Search Results - "Hocini, Hakim"

Long-lasting severe immune dysfunction in Ebola virus disease survivors by Wiedemann, Aurélie, Foucat, Emile, Hocini, Hakim, Lefebvre, Cécile, Hejblum, Boris P., Durand, Mélany, Krüger, Miriam, Keita, Alpha Kabinet, Ayouba, Ahidjo, Mély, Stéphane, Fernandez, José-Carlos, Touré, Abdoulaye, Fourati, Slim, Lévy-Marchal, Claire, Raoul, Hervé, Delaporte, Eric, Koivogui, Lamine, Thiébaut, Rodolphe, Lacabaratz, Christine, Lévy, Yves

“…Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean…”
Get full text

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response by Rosenbaum, Pierre, Tchitchek, Nicolas, Joly, Candie, Rodriguez Pozo, André, Stimmer, Lev, Langlois, Sébastien, Hocini, Hakim, Gosse, Leslie, Pejoski, David, Cosma, Antonio, Beignon, Anne-Sophie, Dereuddre-Bosquet, Nathalie, Levy, Yves, Le Grand, Roger, Martinon, Frédéric

“…Vaccination is one of the most efficient public healthcare measures to fight infectious diseases. Nevertheless, the immune mechanisms induced by vaccination…”
Get full text

Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo by Blengio, Fabiola, Hocini, Hakim, Richert, Laura, Lefebvre, Cécile, Durand, Mélany, Hejblum, Boris, Tisserand, Pascaline, McLean, Chelsea, Luhn, Kerstin, Thiebaut, Rodolphe, Levy, Yves

“…Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination…”
Get full text

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death by Lévy, Yves, Wiedemann, Aurélie, Hejblum, Boris P., Durand, Mélany, Lefebvre, Cécile, Surénaud, Mathieu, Lacabaratz, Christine, Perreau, Matthieu, Foucat, Emile, Déchenaud, Marie, Tisserand, Pascaline, Blengio, Fabiola, Hivert, Benjamin, Gauthier, Marine, Cervantes-Gonzalez, Minerva, Bachelet, Delphine, Laouénan, Cédric, Bouadma, Lila, Timsit, Jean-François, Yazdanpanah, Yazdan, Pantaleo, Giuseppe, Hocini, Hakim, Thiébaut, Rodolphe

“…The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic,…”
Get full text

Secretory IgA induces tolerogenic dendritic cells through SIGNR1 dampening autoimmunity in mice by Diana, Julien, Moura, Ivan C, Vaugier, Céline, Gestin, Aurélie, Tissandie, Emilie, Beaudoin, Lucie, Corthésy, Blaise, Hocini, Hakim, Lehuen, Agnès, Monteiro, Renato C

“…IgA plays ambivalent roles in the immune system. The balance between inhibitory and activating responses relies on the multimerization status of IgA and…”
Get full text

Targeting human langerin promotes HIV-1 specific humoral immune responses by Kervevan, Jérôme, Bouteau, Aurélie, Lanza, Juliane S, Hammoudi, Adele, Zurawski, Sandra, Surenaud, Mathieu, Dieudonné, Lydie, Bonnet, Marion, Lefebvre, Cécile, Hocini, Hakim, Marlin, Romain, Guguin, Aurélie, Hersant, Barbara, Hermeziu, Oana, Menu, Elisabeth, Lacabaratz, Christine, Lelièvre, Jean-Daniel, Zurawski, Gerard, Godot, Véronique, Henri, Sandrine, Igyártó, Botond Z, Levy, Yves, Cardinaud, Sylvain

“…The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific…”
Get full text

High-Mobility Group Box 1-Signaling Inhibition With Glycyrrhizin Prevents Cerebral T-Cell Infiltration After Cardiac Arrest by Boissady, Emilie, Abi Zeid Daou, Yara, Faucher, Estelle, Kohlhauer, Matthias, Lidouren, Fanny, El Hedjaj, Cynthia, Chateau-Joubert, Sophie, Hocini, Hakim, Hue, Sophie, Ghaleh, Bijan, Tissier, Renaud

“…Background High-mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on…”
Get full text

P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART by Menkova-Garnier, Inna, Hocini, Hakim, Foucat, Emile, Tisserand, Pascaline, Bourdery, Laure, Delaugerre, Constance, Benne, Clarisse, Lévy, Yves, Lelièvre, Jean-Daniel

“…Peripheral CD4+ T-cell levels are not fully restored in a significant proportion of HIV+ individuals displaying long-term viral suppression on c-ART. These…”
Get full text

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation by Hovhannisyan, Yeranuhi, Li, Zhenlin, Callon, Domitille, Suspène, Rodolphe, Batoumeni, Vivien, Canette, Alexis, Blanc, Jocelyne, Hocini, Hakim, Lefebvre, Cécile, El-Jahrani, Nora, Kitsara, Maria, L'honoré, Aurore, Kordeli, Ekaterini, Fornes, Paul, Concordet, Jean-Paul, Tachdjian, Gérard, Rodriguez, Anne-Marie, Vartanian, Jean-Pierre, Béhin, Anthony, Wahbi, Karim, Joanne, Pierre, Agbulut, Onnik

“…Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in…”
Get full text

Ultrafast Hypothermia Selectively Mitigates the Early Humoral Response After Cardiac Arrest by Boissady, Emilie, Kohlhauer, Matthias, Lidouren, Fanny, Hocini, Hakim, Lefebvre, Cécile, Chateau-Jouber, Sophie, Mongardon, Nicolas, Deye, Nicolas, Cariou, Alain, Micheau, Philippe, Ghaleh, Bijan, Tissier, Renaud

“…Background Total liquid ventilation (TLV) has been shown to prevent neurological damage though ultrafast cooling in animal models of cardiac arrest. We…”
Get full text

Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry by Marlin, Romain, Nugeyre, Marie-Thérèse, Tchitchek, Nicolas, Parenti, Matteo, Hocini, Hakim, Benjelloun, Fahd, Cannou, Claude, Dereuddre-Bosquet, Nathalie, Levy, Yves, Barré-Sinoussi, Françoise, Scarlatti, Gabriella, Le Grand, Roger, Menu, Elisabeth

“…The female reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1. This site has been neglected in previous HIV-1 vaccine studies…”
Get full text

Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants by Cavarelli, Mariangela, Hua, Stéphane, Hantour, Naima, Tricot, Sabine, Tchitchek, Nicolas, Gommet, Céline, Hocini, Hakim, Chapon, Catherine, Dereuddre-Bosquet, Nathalie, Le Grand, Roger

“…Mucosal exposure to infected semen accounts for the majority of HIV-1 transmission events, with rectal intercourse being the route with the highest estimated…”
Get full text

Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals by Thiébaut, Rodolphe, Hejblum, Boris P, Hocini, Hakim, Bonnabau, Henri, Skinner, Jason, Montes, Monica, Lacabaratz, Christine, Richert, Laura, Palucka, Karolina, Banchereau, Jacques, Lévy, Yves

“…The goal of HIV therapeutic vaccination is to induce HIV-specific immune response able to control HIV replication. We previously reported that vaccination with…”
Get full text

CD73+ CD127high Long-Term Memory CD4 T Cells Are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection by Seddiki, Nabila, Zaunders, John, Phetsouphanh, Chan, Brezar, Vedran, Xu, Yin, McGuire, Helen M., Bailey, Michelle, McBride, Kristin, Hey-Cunningham, Will, Munier, Cynthia Mee Ling, Cook, Laura, Kent, Stephen, Lloyd, Andrew, Cameron, Barbara, Fazekas de St Groth, Barbara, Koelsch, Kersten, Danta, Mark, Hocini, Hakim, Levy, Yves, Kelleher, Anthony D.

“…HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall antigens. We report here that…”
Get full text

Stepwise release of biologically active HMGB1 during HSV-2 infection by Borde, Chloé, Barnay-Verdier, Stéphanie, Gaillard, Claire, Hocini, Hakim, Maréchal, Vincent, Gozlan, Joël

“…High mobility group box 1 protein (HMGB1) is a major endogenous danger signal that triggers inflammation and immunity during septic and aseptic stresses. HMGB1…”
Get full text

Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study by Bodez, Diane, Hocini, Hakim, Tchitchek, Nicolas, Tisserand, Pascaline, Benhaiem, Nicole, Barau, Caroline, Kharoubi, Mounira, Guellich, Aziz, Guendouz, Soulef, Radu, Costin, Couetil, Jean-Paul, Ghaleh, Bijan, Dubois-Randé, Jean-Luc, Teiger, Emmanuel, Hittinger, Luc, Levy, Yves, Damy, Thibaud

“…Serial invasive endomyocardial biopsies (EMB) remain the gold standard for acute cellular rejection (ACR) diagnosis. However histological grading has several…”
Get full text

Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine by Rosenbaum, Pierre, Tchitchek, Nicolas, Joly, Candie, Stimmer, Lev, Hocini, Hakim, Dereuddre-Bosquet, Nathalie, Beignon, Anne-Sophie, Chapon, Catherine, Levy, Yves, Le Grand, Roger, Martinon, Frédéric

“…New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of…”
Get full text

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane by Py, Bénédicte, Basmaciogullari, Stéphane, Bouchet, Jérôme, Zarka, Marion, Moura, Ivan C, Benhamou, Marc, Monteiro, Renato C, Hocini, Hakim, Madrid, Ricardo, Benichou, Serge

“…Secretory leukocyte protease inhibitor (SLPI) is secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal…”
Get full text

Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae by Marlin, Romain, Nugeyre, Marie-Thérèse, Tchitchek, Nicolas, Parenti, Matteo, Lefebvre, Cécile, Hocini, Hakim, Benjelloun, Fahd, Cannou, Claude, Nozza, Silvia, Dereuddre-Bosquet, Nathalie, Levy, Yves, Barré-Sinoussi, Françoise, Scarlatti, Gabriella, Le Grand, Roger, Menu, Elisabeth

“…HIV-1 sexual transmission occurs mainly via mucosal semen exposures. In the female reproductive tract (FRT), seminal plasma (SP) induces physiological…”
Get full text

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death by Lévy, Yves, Wiedemann, Aurélie, Hejblum, Boris P., Durand, Mélany, Lefebvre, Cécile, Surénaud, Mathieu, Lacabaratz, Christine, Perreau, Matthieu, Foucat, Emile, Déchenaud, Marie, Tisserand, Pascaline, Blengio, Fabiola, Hivert, Benjamin, Gauthier, Marine, Cervantes-Gonzalez, Minerva, Bachelet, Delphine, Laouénan, Cédric, Bouadma, Lila, Timsit, Jean-François, Yazdanpanah, Yazdan, Pantaleo, Giuseppe, Hocini, Hakim, Thiébaut, Rodolphe

Get full text