Search Results - "Hockin, Matthew"

A Model for the Stoichiometric Regulation of Blood Coagulation by Hockin, Matthew F., Jones, Kenneth C., Everse, Stephen J., Mann, Kenneth G.

“…We have developed a model of the extrinsic blood coagulation system that includes the stoichiometric anticoagulants. The model accounts for the formation,…”
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A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in Mice by HALDAR, Malay, HEDBERG, Matthew L, HOCKIN, Matthew F, CAPECCHI, Mario R

“…Previously, we reported modeling synovial sarcomas in mice by conditionally expressing the human t(X;18) translocation-derived SYT-SSX2 fusion protein in…”
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The Crystal Structure of Activated Protein C-Inactivated Bovine Factor Va: Implications for Cofactor Function by Adams, Ty E., Hockin, Matthew F., Mann, Kenneth G., Everse, Stephen J., Esmon, Charles T.

“…In vertebrate hemostasis, factor Va serves as the cofactor in the prothrombinase complex that results in a 300,000-fold increase in the rate of thrombin…”
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Optimization of Volumetric Computed Tomography for Skeletal Analysis of Model Genetic Organisms by Vasquez, Sergio X., Hansen, Mark S., Bahadur, Ali N., Hockin, Matthew F., Kindlmann, Gordon L., Nevell, Lisa, Wu, Isabel Q., Grunwald, David J., Weinstein, David M., Jones, Greg M., Johnson, Christopher R., Vandeberg, John L., Capecchi, Mario R., Keller, Charles

“…Forward and reverse genetics now allow researchers to understand embryonic and postnatal gene function in a broad range of species. Although some genetic…”
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A Model Describing the Inactivation of Factor Va by APC:  Bond Cleavage, Fragment Dissociation, and Product Inhibition by Hockin, Matthew F, Cawthern, Kevin M, Kalafatis, Michael, Mann, Kenneth G

“…The inactivation of factor Va is a complex process which includes bond cleavage (at three sites) and dissociation of the A2N·A2C peptides, with intermediate…”
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Enhanced chromosome extraction from cells using a pinched flow microfluidic device by Feng, Haidong, Hockin, Matthew, Zhang, Shuhua, Capecchi, Mario, Gale, Bruce, Sant, Himanshu

“…Extraction and purification of intact chromosomes are critical sample preparation steps for transchromosomic research and other applications. The commonly used…”
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Protein C Activation and Factor Va Inactivation on Human Umbilical Vein Endothelial Cells by Hockin, Matthew F, Kalafatis, Michael, Shatos, Marie, Mann, Kenneth G

“…The inactivation of factor Va was examined on primary cultures of human umbilical vein endothelial cells (HUVECs), either after addition of activated protein C…”
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Size and shape based chromosome separation in the inertial focusing device by Feng, Haidong, Hockin, Matthew, Capecchi, Mario, Gale, Bruce, Sant, Himanshu

“…In this paper, we use a spiral channel inertial focusing device for isolation and purification of chromosomes, which are highly asymmetric. The method…”
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Self-Association of Human Protein S by Pauls, Jonathan E. D, Hockin, Matthew F, Long, George L, Mann, Kenneth G

“…Protein S functions as a cofactor with activated protein C in the down-regulation of the blood coagulation cascade. In vitro studies have historically produced…”
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Activated Protein C Cleavage of Factor Va Leads to Dissociation of the A2 Domain by Mann, Kenneth G., Hockin, Matthew F., Begin, Kelly J., Kalafatis, Michael

“…The products of cleavage of bovine factor Va by activated protein C (APC) in the presence and absence of phospholipid (25% phosphatidylserine, 75%…”
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Predicting Thrombosis in Factor VLeiden Heterozygotes by Everse, Stephen J., Orfeo, Thomas, Brummel-Ziedins, Kathleen E., Hockin, Matthew F., Mann, Kenneth G.

“…Factor VLeiden (G1691A;R506Q) is an autosomal dominant allele displaying high prevalence (3–7%) in the United States Caucasian population and a high incidence…”
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