Search Results - "Hockenbery, DM"

BCL-X L Dimerization by Three-dimensional Domain Swapping by O'Neill, Jason W., Manion, Michael K., Maguire, Brendan, Hockenbery, David M.

“…Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death…”
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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3 by Hockenbery, David M, Tzung, Shie-Pon, Kim, Kristine M, Basañez, Gorka, Giedt, Chris D, Simon, Julian, Zimmerberg, Joshua, Zhang, Kam Y. J

“…The Bcl-2-related survival proteins confer cellular resistance to a wide range of agents. Bcl-xL-expressing hepatocyte cell lines are resistant to tumour…”
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Abstract P5-01-02: Multimodality molecular imaging with dynamic 18F-fluorodeoxyglucose positron emission tomography (FDG PET) and MRI to evaluate response and resistance to neoadjuvant chemotherapy (NAC) by Specht, JM, Partridge, S, Chai, X, Novakova, A, Peterson, L, Shields, A, Guenthoer, J, Linden, HM, Gralow, JR, Gadi, V, Korde, L, Hills, D, Hsu, L, Hockenbery, DM, Kinahan, P, Mankoff, DA, Porter, PL

“…Abstract Background: Using quantitative FDG PET to measure glucose metabolism and perfusion, and dynamic contrast-enhanced (DCE) MRI to measure perfusion, we…”
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Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy by O'Neill, Jason, Manion, Michael, Schwartz, Pam, Hockenbery, David M.

“…Cancer cells with elevated levels of BCL-2 and related survival proteins are broadly resistant to cytotoxic agents. Antisense oligodeoxynucleotides, and more…”
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Targeting Bcl-2 Related Proteins in Cancer Therapy by Manion, Michael K., Hockenbery, David

“…The BCL-2 family proteins are attractive targets for drug design. As pivotal regulators of apoptotic cell death, the logic of manipulating BCL-2 functions for…”
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Bcl-2 functions in an antioxidant pathway to prevent apoptosis by Hockenbery, D M, Oltvai, Z N, Yin, X M, Milliman, C L, Korsmeyer, S J

“…Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality. Bcl-2 is localized to intracellular sites of oxygen free radical…”
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A mitochondrial Achilles' heel in cancer? by Hockenbery, David M.

“…Mitochondria are principal actors in apoptosis as central hubs for diverse apoptotic signals. A new paper demonstrates the therapeutic potential of directly…”
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Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line by Mancini, Mariangela, Anderson, Benjamin O., Caldwell, Elizabeth, Sedghinasab, Monireh, Paty, Philip B., Hockenbery, David M.

“…Herbimycin A, a tyrosine kinase inhibitor, induces cellular differentiation and delayed apoptosis in Colo-205 cells, a poorly differentiated human colon…”
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bcl-2, a novel regulator of cell death by Hockenbery, D M

“…The bcl-2 gene product, a 25 kDa membrane protein residing at mitochondrial, microsomal and nuclear membrane sites within many cell types, is a broad and…”
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BCL2 Protein is Topographically Restricted in Tissues Characterized by Apoptotic Cell Death by Hockenbery, David M., Zutter, Mary, Hickey, William, Nahm, Moon, Korsmeyer, Stanley J.

“…The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of…”
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Reactive oxygen species in chick hair cells after gentamicin exposure in vitro by Hirose, Keiko, Hockenbery, David M., Rubel, Edwin W.

“…Reactive oxygen species have been invoked as a causative agent of cell death in many different developmental and pathological states. The presence of free…”
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bcl-2 in cancer, development and apoptosis by Hockenbery, David M.

“…The bcl-2 gene provides a window on the basic cellular machinery of apoptosis or programmed cell death, a process involved in virtually all biologic events in…”
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Biophysical Characterization of Recombinant Human Bcl-2 and Its Interactions with an Inhibitory Ligand, Antimycin A by Kim, Kristine M, Giedt, Chris D, Basañez, Gorka, O'Neill, Jason W, Hill, John J, Han, Yi-Hong, Tzung, Shie-Pon, Zimmerberg, Joshua, Hockenbery, David M, Zhang, Kam Y. J

“…Apoptosis is an essential physiological process, regulated by the family of Bcl-2-related proteins. However, the molecular mechanism by which Bcl-2 regulates…”
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A death in the family: Stanley J Korsmeyer (1950-2005) by Hockenbery, D M, Nuñez, G

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Induction of Apoptosis Using Inhibitors of Lysophosphatidic Acid Acyltransferase-β and Anti-CD20 Monoclonal Antibodies for Treatment of Human Non-Hodgkin's Lymphomas by PAGEL, John M, LAUGEN, Christian, BONHAM, Lynn, HACKMAN, Robert C, HOCKENBERY, David M, BHATT, Rama, HOLLENBACK, David, CAREW, Heather, SINGER, Jack W, PRESS, Oliver W

“…Purpose: Lysophosphatidic acid acyltransferase-β (LPAAT-β) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product,…”
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Nailing Down a Link between Tuberin and Renal Cysts by Hockenbery, David M.

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Bcl-2-related proteins as drug targets by O'Neill, Jason W, Hockenbery, David M

“…The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to…”
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A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system by Erxleben, Holger A, Manion, Michael K, Hockenbery, David M, Scampavia, Louis, Ruzicka, Jaromir

“…Monitoring extracellular acidification rates (ECARs) is important for the study of cellular activities, since it allows for the evaluation of factors that…”
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Primitive human hematopoietic precursors express Bcl-x but not Bcl-2 by Park, JR, Bernstein, ID, Hockenbery, DM

“…Bcl-2 and its homologue, bcl-xL, encode membrane-associated proteins that suppress programmed cell death of hematopoietic cell lines after growth factor…”
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Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene by Tzung, SP, Fausto, N, Hockenbery, DM

“…Induction of Bcl-2 and Bcl-x has been demonstrated in mitogen-stimulated lymphocytes in vitro, suggesting that these two apoptosis modulators may also play a…”
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