Search Results - "Hockett, D"

Cytochrome P-450 Polymorphisms and Response to Clopidogrel by Mega, Jessica L, Close, Sandra L, Wiviott, Stephen D, Shen, Lei, Hockett, Richard D, Brandt, John T, Walker, Joseph R, Antman, Elliott M, Macias, William, Braunwald, Eugene, Sabatine, Marc S

“…The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel…”
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Kinetics of T Cell Receptor β , γ , and δ Rearrangements during Adult Thymic Development: T Cell Receptor Rearrangements are Present in CD44+CD25+Pro-T Thymocytes by Capone, Myriam, Hockett, Richard D., Zlotnik, Albert

“…We performed a comprehensive analysis of T cell receptor (TCR) γ rearrangements in T cell precursors of the mouse adult thymus. Using a sensitive quantitative…”
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Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues by Bucy, R P, Hockett, R D, Derdeyn, C A, Saag, M S, Squires, K, Sillers, M, Mitsuyasu, R T, Kilby, J M

“…Previous studies proposed a dynamic, steady-state relationship between HIV-mediated cell killing and T-cell proliferation, whereby highly active antiretroviral…”
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A Phase II Trial of Pemetrexed in Advanced Breast Cancer: Clinical Response and Association with Molecular Target Expression by GOMEZ, Henry L, SANTILLANA, Sergio L, HANAUSKE, Axel R, VALLEJOS, Carlos S, VELARDE, Raul, SANCHEZ, Juvenal, XINPENG WANG, BAUER, Nancy L, HOCKETT, Richard D, CHEN, Victor J, NIYIKIZA, Clet

“…Purpose: This phase II trial of pemetrexed explored potential correlations between treatment outcome (antitumor activity) and molecular target expression…”
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T Cell Receptor Gene Deletion Circles Identify Recent Thymic Emigrants in the Peripheral T Cell Pool by Kong, Fan-kun, Chen-lo H. Chen, Six, Adrien, Hockett, Richard D., Cooper, Max D.

“…Progenitor cells undergo T cell receptor (TCR) gene rearrangements during their intrathymic differentiation to become T cells. Rearrangements of the variable…”
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Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA by Hockett, R D, Kilby, J M, Derdeyn, C A, Saag, M S, Sillers, M, Squires, K, Chiz, S, Nowak, M A, Shaw, G M, Bucy, R P

“…Quantitative analysis of the relationship between virus expression and disease outcome has been critical for understanding HIV-1 pathogenesis. Yet the amount…”
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Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel: Relationship to Pharmacokinetic, Pharmacodynamic, and Clinical Outcomes by MEGA, Jessica L, CLOSE, Sandra L, SABATINE, Marc S, WIVIOTT, Stephen D, LEI SHEN, HOCKETT, Richard D, BRANDT, John T, WALKER, Joseph R, ANTMAN, Elloitt M, MACIAS, William L, BRAUNWALD, Eugene

“…Both clopidogrel and prasugrel require biotransformation to active metabolites by cytochrome P450 (CYP) enzymes. Among persons treated with clopidogrel,…”
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Differential Expression of Fas Ligand in Th1 and Th2 Cells Is Regulated by Early Growth Response Gene and NF-AT Family Members by Dzialo-Hatton, Robin, Milbrandt, Jeffrey, Hockett, Richard D., Jr, Weaver, Casey T

“…Inducible expression of Fas ligand (CD95 ligand) by activated T cells and the resulting apoptosis of CD95-bearing cells is a critical component of peripheral T…”
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Interleukin-2 Expression by a Subpopulation of Primary T Cells Is Linked to Enhanced Memory/Effector Function by Saparov, Arman, Wagner, Fred H, Zheng, Rui, Oliver, James R, Maeda, Hiroko, Hockett, Richard D, Weaver, Casey T

“…Single cell studies have identified intraclonal heterogeneity of cytokine production by activated T cells. To investigate implications of cytokine…”
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Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix Targeted Genotyping System by Dumaual, Carmen, Miao, Xin, Daly, Thomas M, Bruckner, Carsten, Njau, Reuben, Fu, Dong-Jing, Close-Kirkwood, Sandra, Bauer, Nancy, Watanabe, Nancy, Hardenbol, Paul, Hockett, Richard D

“…The combined effects of multiple polymorphisms in several drug-metabolizing enzyme and transporter genes can contribute to considerable interindividual…”
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Effect of Lipopolysaccharide and Inflammatory Cytokines on Interleukin-6 Production by Healthy Human Gingival Fibroblasts by KENT, L. W, RAHEMTULLA, F, HOCKETT, R. D, GILLELAND, R. C, MICHALEK, S. M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport by Daly, Thomas M, Dumaual, Carmen M, Miao, Xin, Farmen, Mark W, Njau, Reuben K, Fu, Dong-Jing, Bauer, Nancy L, Close, Sandra, Watanabe, Nancy, Bruckner, Carsten, Hardenbol, Paul, Hockett, Richard D

“…Drug metabolism is a multistep process by which the body disposes of xenobiotic agents such as therapeutic drugs. Genetic variation in the enzymes involved in…”
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Alternative promoters and exons, somatic mutation and deregulation of the Bcl‐2‐Ig fusion gene in lymphoma by Seto, M., Jaeger, U., Hockett, R. D., Graninger, W., Bennett, S., Goldman, P., Korsmeyer, S. J.

“…The most common translocation in human lymphoma, the t(14;18)(q32;q21), generates heterogeneous 4.2‐7.2 kb Bcl‐2‐immunoglobulin (Ig) chimeric mRNAs resulting…”
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A generalized strategy for designing 19F/1H dual-frequency MRI coil for small animal imaging at 4.7 Tesla by Hu, Lingzhi, Hockett, Frank D., Chen, Junjie, Zhang, Lei, Caruthers, Shelton D., Lanza, Gregory M., Wickline, Samuel A.

“…Purpose: To propose and test a universal strategy for building 19F/1H dual‐frequency RF coil that permits multiple coil geometries. Materials and Methods: The…”
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The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein by MCGUIRE, E. A, HOCKETT, R. D, POLLOCK, K. M, BARTHOLDI, M. F, O'BRIEN, S. J, KORSMEYER, S. J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A generalized strategy for designing (19)F/(1)H dual-frequency MRI coil for small animal imaging at 4.7 Tesla by Hu, Lingzhi, Hockett, Frank D, Chen, Junjie, Zhang, Lei, Caruthers, Shelton D, Lanza, Gregory M, Wickline, Samuel A

“…To propose and test a universal strategy for building (19) F/(1) H dual-frequency RF coil that permits multiple coil geometries. The feasibility to design (19)…”
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Regulation of Laboratory-Developed Tests: The Case for Utilizing Professional Associations by Hockett, R D, Close, S L

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Evaluation of Distinct Blood Lymphocyte Populations in Human Immunodeficiency Virus Type 1—Infected Subjects in the Absence or Presence of Effective Therapy by Derdeyn, Cynthia A., Kilby, J. Michael, Miralles, G. Diego, Li, Li-Fang, Sfakianos, Greg, Saag, Michael S., Hockett, Richard D., Bucy, R. Pat

“…Virus reservoirs can persist in human immunodeficiency virus type 1 (HIV-1)—infected subjects despite effective plasma virus suppression. To compare viral…”
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In Vitro Demonstration Using 19F Magnetic Resonance to Augment Molecular Imaging With Paramagnetic Perfluorocarbon Nanoparticles at 1.5 Tesla by Caruthers, Shelton D, Neubauer, Anne M, Hockett, Frank D, Lamerichs, Rolf, Winter, Patrick M, Scott, Michael J, Gaffney, Patrick J, Wickline, Samuel A, Lanza, Gregory M

“…OBJECTIVES:This study explored the use of F spectroscopy and imaging with targeted perfluorocarbon nanoparticles for the simultaneous identification of…”
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Precision Profiling and Components of Variability Analysis for Affymetrix Microarray Assays Run in a Clinical Context by Daly, Thomas M., Dumaual, Carmen M., Dotson, Crystal A., Farmen, Mark W., Kadam, Sunil K., Hockett, Richard D.

“…Although gene expression profiling using microarray technology is widely used in research environments, adoption of microarray testing in clinical laboratories…”
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