Search Results - "Hodges, B.L."

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  1. 1
    Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease

    Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease by Cabrera-Salazar, M.A., Bercury, S.D., Ziegler, R.J., Marshall, J., Hodges, B.L., Chuang, W.-L., Pacheco, J., Li, L., Cheng, S.H., Scheule, R.K.

    Published in Experimental neurology (01-10-2010)
    “…Gaucher disease is caused by a deficit in the enzyme glucocerebrosidase. As a consequence, degradation of the glycolipids glucosylceramide (GluCer) and…”
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  2. 2
    Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity

    Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity by Osada, T, Yang, X Y, Hartman, Z C, Glass, O, Hodges, B L, Niedzwiecki, D, Morse, M A, Lyerly, H K, Amalfitano, A, Clay, T M

    Published in Cancer gene therapy (01-09-2009)
    “…Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in pre-clinical models, but…”
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  3. 3
    Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors

    Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors by Everett, R S, Hodges, B L, Ding, E Y, Xu, F, Serra, D, Amalfitano, A

    Published in Human gene therapy (10-12-2003)
    “…Adenoviral vectors from which the E1 region has been deleted ([E1(-)] Ad) are known to induce strong immune responses after systemic delivery. In this study we…”
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  4. 4
    Strain-specific rate of shutdown of CMV enhancer activity in murine liver confirmed by use of persistent [E1 −, E2b −] adenoviral vectors

    Strain-specific rate of shutdown of CMV enhancer activity in murine liver confirmed by use of persistent [E1 −, E2b −] adenoviral vectors by Everett, R.S, Evans, H.K, Hodges, B.L, Ding, E.Y, Serra, D.M, Amalfitano, A

    Published in Virology (New York, N.Y.) (20-07-2004)
    “…The systemic delivery of [E1 −] adenoviral (Ad) vectors encoding a transgene results in efficient viral uptake and abundant transgene expression in the liver…”
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  5. 5
    Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice

    Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice by Ding, E Y, Hodges, B L, Hu, H, McVie-Wylie, A J, Serra, D, Migone, F K, Pressley, D, Chen, Y T, Amalfitano, A

    Published in Human gene therapy (20-05-2001)
    “…Glycogen storage disease type II (GSD-II) is a lethal, autosomal recessive metabolic myopathy caused by a lack of acid-alpha-glucosidase (GAA) activity in the…”
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