Search Results - "Hockemeyer, Dirk"

Control of telomerase action at human telomeres by Hockemeyer, Dirk, Collins, Kathleen

“…Telomerase recruitment and activity are regulated by telomere-bound proteins that protect the chromosome ends. In this Perspective, the authors discuss recent…”
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TERT promoter mutations and telomeres during tumorigenesis by Lorbeer, Franziska K, Hockemeyer, Dirk

“…Telomerase regulation and telomere shortening act as a strong tumor suppressor mechanism in human somatic cells. Point mutations in the promoter of telomerase…”
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Genetically engineered human cortical spheroid models of tuberous sclerosis by Blair, John D., Hockemeyer, Dirk, Bateup, Helen S.

“…Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the TSC1 or TSC2 genes, whose protein products are negative…”
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Cancer-associated TERT promoter mutations abrogate telomerase silencing by Chiba, Kunitoshi, Johnson, Joshua Z, Vogan, Jacob M, Wagner, Tina, Boyle, John M, Hockemeyer, Dirk

“…Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in…”
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Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms by Liu, Tsung-Li, Upadhyayula, Srigokul, Milkie, Daniel E, Singh, Ved, Wang, Kai, Swinburne, Ian A, Mosaliganti, Kishore R, Collins, Zach M, Hiscock, Tom W, Shea, Jamien, Kohrman, Abraham Q, Medwig, Taylor N, Dambournet, Daphne, Forster, Ryan, Cunniff, Brian, Ruan, Yuan, Yashiro, Hanako, Scholpp, Steffen, Meyerowitz, Elliot M, Hockemeyer, Dirk, Drubin, David G, Martin, Benjamin L, Matus, David Q, Koyama, Minoru, Megason, Sean G, Kirchhausen, Tom, Betzig, Eric

“…True physiological imaging of subcellular dynamics requires studying cells within their parent organisms, where all the environmental cues that drive gene…”
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Highly efficient generation of isogenic pluripotent stem cell models using prime editing by Li, Hanqin, Busquets, Oriol, Verma, Yogendra, Syed, Khaja Mohieddin, Kutnowski, Nitzan, Pangilinan, Gabriella R, Gilbert, Luke A, Bateup, Helen S, Rio, Donald C, Hockemeyer, Dirk, Soldner, Frank

“…The recent development of prime editing (PE) genome engineering technologies has the potential to significantly simplify the generation of human pluripotent…”
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Widespread Translational Remodeling during Human Neuronal Differentiation by Blair, John D., Hockemeyer, Dirk, Doudna, Jennifer A., Bateup, Helen S., Floor, Stephen N.

“…Faithful cellular differentiation requires temporally precise activation of gene expression programs, which are coordinated at the transcriptional and…”
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats by Hargus, Gunnar, Cooper, oliver, Deleidi, Michela, Levy, Adam, Lee, Kristen, Marlow, Elizabeth, Yow, Alyssa, Soldner, Frank, Hockemeyer, Dirk, Hallett, Penelope J., Osbron, Teresia, Jaenisch, Rudolf, lsacson, Ole

“…Recent advances in deriving induced pluripotent stem (iPS) cells from patients offer new possibilities for biomedical research and clinical applications, as…”
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Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells by Guenther, Matthew G., Frampton, Garrett M., Soldner, Frank, Hockemeyer, Dirk, Mitalipova, Maya, Jaenisch, Rudolf, Young, Richard A.

“…Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells…”
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Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors by Soldner, Frank, Hockemeyer, Dirk, Beard, Caroline, Gao, Qing, Bell, George W., Cook, Elizabeth G., Hargus, Gunnar, Blak, Alexandra, Cooper, Oliver, Mitalipova, Maisam, Isacson, Ole, Jaenisch, Rudolf

“…Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for…”
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Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases by Amora, Ranier, Miller, Jeffrey C, Mitalipova, Maisam, Katibah, George E, Rebar, Edward J, Urnov, Fyodor D, Jaenisch, Rudolf, Gregory, Philip D, Boydston, Elizabeth A, Beard, Caroline, Hockemeyer, Dirk, Zeitler, Bryan, Meng, Xiangdong, Soldner, Frank, Gao, Qing, Zhang, Lei, DeKelver, Russell C

“…Hockemeyer et al . demonstrate targeted genetic modification of three genes in human embryonic stem cells and induced pluripotent stem cells using zinc-finger…”
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Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response by Kim, Won‐Tae, Hennick, Kelsey, Johnson, Joshua, Finnerty, Brendan, Choo, Seunga, Short, Sarah B, Drubin, Casey, Forster, Ryan, McMaster, Mary L, Hockemeyer, Dirk

“…Mutations in the shelterin protein POT1 are associated with chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, angiosarcoma, melanoma, and other cancers…”
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Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres by Hockemeyer, Dirk, Daniels, Jan-Peter, Takai, Hiroyuki, de Lange, Titia

“…Human telomeres are protected by shelterin, a complex that includes the POT1 single-stranded DNA binding protein. We found that mouse telomeres contain two…”
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A drug-inducible system for direct reprogramming of human somatic cells to pluripotency by Hockemeyer, Dirk, Soldner, Frank, Cook, Elizabeth G, Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf

“…Current approaches to reprogram human somatic cells to pluripotent iPSCs utilize viral transduction of different combinations of transcription factors. These…”
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Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution by Mudd, Austin B., Bredeson, Jessen V., Baum, Rachel, Hockemeyer, Dirk, Rokhsar, Daniel S.

“…Closely related muntjac deer show striking karyotype differences. Here we describe chromosome-scale genome assemblies for Chinese and Indian muntjacs,…”
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Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiation by Dambournet, Daphné, Sochacki, Kem A, Cheng, Aaron T, Akamatsu, Matthew, Taraska, Justin W, Hockemeyer, Dirk, Drubin, David G

“…We developed a general approach for investigation of how cellular processes become adapted for specific cell types during differentiation. Previous studies…”
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Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons by Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W., Orlando, David A., Lovén, Jakob, Kwok, Show-ming, Feldman, Danielle A., Bateup, Helen S., Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A., Vander Heiden, Matthew G., Sur, Mriganka, Young, Richard A., Jaenisch, Rudolf

“…Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an…”
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Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations by Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf

“…Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising…”
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Genome editing in human pluripotent stem cells using site-specific nucleases by Chiba, Kunitoshi, Hockemeyer, Dirk

“…Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) (Thomson, Science 282:1145-1147, 1998; Takahashi et al. Cell 131:861-872, 2007),…”
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TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation by Kabir, Shaheen, Hockemeyer, Dirk, de Lange, Titia

“…The conserved protein Rap1 functions at telomeres in fungi, protozoa, and vertebrates. Like yeast Rap1, human Rap1 has been implicated in telomere length…”
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