Search Results - "Hoch, J A"

Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis by Jiang, Min, Shao, Weilan, Perego, Marta, Hoch, James A.

“…Protein homology studies identified five kinases potentially capable of phosphorylating the Spo0F response regulator and initiating sporulation in Bacillus…”
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Developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms by Stephenson, K, Hoch, J A

“…Two-component signal transduction systems and their expanded variants known as phosphorelays are integral elements of the virulence and antimicrobial…”
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Keeping signals straight in phosphorelay signal transduction by Hoch, J A, Varughese, K I

“…Bacteria are highly adaptable organisms, and the key is their capacity to express only those genes for enzymes and pathways that they need for maximal growth…”
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Two-component signal transduction as a target for microbial anti-infective therapy by BARRETT, J. F, HOCH, J. A

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Cell-Cell Communication Regulates the Effects of Protein Aspartate Phosphatases on the Phosphorelay Controlling Development in Bacillus subtilis by Perego, Marta, Hoch, James A.

“…Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F∼ P intermediate of the phosphorelay, thus…”
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Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis by HOCH, J. A

“…The initiation of sporulation of bacteria is a complex cellular event controlled by an extensive network of regulatory proteins that serve to ensure that a…”
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The oligopeptide transport system of Bacillus subtilis plays a role in the initiation of sporulation by Perego, M, Higgins, C F, Pearce, S R, Gallagher, M P, Hoch, J A

“…Bacillus subtilis spo0K mutants are blocked at the first step in sporulation. The spo0K strain was found to contain two mutations: one was linked to the trpS…”
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Antibacterial Agents that Inhibit Two-Component Signal Transduction Systems by Barrett, J. F., Goldschmidt, R. M., Lawrence, L. E., Foleno, B., Chen, R., Demers, J. P., Johnson, S., Kanojia, R., Fernandez, J., Bernstein, J., Licata, L., Donetz, A., Huang, S., Hlasta, D. J., Macielag, M. J., Ohemeng, K., Frechette, R., Frosco, M. B., Klaubert, D. H., Whiteley, J. M., Wang, L., Hoch, J. A.

“…A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of…”
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Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay by Burbulys, D, Trach, K A, Hoch, J A

“…Stage 0 sporulation (spo0) mutants of Bacillus subtilis are defective in the signal transduction system initiating sporulation. Two of the products of these…”
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Deactivation of the sporulation transcription factor Spo0A by the Spo0E protein phosphatase by OHLSEN, K. L, GRIMSLEY, J. K, HOCH, J. A

“…The spo0E locus of Bacillus subtilis codes for a negative regulator of sporulation that, when overproduced, represses sporulation and, if deleted, results in…”
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Two-component and phosphorelay signal transduction by Hoch, James A

“…Two-component and phosphorelay signal transduction systems are the major means by which bacteria recognize and respond to a variety of environmental stimuli…”
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Characterization of the gene for a protein kinase which phosphorylates the sporulation-regulatory proteins Spo0A and Spo0F of Bacillus subtilis by PEREGO, M, COLE, S. P, BURBULYS, D, TRACH, K, HOCH, J. A

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The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein by Strauch, M. A., Spiegelman, G. B., Perego, M., Johnson, W. C., Burbulys, D., Hoch, J. A.

“…The product of the abrB gene of Bacillus subtilis is an ambiactive repressor and activator of the transcription of genes expressed during the transition state…”
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The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein by TRACH, K, HOCH, J. A

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Effects on Bacillus subtilis of a conditional lethal mutation in the essential GTP-binding protein Obg by Kok, J, Trach, K A, Hoch, J A

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Transition-state regulators: sentinels of Bacillus subtilis post-exponential gene expression by Strauch, M A, Hoch, J A

“…When Bacillus subtilis encounters a nutrient-depleted environment, it expresses a wide variety of genes that encode functions in alternative pathways of…”
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Protein aspartate phosphatases control the output of two-component signal transduction systems by Perego, Marta, Hoch, James A.

“…Phosphorylation or dephosphorylation of an aspartate regulates the output activity of the response regulator of two-component signaling systems. Signal input…”
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Negative regulation of Bacillus subtilis sporulation by the spo0E gene product by Perego, M, Hoch, J A

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The SpoOA Protein of Bacillus Subtilis is A Repressor of the abrB Gene by Strauch, Mark, Webb, Vera, Spiegelman, George, Hoch, James A.

“…The spoOA gene of Bacillus subtilis is critical for the initial stages in the developmental cycle leading to the formation of an endospore. We show that one…”
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Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis by Welsh, K M, Trach, K A, Folger, C, Hoch, J A

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