Search Results - "Hochwald, N"

The role of FAK in tumor metabolism and therapy by JIANLIANG ZHANG, HOCHWALD, Steven N

“…Focal adhesion kinase (FAK) plays a vital role in tumor cell proliferation, survival and migration. Altered metabolic pathways fuel rapid tumor growth by…”
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Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis by Zhang, J, Gao, Q, Zhou, Y, Dier, U, Hempel, N, Hochwald, S N

“…Cancer cells often gains a growth advantage by taking up glucose at a high rate and undergoing aerobic glycolysis through intrinsic cellular factors that…”
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Current Understanding of the Molecular Biology of Pancreatic Neuroendocrine Tumors by JIANLIANG ZHANG, FRANCOIS, Rony, IYER, Renuka, SESHADRI, Mukund, ZAJAC-KAYE, Maria, HOCHWALD, Steven N

“…Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly neoplasms. A recent increased understanding of their molecular biology has…”
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Gastrointestinal stromal tumors (GISTs) at uncommon locations: A large population based analysis by Kukar, Moshim, Kapil, Aditi, Papenfuss, Wesley, Groman, Adrienne, Grobmyer, Stephen R., Hochwald, Steven N.

“…Introduction Sparse information is available about GISTs in uncommon locations. Our large database analysis aims to determine the characteristics of GISTs in…”
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Pathologic Complete Response Is an Independent Predictor of Improved Survival Following Neoadjuvant Chemoradiation for Esophageal Adenocarcinoma by Alnaji, Raed M., Du, William, Gabriel, Emmanuel, Singla, Smit, Attwood, Kristopher, Nava, Hector, Malhotra, Usha, Hochwald, Steven N., Kukar, Moshim

“…Introduction Reports of improved survival in patients with pathologic complete response (pCR) to neoadjuvant therapy for esophageal and gastroesophageal…”
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Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors by François, Rony A, Maeng, Kyungah, Nawab, Akbar, Kaye, Frederic J, Hochwald, Steven N, Zajac-Kaye, Maria

“…Focal adhesion kinase (FAK) mediates survival of normal pancreatic islets through activation of AKT. Upon malignant transformation of islet cells into…”
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Ablative Therapies for Locally Advanced Pancreatic Cancer by Shah, Rupen, Ostapoff, Katherine T, Kuvshinoff, Boris, Hochwald, Steven N

“…The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without…”
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Decreasing morbidity and mortality in 100 consecutive minimally invasive esophagectomies by Ben-David, Kfir, Sarosi, George A., Cendan, Juan C., Howard, Drew, Rossidis, Georgios, Hochwald, Steven N.

“…Introduction Esophagectomy is a complex invasive procedure that requires exploration of multiple body cavities for removal and subsequent restoration of…”
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Novel Pancreaticojejunostomy with a Low Rate of Anastomotic Failure-Related Complications by Grobmyer, Stephen R., MD, FACS, Kooby, David, MD, FACS, Blumgart, Leslie H., MD, FACS, Hochwald, Steven N., MD, FACS

“…Background Pancreatic anastomotic failure has traditionally been a source of significant morbidity and potential mortality after pancreaticoduodenectomy. Both…”
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Esophageal cancer-the five year survivors by Kim, Tad, Grobmyer, Stephen R, Smith, Reshelle, Ben-David, Kfir, Ang, Darwin, Vogel, Stephen B, Hochwald, Steven N

“…Background Esophageal cancer in the United States carries a poor prognosis with overall 5 year survival rate of approximately 10%. Due to this dismal outcome,…”
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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer by Hochwald, Steven N., Nyberg, Carl, Zheng, Min, Zheng, Donghang, Wood, Cheng, Massoll, Nicole A., Magis, Andrew, Ostrov, David, Cance, William G., Golubovskaya, Vita M.

“…Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is overexpressed in many types of tumors, including pancreatic cancer, and plays an important…”
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Determining Prognosis in Patients With Pancreatic Endocrine Neoplasms: Can the WHO Classification System Be Simplified? by FERRONE, Cristina R, TANG, Laura H, TOMLINSON, James, GONEN, Mithat, HOCHWALD, Steven N, BRENNAN, Murray F, KLIMSTRA, David S, ALLEN, Peter J

“…The WHO classification for well-differentiated pancreatic endocrine neoplasms (PENs) incorporates both stage and grade. This study compares the prognostic…”
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Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations by Grobmyer, Stephen R., Reith, John D., Shahlaee, Amir, Bush, Charles H., Hochwald, Steven N.

“…Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare tumors that often occur in patients with neurofibromatosis 1. Surgical resection represents the…”
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Prognostic Factors in Pancreatic Endocrine Neoplasms: An Analysis of 136 Cases With a Proposal for Low-Grade and Intermediate-Grade Groups by HOCHWALD, Steven N, SUI ZEE, CONLON, Kevin C, COLLEONI, Roberto, LOUIE, Otway, BRENNAN, Murray F, KLIMSTRA, David S

“…In some organs (eg, the lung), endocrine tumors are classified on the basis of mitotic rate and necrosis. The purpose of this study was to evaluate prognostic…”
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Altered LKB1 CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion by Gu, Y, Lin, S, Li, J-L, Nakagawa, H, Chen, Z, Jin, B, Tian, L, Ucar, D A, Shen, H, Lu, J, Hochwald, S N, Kaye, F J, Wu, L

“…LKB1 is a tumor susceptibility gene for the Peutz–Jeghers cancer syndrome and is a target for mutational inactivation in sporadic human malignancies. LKB1…”
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Prospective Multicenter Phase II Trial of Systemic ADH-1 in Combination With Melphalan via Isolated Limb Infusion in Patients With Advanced Extremity Melanoma by BEASLEY, Georgia M, RIBOH, Jonathan C, AUGUSTINE, Christina K, ZAGER, Jonathan S, HOCHWALD, Steven N, GROBMYER, Stephen R, PETERSON, Bercedis, ROYAL, Richard, ROSS, Merrick I, TYLER, Douglas S

“…Isolated limb infusion (ILI) with melphalan (M-ILI) dosing corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit…”
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Shave Biopsy Is a Safe and Accurate Method for the Initial Evaluation of Melanoma by Zager, Jonathan S., MD, FACS, Hochwald, Steven N., MD, FACS, Marzban, Suroosh S., BS, Francois, Rony, BS, Law, Kimberly M., BS, Davis, Ashley H., BS, Messina, Jane L., MD, Vincek, Vladimir, MD, PhD, Mitchell, Christina, MD, Church, Ann, MD, Copeland, Edward M., MD, FACS, Sondak, Vernon K., MD, FACS, Grobmyer, Stephen R., MD, FACS

“…Background Shave biopsy of cutaneous lesions is simple, efficient, and commonly used clinically. However, this technique has been criticized for its potential…”
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FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells by Liu, Weiguo, Bloom, David A., Cance, William G., Kurenova, Elena V., Golubovskaya, Vita M., Hochwald, Steven N.

“…Pancreatic cancer is a lethal disease accounting for the fourth leading cause of cancer death in USA. Focal adhesion kinase (FAK) and the insulin-like growth…”
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Utilization of minimally invasive breast biopsy for the evaluation of suspicious breast lesions by Gutwein, Luke G., M.D, Ang, Darwin N., M.D, Liu, Huazhi, Marshall, Julia K., M.D, Hochwald, Steven N., M.D, Copeland, Edward M., M.D, Grobmyer, Stephen R., M.D

“…Abstract Background Percutaneous needle biopsy, also known as minimally invasive breast biopsy (MIBB), has become the gold standard for the initial assessment…”
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Retroperitoneal soft tissue sarcoma by Mendenhall, William M., Zlotecki, Robert A., Hochwald, Steven N., Hemming, Alan W., Grobmyer, Stephen R., Cance, William G.

“…The objective of the current study was to define the optimal treatment for patients with retroperitoneal soft tissue sarcomas (RPS). The authors conducted a…”
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