Search Results - "Hochberg, A A"

Reconstructing Ancient Proteins to Understand the Causes of Structure and Function by Hochberg, Georg K. A, Thornton, Joseph W

“…A central goal in biochemistry is to explain the causes of protein sequence, structure, and function. Mainstream approaches seek to rationalize sequence and…”
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Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles by Marty, Michael T, Baldwin, Andrew J, Marklund, Erik G, Hochberg, Georg K. A, Benesch, Justin L. P, Robinson, Carol V

“…Interpretation of mass spectra is challenging because they report a ratio of two physical quantities, mass and charge, which may each have multiple components…”
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Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus by Addison, Holly, Glatter, Timo, K A Hochberg, Georg, Rebelein, Johannes G

“…Nitrogenases are the only enzymes able to fix gaseous nitrogen into bioavailable ammonia and hence are essential for sustaining life. Catalysis by nitrogenases…”
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Simple mechanisms for the evolution of protein complexity by Pillai, Arvind S., Hochberg, Georg K.A., Thornton, Joseph W.

“…Proteins are tiny models of biological complexity: specific interactions among their many amino acids cause proteins to fold into elaborate structures,…”
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Structural basis for lipid and copper regulation of the ABC transporter MsbA by Lyu, Jixing, Liu, Chang, Zhang, Tianqi, Schrecke, Samantha, Elam, Nicklaus P., Packianathan, Charles, Hochberg, Georg K. A., Russell, David, Zhao, Minglei, Laganowsky, Arthur

“…A critical step in lipopolysaccharide (LPS) biogenesis involves flipping lipooligosaccharide, an LPS precursor, from the cytoplasmic to the periplasmic leaflet…”
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An ultra-stable gold-coordinated protein cage displaying reversible assembly by Malay, Ali D., Miyazaki, Naoyuki, Biela, Artur, Chakraborti, Soumyananda, Majsterkiewicz, Karolina, Stupka, Izabela, Kaplan, Craig S., Kowalczyk, Agnieszka, Piette, Bernard M. A. G., Hochberg, Georg K. A., Wu, Di, Wrobel, Tomasz P., Fineberg, Adam, Kushwah, Manish S., Kelemen, Mitja, Vavpetič, Primož, Pelicon, Primož, Kukura, Philipp, Benesch, Justin L. P., Iwasaki, Kenji, Heddle, Jonathan G.

“…Symmetrical protein cages have evolved to fulfil diverse roles in nature, including compartmentalization and cargo delivery 1 , and have inspired synthetic…”
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Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus by Carreira, Luís António Menezes, Szadkowski, Dobromir, Lometto, Stefano, Hochberg, Georg. K. A., Søgaard-Andersen, Lotte

“…During cell migration, front-rear polarity is spatiotemporally regulated; however, the underlying design of regulatory interactions varies. In rod-shaped…”
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The emergence of Sox and POU transcription factors predates the origins of animal stem cells by Gao, Ya, Tan, Daisylyn Senna, Girbig, Mathias, Hu, Haoqing, Zhou, Xiaomin, Xie, Qianwen, Yeung, Shi Wing, Lee, Kin Shing, Ho, Sik Yin, Cojocaru, Vlad, Yan, Jian, Hochberg, Georg K. A., de Mendoza, Alex, Jauch, Ralf

“…Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are associated with stemness and were believed to be animal…”
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The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity by Hochberg, Georg K. A., Ecroyd, Heath, Liu, Cong, Cox, Dezerae, Cascio, Duilio, Sawaya, Michael R., Collier, Miranda P., Stroud, James, Carver, John A., Baldwin, Andrew J., Robinson, Carol V., Eisenberg, David S., Benesch, Justin L. P., Laganowsky, Arthur

“…Mammalian small heat-shock proteins (sHSPs) are molecular chaperones that form polydisperse and dynamic complexes with target proteins, serving as a first line…”
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The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression by Jakob, Sara, Steinchen, Wieland, Hanßmann, Juri, Rosum, Julia, Langenfeld, Katja, Osorio-Valeriano, Manuel, Steube, Niklas, Giammarinaro, Pietro I., Hochberg, Georg K. A., Glatter, Timo, Bange, Gert, Diepold, Andreas, Thanbichler, Martin

“…The transcriptional antisilencer VirB acts as a master regulator of virulence gene expression in the human pathogen Shigella flexneri . It binds DNA sequences…”
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Evolution of protein specificity: insights from ancestral protein reconstruction by Siddiq, Mohammad A, Hochberg, Georg KA, Thornton, Joseph W

“…[Display omitted] •Ancestral protein reconstruction has revealed how molecular interactions evolved.•Not all paralogs with distinct functions evolved from…”
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EP32.02: Is maximalisation of the ovum pick‐up procedure beneficial for the outcome of assisted reproductive technology cycles? by Danieli‐Gruber, S., Sapir, O., Netanely, D., Hochberg, A., Ben‐Haroush, A., Wertheimer, A., Altman, E., Domniz, N., Shufaro, Y.

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Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase" by Park, Yeonwoo, Patton, Jaeda E J, Hochberg, Georg K A, Thornton, Joseph W

“…Hadzipasic (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused…”
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Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer by Hanna, N, Ohana, P, Konikoff, F M, Leichtmann, G, Hubert, A, Appelbaum, L, Kopelman, Y, Czerniak, A, Hochberg, A

“…BC-819 is a DNA plasmid that was developed to target the expression of diphtheria-toxin gene under the control of H19 regulatory sequences. BC-819 has the…”
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OC02.06: Fetal and neonatal brain injury following laser ablation for TTTS as detected by pre‐ and postnatal brain imaging by Hochberg, A., Silber, R., Katorza, E., Avnet, H., Lipitz, S., Weisz, B., Yinon, Y.

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Paracetamol treatment of patent ductus arteriosus in preterm infants by Nadir, E, Kassem, E, Foldi, S, Hochberg, A, Feldman, M

“…Objective: To determine the effectiveness of paracetamol in closing patent ductus arteriosus (PDA) in preterm infants of our population. Study Design: Infants…”
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Time-to-Signal Comparison for Drug Safety Data-Mining Algorithms vs. Traditional Signaling Criteria by Hochberg, AM, Hauben, M

“…Data mining may improve identification of signals, but its incremental utility is in question. The objective of this study was to compare associations…”
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ATPase Activity of Bacillus subtilis RecA Affects the Dynamic Formation of RecA Filaments at DNA Double Strand Breaks by Hernández-Tamayo, Rogelio, Steube, Niklas, Heimerl, Thomas, Hochberg, Georg K A, Graumann, Peter L

“…RecA plays a central role in DNA repair and is a main actor involved in homologous recombination (HR). , RecA forms filamentous structures termed "threads,"…”
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Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems by Moldenhauer, Marcus, Tseng, Hsueh-Wei, Kraskov, Anastasia, Tavraz, Neslihan N, Yaroshevich, Igor A, Hildebrandt, Peter, Sluchanko, Nikolai N, Hochberg, Georg A, Essen, Lars-Oliver, Budisa, Nediljko, Korf, Lukas, Maksimov, Eugene G, Friedrich, Thomas

“…Dissecting the intricate networks of covalent and non-covalent interactions that stabilize complex protein structures is notoriously difficult and requires…”
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A hydrophobic ratchet entrenches molecular complexes by Hochberg, Georg K. A., Liu, Yang, Marklund, Erik G., Metzger, Brian P. H., Laganowsky, Arthur, Thornton, Joseph W.

“…Most proteins assemble into multisubunit complexes 1 . The persistence of these complexes across evolutionary time is usually explained as the result of…”
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