyu, Jafri, Anjum, Drumm, Mitchell L, Boron, Walter F, Stern, Robert C, McBennett, Kimberly, Hodges, Craig A

“…Gastrointestinal dysfunction in cystic fibrosis (CF) is a prominent source of pain among patients with CF. Linaclotide, a guanylate cyclase C (GCC) receptor…”
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The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection by Loeven, Nicole A, Perault, Andrew I, Cotter, Peggy A, Hodges, Craig A, Schwartzman, Joseph D, Hampton, Thomas H, Bliska, James B

“…Burkholderia cenocepacia is a member of the Burkholderia cepacia complex (Bcc), a group of bacteria with members responsible for causing lung infections in…”
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Consuming Genistein Improves Survival Rates in the Absence of Laxative in ΔF508-CF Female Mice by Lord, Ryan, Fairbourn, Nathan, Mylavarapu, Charisma, Dbeis, Ammer, Bowman, Taylor, Chandrashekar, Archana, Banayat, Tatum, Hodges, Craig A, Al-Nakkash, Layla

“…Genistein is a naturally occurring isoflavone found in soy. Genistein has been shown to increase the open probability of the most common cystic fibrosis (CF)…”
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Enhancing Cystic Fibrosis Immune Regulation by van Heeckeren, Anna M., Sutton, Morgan T., Fletcher, David R., Hodges, Craig A., Caplan, Arnold I., Bonfield, Tracey L.

“…In cystic fibrosis (CF), sustained infection and exuberant inflammation results in debilitating and often fatal lung disease. Advancement in CF therapeutics…”
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