Search Results - "Hochlowski, Jill"

Ultrasound-assisted click chemistry in continuous flow by Tu, Noah P., Hochlowski, Jill E., Djuric, Stevan W.

“…We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication…”
Get full text

An Automated Synthesis–Purification–Sample-Management Platform for the Accelerated Generation of Pharmaceutical Candidates by Sutherland, J. David, Tu, Noah P., Nemcek, Thomas A., Searle, Philip A., Hochlowski, Jill E., Djuric, Stevan W., Pan, Jeffrey Y.

“…A flexible and integrated flow-chemistry–synthesis–purification compound-generation and sample-management platform has been developed to accelerate the…”
Get full text

Purification of high-throughput organic synthesis libraries by counter-current chromatography by Wagenaar, Frank L., Hochlowski, Jill E., Pan, Jeffrey Y., Tu, Noah P., Searle, Philip A.

“…Experiments were performed to evaluate whether counter-current chromatography (CCC) could function as an alternative purification method to reversed-phase…”
Get full text

An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery by Hochlowski, Jill E., Searle, Philip A., Tu, Noah P., Pan, Jeffrey Y., Spanton, Stephen G., Djuric, Stevan W.

“…We report herein a high-throughput integrated synthesis—purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that…”
Get full text

Purification of drugs from biological fluids by counter-current chromatography by Hochlowski, Jill E., Pan, Jeffrey Y., Searle, Philip A., Buck, Wayne R., Spanton, Stephen G.

“…Experiments were performed to demonstrate the potential of counter-current chromatography (CCC) for the isolation of drugs and their metabolites from…”
Get full text

5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners by Hochlowski, J E, Mullally, M M, Spanton, S G, Whittern, D N, Hill, P, McAlpine, J B

“…A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the…”
Get more information

Production of brominated tiacumicin derivatives by Hochlowski, J E, Jackson, M, Rasmussen, R R, Buko, A M, Clement, J J, Whittern, D N, McAlpine, J B

“…Several novel tiacumicin derivatives containing bromine have been produced by the addition of inorganic bromine to the fermentation both of Dactylosporangium…”
Get more information

Macquarimicins, microbial metabolites from Micromonospora. II. Isolation and structural elucidation by Hochlowski, J E, Mullally, M M, Henry, R, Whittern, D M, McAlpine, J B

“…A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end…”
Get more information

Citrinin hydrate and radicinin: human rhinovirus 3C-protease inhibitors discovered in a target-directed microbial screen by Kadam, S, Poddig, J, Humphrey, P, Karwowski, J, Jackson, M, Tennent, S, Fung, L, Hochlowski, J, Rasmussen, R, McAlpine, J

Get more information

Metabolites of four nudibranchs of the genus Hypselodoris by Hochlowski, Jill E, Walker, Roger P, Ireland, Chris, Faulkner, D. John

Get full text

Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. II. Isolation and elucidation of structures by Hochlowski, J E, Whittern, D N, Hill, P, McAlpine, J B

“…Two novel antifungal antibiotics, named dorrigocin A and B have been isolated from the fermentation broth and mycelium of Streptomyces platensis subsp…”
Get more information

Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation by Hochlowski, J E, Whittern, D N, Buko, A, Alder, L, McAlpine, J B

“…Two novel antifungal compounds of the papulacandin class, named fusacandins A and B, have been isolated from Fusarium sambucinum. Each compound contains two…”
Get more information

Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants by Burres, N S, Premachandran, U, Hoselton, S, Cwik, D, Hochlowski, J E, Ye, Q, Sunga, G N, Karwowski, J P, Jackson, M, Whittern, D N

“…Determination of the mechanism of action of FK506 and cyclosporin A has yielded new molecular targets involved in signal transduction during T cell activation…”
Get more information

The denticulatins, two polypropionate metabolites from the pulmonate Siphonaria denticulata by Hochlowski, Jill E, Faulkner, D. John, Matsumoto, Gayle K, Clardy, Jon

Get full text

Comparison of Preparative HPLC/MS and Preparative SFC Techniques for the High-Throughput Purification of Compound Libraries by Searle, Philip A, Glass, Keithney A, Hochlowski, Jill E

“…A diverse set of 16 high-throughput organic synthesis libraries, consisting of 48 samples per library, has been purified by both preparative supercritical…”
Get full text

Norrisolide, a novel diterpene from the dorid nudibranch Chromodoris norrisi by Hochlowski, Jill E, Faulkner, D. John, Matsumoto, Gayle K, Clardy, Jon

“…The dorid nudibranch C. norrisi contains an unusual rearranged diterpene, norrisolide. The structure of norrisolide was determined by X-ray diffraction…”
Get full text

Current Application of Mass Spectrometry to Combinatorial Chemistry by Cheng, Xueheng, Hochlowski, Jill

“…During the past decade, combinatorial chemistry has become an integral component of nearly all drug discovery efforts, and mass spectrometry has played a key…”
Get full text

Studies on repository compound stability in DMSO under various conditions by Cheng, Xueheng, Hochlowski, Jill, Tang, Hua, Hepp, Darlene, Beckner, Carl, Kantor, Stan, Schmitt, Robert

“…The chemical stability of repository compounds is affected by various environmental conditions during long-term storage. Studies were carried out to evaluate…”
Get more information

Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures by Hochlowski, J E, Mullally, M M, Brill, G M, Whittern, D N, Buko, A M, Hill, P, McAlpine, J B

“…A novel complex of antifungal and immunosuppressant compounds has been isolated from the fermentation broth and mycelia of two strains of Streptomyces…”
Get more information

Aselacins, novel compounds that inhibit binding of endothelin to its receptor. II. Isolation and elucidation of structures by Hochlowski, J E, Hill, P, Whittern, D N, Scherr, M H, Rasmussen, R R, Dorwin, S A, McAlpine, J B

“…Three novel compounds, named the aselacins, which inhibit the binding of endothelin to its receptor have been isolated from two related Acremonium species of…”
Get more information