Applications of focused ultrasound-mediated blood-brain barrier opening

The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies. In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agen...

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Bibliographic Details
Published in:	Advanced drug delivery reviews Vol. 191; p. 114583
Main Authors:	Gorick, Catherine M, Breza, Victoria R, Nowak, Katherine M, Cheng, Vinton W T, Fisher, Delaney G, Debski, Anna C, Hoch, Matthew R, Demir, Zehra E F, Tran, Nghi M, Schwartz, Mark R, Sheybani, Natasha D, Price, Richard J
Format:	Journal Article
Language:	English
Published:	Netherlands 01-12-2022
Subjects:	Biological Transport Blood-Brain Barrier Contrast Media Drug Delivery Systems Humans Magnetic Resonance Imaging Microbubbles
Online Access:	Get full text
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Summary:	The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies. In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agents has emerged as a powerful tool for transiently and non-invasively disrupting the BBB in a targeted and image-guided manner, allowing for localized delivery of drugs, genes, or other therapeutic agents. Beyond the delivery of known therapeutics, FUS-mediated BBB opening also demonstrates the potential for use in neuromodulation and the stimulation of a range of cell- and tissue-level physiological responses that may prove beneficial in disease contexts. Clinical trials investigating the safety and efficacy of FUS-mediated BBB opening are well underway, and offer promising non-surgical approaches to treatment of devastating pathologies. This article reviews a range of pre-clinical and clinical studies demonstrating the tremendous potential of FUS to fundamentally change the paradigm of treatment for CNS diseases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 Authors contributed equally.
ISSN:	0169-409X 1872-8294
DOI:	10.1016/j.addr.2022.114583