Search Results - "Hocking, Lynne J."

Autophagy: A new player in skeletal maintenance? by Hocking, Lynne J, Whitehouse, Caroline, Helfrich, Miep H

“…Imbalances between bone resorption and formation lie at the root of disorders such as osteoporosis, Paget's disease of bone (PDB), and osteopetrosis. Recently,…”
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Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study by van Hecke, Oliver, Hocking, Lynne J, Torrance, Nicola, Campbell, Archie, Padmanabhan, Sandosh, Porteous, David J, McIntosh, Andrew M, Burri, Andrea V, Tanaka, Haruka, Williams, Frances M K, Smith, Blair H

“…Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). They occur together more frequently than…”
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Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants by Nagy, Reka, Boutin, Thibaud S, Marten, Jonathan, Huffman, Jennifer E, Kerr, Shona M, Campbell, Archie, Evenden, Louise, Gibson, Jude, Amador, Carmen, Howard, David M, Navarro, Pau, Morris, Andrew, Deary, Ian J, Hocking, Lynne J, Padmanabhan, Sandosh, Smith, Blair H, Joshi, Peter, Wilson, James F, Hastie, Nicholas D, Wright, Alan F, McIntosh, Andrew M, Porteous, David J, Haley, Chris S, Vitart, Veronique, Hayward, Caroline

“…The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic,…”
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Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis by McIntosh, Andrew M, Hall, Lynsey S, Zeng, Yanni, Adams, Mark J, Gibson, Jude, Wigmore, Eleanor, Hagenaars, Saskia P, Davies, Gail, Fernandez-Pujals, Ana Maria, Campbell, Archie I, Clarke, Toni-Kim, Hayward, Caroline, Haley, Chris S, Porteous, David J, Deary, Ian J, Smith, Daniel J, Nicholl, Barbara I, Hinds, David A, Jones, Amy V, Scollen, Serena, Meng, Weihua, Smith, Blair H, Hocking, Lynne J

“…Chronic pain is highly prevalent and a significant source of disability, yet its genetic and environmental risk factors are poorly understood. Its relationship…”
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Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome‐Wide Association Study by Orozco, Gisela, Viatte, Sebastien, Bowes, John, Martin, Paul, Wilson, Anthony G., Morgan, Ann W., Steer, Sophia, Wordsworth, Paul, Hocking, Lynne J., Barton, Anne, Worthington, Jane, Eyre, Stephen

“…Objective The number of confirmed rheumatoid arthritis (RA) loci currently stands at 32, but many lines of evidence indicate that expansion of existing…”
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Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking by Scott, Ian C, Seegobin, Seth D, Steer, Sophia, Tan, Rachael, Forabosco, Paola, Hinks, Anne, Eyre, Stephen, Morgan, Ann W, Wilson, Anthony G, Hocking, Lynne J, Wordsworth, Paul, Barton, Anne, Worthington, Jane, Cope, Andrew P, Lewis, Cathryn M

“…The improved characterisation of risk factors for rheumatoid arthritis (RA) suggests they could be combined to identify individuals at increased disease risks…”
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Brief Report: Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta‐Analysis of Genome‐Wide Data by McAllister, Kate, Yarwood, Annie, Bowes, John, Orozco, Gisela, Viatte, Sebastian, Diogo, Dorothée, Hocking, Lynne J., Steer, Sophia, Wordsworth, Paul, Wilson, A. G., Morgan, Ann W., Kremer, Joel M., Pappas, Dimitrios, Gregersen, Peter, Klareskog, Lars, Plenge, Robert, Barton, Anne, Greenberg, Jeffrey, Worthington, Jane, Eyre, Stephen

“…Objective A recent high‐density fine‐mapping (ImmunoChip) study of genetic associations in rheumatoid arthritis (RA) identified 14 risk loci with validated…”
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Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study by Marioni, Riccardo E., Batty, G. David, Hayward, Caroline, Kerr, Shona M., Campbell, Archie, Hocking, Lynne J., Porteous, David J., Visscher, Peter M., Deary, Ian J.

“…Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to…”
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The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies by Judson, Robert N, Wackerhage, Henning, Hughes, Alun, Mavroeidi, Alexandra, Barr, Rebecca J, Macdonald, Helen M, Ratkevicius, Aivaras, Reid, David M, Hocking, Lynne J

“…Falls among elderly people is a major issue in public health, causing debilitating outcomes including fracture. The identification of genetic risk factors for…”
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Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts by Hocking, Lynne J., Mellis, David J., McCabe, Paul S., Helfrich, Miep H., Rogers, Michael J.

“…► Interaction between SQSTM1 and ALFY in human osteoclasts was identified by proteomic analysis. ► Expression of ALFY in human osteoclasts was confirmed by…”
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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism by Clarke, Toni-Kim, Zeng, Yanni, Navrady, Lauren, Xia, Charley, Haley, Chris, Campbell, Archie, Navarro, Pau, Amador, Carmen, Adams, Mark J., Howard, David M., Soler, Aleix, Hayward, Caroline, Thomson, Pippa A., Smith, Blair H., Padmanabhan, Sandosh, Hocking, Lynne J., Hall, Lynsey S., Porteous, David J., Deary, Ian J., McIntosh, Andrew M.

“…Background: Stressful life events (SLEs) and neuroticism are risk factors for major depressive disorder (MDD). However, SLEs and neuroticism are heritable and…”
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Bone remodelling at a glance by Crockett, Julie C, Rogers, Michael J, Coxon, Fraser P, Hocking, Lynne J, Helfrich, Miep H

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Identification of a Major Locus for Paget's Disease on Chromosome 10p13 in Families of British Descent by Lucas, Gavin JA, Riches, Phillip L, Hocking, Lynne J, Cundy, Tim, Nicholson, Geoff C, Walsh, John P, Ralston, Stuart H

“…Mutations of SQSTM1 are an important cause of PDB, but other genes remain to be discovered. A major susceptibility locus for PDB was identified on chromosome…”
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Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness by SMITH, Blair H, CAMPBELL, Archie, HOCKING, Lynne J, WISELY, Lucy, FORD, Ian, LINDSAY, Robert S, MORTON, Robin, PALMER, Colin N. A, DOMINICZAK, Anna F, PORTEOUS, David J, MORRIS, Andrew D, LINKSTED, Pamela, FITZPATRICK, Bridie, JACKSON, Cathy, KERR, Shona M, DEARY, Ian J, MACLNTYRE, Donald J, CAMPBELL, Harry, MCGILCHRIST, Mark

“…GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98…”
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Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease by Johnson, Michael R, Shkura, Kirill, Langley, Sarah R, Delahaye-Duriez, Andree, Srivastava, Prashant, Hill, W David, Rackham, Owen J L, Davies, Gail, Harris, Sarah E, Moreno-Moral, Aida, Rotival, Maxime, Speed, Doug, Petrovski, Slavé, Katz, Anaïs, Hayward, Caroline, Porteous, David J, Smith, Blair H, Padmanabhan, Sandosh, Hocking, Lynne J, Starr, John M, Liewald, David C, Visconti, Alessia, Falchi, Mario, Bottolo, Leonardo, Rossetti, Tiziana, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Grote, Alexander, Helmstaedter, Christoph, Becker, Albert J, Kaminski, Rafal M, Deary, Ian J, Petretto, Enrico

“…Impairment of cognitive function is a common feature of many neurodevelopmental disorders. Systems genetics analysis in the brain uncovered a convergent gene…”
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Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study by Goodson, Nicola J., Smith, Blair H., Hocking, Lynne J., McGilchrist, Mark M., Dominiczak, Anna F., Morris, Andrew, Porteous, David J., Goebel, Andreas

“…The prevalence of cardiovascular risk factors and metabolic syndrome are increased in chronic pain. This may contribute to the reduced life expectancy in these…”
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Molecular genetic contributions to socioeconomic status and intelligence by Marioni, Riccardo E., Davies, Gail, Hayward, Caroline, Liewald, Dave, Kerr, Shona M., Campbell, Archie, Luciano, Michelle, Smith, Blair H., Padmanabhan, Sandosh, Hocking, Lynne J., Hastie, Nicholas D., Wright, Alan F., Porteous, David J., Visscher, Peter M., Deary, Ian J.

“…Education, socioeconomic status, and intelligence are commonly used as predictors of health outcomes, social environment, and mortality. Education and…”
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Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP by Wigmore, Eleanor M., Hafferty, Jonathan D., Hall, Lynsey S., Howard, David M., Clarke, Toni-Kim, Fabbri, Chiara, Lewis, Cathryn M., Uher, Rudolf, Navrady, Lauren B., Adams, Mark J., Zeng, Yanni, Campbell, Archie, Gibson, Jude, Thomson, Pippa A., Hayward, Caroline, Smith, Blair H., Hocking, Lynne J., Padmanabhan, Sandosh, Deary, Ian J., Porteous, David J., Mors, Ole, Mattheisen, Manuel, Nicodemus, Kristin K., McIntosh, Andrew M.

“…Antidepressants demonstrate modest response rates in the treatment of major depressive disorder (MDD). Despite previous genome-wide association studies (GWAS)…”
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Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing by Hocking, Lynne J, Andrews, Claire, Armstrong, Christine, Ansari, Morad, Baty, David, Berg, Jonathan, Bradley, Therese, Clark, Caroline, Diamond, Austin, Doherty, Jill, Lampe, Anne, McGowan, Ruth, Moore, David J, O'Sullivan, Dawn, Purvis, Andrew, Santoyo-Lopez, Javier, Westwood, Paul, Abbott, Michael, Williams, Nicola, Aitman, Timothy J, Miedzybrodzka, Zosia

“…NHS genetics centres in Scotland sought to investigate the Genomics England 100,000 Genomes Project diagnostic utility to evaluate genome sequencing for in…”
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A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder by Zeng, Yanni, Navarro, Pau, Fernandez-Pujals, Ana M, Hall, Lynsey S, Clarke, Toni-Kim, Thomson, Pippa A, Smith, Blair H, Hocking, Lynne J, Padmanabhan, Sandosh, Hayward, Caroline, MacIntyre, Donald J, Wray, Naomi R, Deary, Ian J, Porteous, David J, Haley, Chris S, McIntosh, Andrew M

“…Abstract Background Genome-wide association studies (GWASs) of major depressive disorder (MDD) have identified few significant associations. Testing the…”
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