Search Results - "Hodek, P."

Effect of low-density lipoprotein addition to soybean lecithin-based extenders on bull spermatozoa following freezing-thawing - preliminary results by Šimoník, O., Rajmon, R., Stádník, L., Šichtař, J., Beran, J., Ducháček, J., Hodek, P., Trefil, P.

“…Soybean lecithin-based extenders represent an alternative to extenders containing egg yolk, but there has been discussion about their cryoprotective efficacy…”
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Chemopreventive compounds—View from the other side by Hodek, P., Křížková, J., Burdová, K., Šulc, M., Kizek, R., Hudeček, J., Stiborová, M.

“…Increasing attention is being paid to the possibility of applying chemopreventive agents for the protection of individuals from cancer risk. The beneficial…”
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Rabbit liver microsomal system: study of interaction with two model N-nitrosamines and their metabolism by Sulc, M, Kubícková, B, Máslová, V, Hodek, P

“…Rabbit liver microsomes of control (non-treated) or animals induced either by ethanol (EtOH) or phenobarbital (PB) were incubated with N-nitrosodimethylamine…”
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Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 by Hodek, Petr, Trefil, Pavel, Stiborová, Marie

“…Flavonoids represent a group of phytochemicals exhibiting a wide range of biological activities arising mainly from their antioxidant properties and ability to…”
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Evaluation of 3-azidiamantane as photoaffinity probe of cytochrome P450 by Hodek, P, Smrcek, S

“…3-azidiamantane (DIA-N2) has been shown to be a photolabile carbene-generating probe interacting specifically with cytochrome P450 (P450) active centre. To…”
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Sex reversed chicks (Gallus domesticus) hatched from eggs treated with aromatase inhibitor YM511 by Trefil, P., Mičáková, A., Mucksová, J., Poplštein, M., Brillard, J.-P., Hodek, P.

“…The objectives of this study were to assess post-hatch development of chickens treated in ovo with the aromatase inhibitor YM511. A total of 137 eggs coming…”
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Effect of anti-PAIIl antibody on Pseudomonas aeruginosa infection in cellular and animal models by Kubickova, B., Hadrabova, J., Vaskova, L., Wimmerova, M., Stiborova, M., Hodek, P.

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Sudan I is a potential carcinogen for humans: Evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes by STIBOROVA, Marie, MARTINEK, Vaclav, RYDLOVA, Helena, HODEK, Petr, FREI, Eva

“…1-Phenylazo-2-hydroxynaphthol (Sudan I, C.I. Solvent Yellow 14) is a liver and urinary bladder carcinogen in mammals. We compared the ability of hepatic…”
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Effects of α - naphthoflavone on body growth and gonad development in chickens (Gallus domesticus) by Trefil, P., Mičáková, A., Stiborová, M., Poplštein, M., Brillard, J. P, Hodek, P.

“…The aim of this study was to investigate the effects of prolonged oral administration of α -naphthoflavone on somatic and germinal development in male and…”
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Mycotoxin ochratoxin A decreases cytochrome P450-mediated detoxication of carcinogenic aristolochic acid thereby increases its genotoxic potential in rats in vivo by Barta, F., Levova, K., Hodek, P., Frei, E., Arlt, V.M., Schmeiser, H.H., Stiborova, M.

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Treatment with a mixture of aristolochic acid I and II influences their genotoxicity and expression of biotransformation enzymes in rats in vivo by Stiborova, M., Barta, F., Dracinska, H., Hudecova, A., Hodek, P., Balogova, M., Mraz, J., Duskova, S., Schmeiser, H.H., Arlt, V.M.

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Does dihydromyricetin impact on alcohol metabolism by Skotnicová, A, Boubínová, G, Boštíková, Z, Dušková, Š, Šulc, M, Kutinová-Canová, N, Mráz, J, Hodek, P

“…Dihydromyricetin (DHM) is a natural flavonoid showing several health promoting effects such as protective activity during severe alcohol intoxication. The…”
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Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers by Stiborová, Marie, Martínek, Václav, Rýdlová, Helena, Koblas, Tomáš, Hodek, Petr

“…Cytochrome P450 1A1 (CYP1A1) is one of the most important enzymes implicated in the metabolic activation of carcinogens. To date, there is still conflicting…”
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Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid‐DNA adducts found in patients with urothelial cancer by Stiborová, Marie, Frei, Eva, Hodek, Petr, Wiessler, Manfred, Schmeiser, Heinz H.

“…Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans…”
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Probing the cytochrome P-450 2B1 active site with diamantoid compounds by Hodek, P, Burkhard, J, Janků, J

“…Hydrocarbone diamantane has been shown to be a specific substrate with a high affinity for the binding site of PB-inducible cytochrome P-450 2B1 (Hodek et al…”
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Evaluation of Isoflavone Aglycon and Glycoside Distribution in Soy Plants and Soybeans by Fast Column High-Performance Liquid Chromatography Coupled with a Diode-Array Detector by Klejdus, Bořivoj, Mikelová, Radka, Petrlová, Jitka, Potěšil, David, Adam, Vojtěch, Stiborová, Marie, Hodek, Petr, Vacek, Jan, Kizek, René, Kubáň, Vlastimil

“…An ultrafast HPLC/UV−vis DAD method working at 254 nm was applied for the determination of isoflavone aglycons and glycosides (genistin, genistein, daidzein,…”
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Determination of isoflavones in soy bits by fast column high-performance liquid chromatography coupled with UV–visible diode-array detection by Klejdus, Bořivoj, Mikelová, Radka, Petrlová, Jitka, Potěšil, David, Adam, Vojtěch, Stiborová, Marie, Hodek, Petr, Vacek, Jan, Kizek, René, Kubáň, Vlastimil

“…A fast determination of isoflavones (genistin, genistein, daidzein, daidzin, glycitin, glycitein, ononin, formononetin, sissotrin and biochanin A) by…”
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The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation by Sulc, Miroslav, Hodek, Petr, Stiborová, Marie

“…The interaction of carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosomethylaniline (NMA) with cytochromes P450 (CYP), CYP2B4, CYP2E1 and CYP3A6, and…”
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The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen by Stiborová, Marie, Sopko, Bruno, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Hudeček, Jiří

“…Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the…”
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Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver by Stiborova, Marie, Mares, Jaroslav, Levova, Katerina, Pavlickova, Jana, Barta, Frantisek, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H

“…The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid nephropathy (AAN), Balkan endemic…”
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