Search Results - "Hochmair, Janine"

Initiation and modulation of Tau protein phase separation by the drug suramin by Prince, Prabhu Rajaiah, Hochmair, Janine, Brognaro, Hévila, Gevorgyan, Susanna, Franck, Maximilian, Schubert, Robin, Lorenzen, Kristina, Yazici, Selin, Mandelkow, Eckhard, Wegmann, Susanne, Betzel, Christian

“…Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated Tau is the main component of neurofibrillary tangles observed in…”
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Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate by Rosam, Mathias, Krader, Daniela, Nickels, Christina, Hochmair, Janine, Back, Katrin C., Agam, Ganesh, Barth, Anders, Zeymer, Cathleen, Hendrix, Jelle, Schneider, Markus, Antes, Iris, Reinstein, Jochen, Lamb, Don C., Buchner, Johannes

“…BiP is the endoplasmic member of the Hsp70 family. BiP is regulated by several co-chaperones including the nucleotide-exchange factor (NEF) Bap (Sil1 in…”
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Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98 by Diez, Lisa, Kapinos, Larisa E, Hochmair, Janine, Huebschmann, Sabrina, Dominguez-Baquero, Alvaro, Vogt, Amelie, Rankovic, Marija, Zweckstetter, Markus, Lim, Roderick Y H, Wegmann, Susanne

“…Tau is a neuronal protein that stabilizes axonal microtubules (MTs) in the central nervous system. In Alzheimer's disease (AD) and other tauopathies,…”
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Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates by Hochmair, Janine, Exner, Christian, Franck, Maximilian, Dominguez‐Baquero, Alvaro, Diez, Lisa, Brognaro, Hévila, Kraushar, Matthew L, Mielke, Thorsten, Radbruch, Helena, Kaniyappan, Senthilvelrajan, Falke, Sven, Mandelkow, Eckhard, Betzel, Christian, Wegmann, Susanne

“…Biomolecular condensation of the neuronal microtubule‐associated protein Tau (MAPT) can be induced by coacervation with polyanions like RNA, or by molecular…”
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