Search Results - "Hochstrasser, L."

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference by Hochstrasser, Megan L., Taylor, David W., Bhata, Prashant, Guegler, Chantal K., Sternberg, Samuel H., Nogales, Eva, Doudna, Jennifer A.

“…In bacteria, the clustered regularly interspaced short palindromic repeats (CRISPR)–associated (Cas) DNA-targeting complex Cascade (CRISPR-associated complex…”
Get full text

Long-term reduction of seclusion and forced medication on a hospital-wide level: Implementation of an open-door policy over 6 years by Hochstrasser, L., Fröhlich, D., Schneeberger, A.R., Borgwardt, S., Lang, U.E., Stieglitz, R.-D., Huber, C.G.

“…Psychiatric inpatient treatment is increasingly performed in settings with locked doors. However, locked wards have well-known disadvantages and are ethically…”
Get full text

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing by Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R

“…The proteostasis network has evolved to support protein folding under normal conditions and to expand this capacity in response to proteotoxic stresses…”
Get full text

Association of Positive and Negative Syndrome Scale short forms with global functioning and quality of life by Hochstrasser, L., Borgwardt, S., Lambert, M., Schimmelmann, B. G., Lang, U. E., Stieglitz, R.-D., Huber, C. G.

Get full text

Cutting it close: CRISPR-associated endoribonuclease structure and function by Hochstrasser, Megan L., Doudna, Jennifer A.

“…•We define the key structural features shared by CRISPR-associated endoRNases.•We explain how Cas6 enzymes recognize RNA with high affinity and specificity.•We…”
Get full text

Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus by Ehrenberg, Alexander J, Moehle, Erica A, Brook, Cara E, Doudna Cate, Andrew H, Witkowsky, Lea B, Sachdeva, Rohan, Hirsh, Ariana, Barry, Kerrie, Hamilton, Jennifer R, Lin-Shiao, Enrique, McDevitt, Shana, Valentin-Alvarado, Luis, Letourneau, Kaitlyn N, Hunter, Lauren, Keller, Amanda, Pestal, Kathleen, Frankino, Phillip A, Murley, Andrew, Nandakumar, Divya, Stahl, Elizabeth C, Tsuchida, Connor A, Gildea, Holly K, Murdock, Andrew G, Hochstrasser, Megan L, O'Brien, Elizabeth, Ciling, Alison, Tsitsiklis, Alexandra, Worden, Kurtresha, Dugast-Darzacq, Claire, Hays, Stephanie G, Barber, Colin C, McGarrigle, Riley, Lam, Emily K, Ensminger, David C, Bardet, Lucie, Sherry, Carolyn, Harte, Anna, Nicolette, Guy, Giannikopoulos, Petros, Hockemeyer, Dirk, Petersen, Maya, Urnov, Fyodor D, Ringeisen, Bradley R, Boots, Mike, Doudna, Jennifer A

“…Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to SARS-CoV-2 outbreak prevention on college and university campuses…”
Get full text

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade by Hochstrasser, Megan L., Taylor, David W., Kornfeld, Jack E., Nogales, Eva, Doudna, Jennifer A.

“…Bacteria employ surveillance complexes guided by CRISPR (clustered, regularly interspaced, short palindromic repeats) RNAs (crRNAs) to target foreign nucleic…”
Get full text

Clinical applications of CRISPR‐based genome editing and diagnostics by Foss, Dana V., Hochstrasser, Megan L., Wilson, Ross C.

“…Clustered regularly interspaced short palindromic repeats (CRISPR)‐driven genome editing has rapidly transformed preclinical biomedical research by eliminating…”
Get full text

Thermal preference of Culicoides biting midges in laboratory and semi-field settings by Hochstrasser, Alec L., Mathis, Alexander, Verhulst, Niels O.

“…Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are hematophagous insects, and some species can transmit a plethora of pathogens, e.g.,…”
Get full text

Monitoring SARS-CoV-2 incidence and seroconversion among university students and employees: a longitudinal cohort study in California, June–August 2020 by Hunter, Lauren A, Wyman, Stacia, Packel, Laura J, Facente, Shelley N, Li, Yi, Harte, Anna, Nicolette, Guy, Di Germanio, Clara, Busch, Michael P, Reingold, Arthur L, Petersen, Maya L, Urnov, Fyodor, McDevitt, Shana, Hirsch, Ariana, Ehrenberg, Alexander, Doudna, Jennifer A, Amen, M, Barry, Kerrie W, Boyle, John M, Brook, Cara E, Choo, Seunga, Cornmesser, LT, Dilworth, David J, Fedrigo, Indro, Friedline, Skyler E, Graham, Thomas G W, Green, Ralph, Hamilton, Jennifer R, Hochstrasser, Megan L, Hockemeyer, Dirk, Krishnappa, Netravathi, Lari, Azra, Li, Hanqin, Lin-Shiao, Enrique, Lu, Tianlin, Lyons, Elijah F, Mark, Kevin G, Martell, Lisa Argento, Martins, A Raquel O, Mitchell, Patrick S, Moehle, Erica A, Naca, Christine, Nandakumar, Divya, O’Brien, Elizabeth, Pappas, Derek J, Pestal, Kathleen, Quach, Diana L, Rubin, Benjamin E, Sachdeva, Rohan, Stahl, Elizabeth C, Syed, Abdullah Muhammad, Tan, I-Li, Tollner, Amy L, Tsuchida, Connor A, Kimberly Tsui, C, Turkalo, Timothy K, Bryan Warf, M, Whitney, Oscar N, Witkowsky, Lea B

“…ObjectivesTo identify incident SARS-CoV-2 infections and inform effective mitigation strategies in university settings, we piloted an integrated symptom and…”
Get full text

Blueprint for a pop-up SARS-CoV-2 testing lab by Amen, Alexandra M, Barry, Kerrie W, Boyle, John M, Brook, Cara E, Choo Seunga, Cornmesser, L T, Dilworth, David J, Doudna, Jennifer A, Ehrenberg, Alexander J, Fedrigo Indro, Friedline, Skyler E, Graham Thomas G W, Green, Ralph, Hamilton, Jennifer R, Hirsh Ariana, Hochstrasser, Megan L, Hockemeyer Dirk, Krishnappa Netravathi, Lari Azra, Li, Hanqin, Lin-Shiao, Enrique, Lu Tianlin, Lyons, Elijah F, Mark, Kevin G, Martell Lisa Argento, Raquel O, Martins A, McDevitt, Shana L, Mitchell, Patrick S, Moehle, Erica A, Naca Christine, Nandakumar Divya, O’Brien Elizabeth, Pappas, Derek J, Pestal, Kathleen, Quach, Diana L, Rubin, Benjamin E, Sachdeva Rohan, Stahl, Elizabeth C, Syed Abdullah Muhammad, I-Li, Tan, Tollner, Amy L, Tsuchida, Connor A, Kimberly, Tsui C, Turkalo, Timothy K, Urnov Fyodor D, Bryan, Warf M, Whitney, Oscar N, Witkowsky, Lea B

Get full text

Correction: Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing by Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R

“…Klaips CL, Hochstrasser ML, Langlois CR, Serio TR. 2014. Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing. eLife…”
Get full text

CRISPR meets caspase by Hochstrasser, Megan L., Nuñez, James K.

“…Diverse CRISPR–Cas systems protect prokaryotes against invasive genetic elements like phages. A new study finds that evolution has fused a multi-subunit CRISPR…”
Get full text

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms by Farboud, Behnom, Jarvis, Erin, Roth, Theodore L, Shin, Jiyung, Corn, Jacob E, Marson, Alexander, Meyer, Barbara J, Patel, Nipam H, Hochstrasser, Megan L

“…Site-specific eukaryotic genome editing with CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems has quickly…”
Get full text

Severe neonatal blood loss due to umbilical cord rupture in an underwater birth by Kalf, K, Hochstrasser, L, Lapaire, O, Hegi, L, Benzing, J, Hösli, I

“…We present the case of an intrapartum umbilical cord rupture in an underwater birth with severe neonatal blood loss. A healthy 25-year-old gravida I with an…”
Get more information

A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor by Petti, Lisa M., Talbert-Slagle, Kristina, Hochstrasser, Megan L., DiMaio, Daniel

“…Receptors for PDGF play an important role in cell proliferation and migration and have been implicated in certain cancers. The 44-amino acid E5 protein of…”
Get full text

Continuing Medical Education Program in Transfusion

Get full text

Family Planning and Fertility in Southern Appalachia: A Community Study by HOCHSTRASSER, DONALD L., GAIROLA, GERRY A.

“…Fertility and fertility regulation remain key issues in dealing with global problems of population control and ecological sustainability in modern society. The…”
Get full text

Modern contraceptive practice in rural Appalachia by Gairola, G A, Hochstrasser, D L, Garkovich, L E

“…This paper examines contraceptive practice in a traditionally high fertility and economically disadvantaged rural county of central Appalachia. A key…”
Get full text

Sources and uses of environmental, land use and development information by Hochstrasser, Scott L

“…The major purpose of the EuroInfo Conference is to discuss information resource management. Members of the European Commission and Polish business and industry…”
Get full text