Search Results - "Hoch, Denise"

Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion by Majali-Martinez, Alejandro, Weiss-Fuchs, Ursula, Miedl, Heidi, Forstner, Desiree, Bandres-Meriz, Julia, Hoch, Denise, Djelmis, Josip, Ivanisevic, Marina, Hiden, Ursula, Gauster, Martin, Desoye, Gernot

“…Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy, but a contributing role of the placenta has remained elusive. Thus,…”
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Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy by Bandres-Meriz, Julia, Majali-Martinez, Alejandro, Hoch, Denise, Morante, Milagros, Glasner, Andreas, van Poppel, Mireille N. M., Desoye, Gernot, Herrera, Emilio

“…Maternal obesity in pregnancy is a pro-inflammatory condition exposing the fetus to an adverse environment. Here, we tested associations of maternal obesity…”
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Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1 by Hoch, Denise, Bachbauer, Martina, Pöchlauer, Caroline, Algaba-Chueca, Francisco, Tandl, Veronika, Novakovic, Boris, Megia, Ana, Gauster, Martin, Saffery, Richard, Glasner, Andreas, Desoye, Gernot, Majali-Martinez, Alejandro

“…In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and…”
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FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function by Alqudah, Abdelrahim, Eastwood, Kelly-Ann, Jerotic, Djurdja, Todd, Naomi, Hoch, Denise, McNally, Ross, Obradovic, Danilo, Dugalic, Stefan, Hunter, Alyson J, Holmes, Valerie A, McCance, David R, Young, Ian S, Watson, Chris J, Robson, Tracy, Desoye, Gernot, Grieve, David J, McClements, Lana

“…Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications…”
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Maternal Obesity Affects the Glucose-Insulin Axis During the First Trimester of Human Pregnancy by Bandres-Meriz, Julia, Dieberger, Anna M, Hoch, Denise, Pöchlauer, Caroline, Bachbauer, Martina, Glasner, Andreas, Niedrist, Tobias, van Poppel, Mireille N M, Desoye, Gernot

“…The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. Metabolic changes in obese mothers in early pregnancy…”
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Human Milk Oligosaccharides in Cord Blood Are Altered in Gestational Diabetes and Stimulate Feto-Placental Angiogenesis In Vitro by Hoch, Denise, Brandl, Waltraud, Strutz, Jasmin, Köfeler, Harald C, van Poppel, Mireille N M, Bode, Lars, Hiden, Ursula, Desoye, Gernot, Jantscher-Krenn, Evelyn

“…(1) Background: Human milk oligosaccharides (HMOs) are present in maternal serum during pregnancy and their composition is altered in gestational diabetes…”
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Diabesity-associated oxidative and inflammatory stress signalling in the early human placenta by Hoch, Denise, Gauster, Martin, Hauguel-de Mouzon, Sylvie, Desoye, Gernot

“…Early pregnancy is characterized by a series of complex and tightly regulated events to ultimately establish implantation and early placental development. One…”
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Maternal Smoking in the First Trimester and its Consequence on the Early Placenta by Hoch, Denise, Majali-Martinez, Alejandro, Bankoglu, Ezgi Eyluel, Stopper, Helga, Glasner, Andreas, Desoye, Gernot, Gauster, Martin, Hiden, Ursula

“…Smoking during pregnancy increases the risk of adverse pregnancy outcomes, such as stillbirth and fetal growth restriction. This suggests impaired placental…”
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Sex matters: XIST and DDX3Y gene expression as a tool to determine fetal sex in human first trimester placenta by Hoch, Denise, Novakovic, Boris, Cvitic, Silvija, Saffery, Richard, Desoye, Gernot, Majali-Martinez, Alejandro

“…Fetal sex influences placental function as well as maternal and fetal health, being an important factor to consider in pregnancy studies. However, fetal sex…”
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Different regulation of IRE1α and eIF2α pathways by oxygen and insulin in ACH-3P trophoblast model by Tandl, Veronika, Hoch, Denise, Bandres-Meriz, Julia, Nikodijevic, Sanela, Desoye, Gernot, Majali-Martinez, Alejandro

“…Endoplasmic reticulum (ER)-stress activates the unfolded protein response (UPR), which plays a (patho)physiological role in the placenta. Oxygen and…”
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The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial endothelial cells altered by gestational diabetes mellitus by Tokic, Silvija, Novakovic, Boris, Leopold-Posch, Barbara, Mühlberger, Magdalena, Hoch, Denise, Lögl, Jelena, Bernhart, Eva M, Saffery, Richard, Desoye, Gernot, Hiden, Ursula

“…In utero exposure to gestational diabetes mellitus (GDM) programs the fetus, increasing offspring risk for endothelial dysfunction and cardiovascular disease…”
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Obesity-associated non-oxidative genotoxic stress alters trophoblast turnover in human first-trimester placentas by Hoch, Denise, Majali-Martinez, Alejandro, Bandres-Meriz, Julia, Bachbauer, Martina, Pöchlauer, Caroline, Kaudela, Theresa, Bankoglu, Ezgi Eyluel, Stopper, Helga, Glasner, Andreas, Hauguel-De Mouzon, Sylvie, Gauster, Martin, Tokic, Silvija, Desoye, Gernot

“…Abstract Placental growth is most rapid during the first trimester (FT) of pregnancy, making it vulnerable to metabolic and endocrine influences. Obesity, with…”
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93-OR: Low Maternal Insulin Sensitivity Associates with DNA-Related Functions in Human First-Trimester Trophoblast by BANDRES-MERIZ, JULIA, HOCH, DENISE, HONEDER, SOPHIE, MAJALI-MARTINEZ, ALEJANDRO, HERRERA, EMILIO, SCHITTMAYER, MATTHIAS, BIRNER-GRUENBERGER, RUTH, DESOYE, GERNOT

“…In first trimester (FT) of pregnancy the human placenta is rapidly growing making it sensitive to environmental influence. We hypothesized that the altered…”
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The Minichromosome Maintainance Complex is Up‐regulated in the Placentas of Low‐Insulin Sensitive Mothers in the First Trimester of Pregnancy by Bandres‐Meriz, Julia, Hurtado, Irene, Majali‐Martinez, Alejandro, Hoch, Denise, Honeder, Sophie, Birner‐Grünberger, Ruth, Dalgaard, Louise T., Desoye, Gernot

“…Introduction Obesity in women at reproductive age is increasing worldwide and is a risk factor for pregnancy complications. In the first trimester of pregnancy…”
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Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment by Todd, Naomi, McNally, Ross, Alqudah, Abdelrahim, Jerotic, Djurdja, Suvakov, Sonja, Obradovic, Danilo, Hoch, Denise, Hombrebueno, Jose R, Campos, Guillermo Lopez, Watson, Chris J, Gojnic-Dugalic, Miroslava, Simic, Tatjana P, Krasnodembskaya, Anna, Desoye, Gernot, Eastwood, Kelly-Ann, Hunter, Alyson J, Holmes, Valerie A, McCance, David R, Young, Ian S, Grieve, David J, Kenny, Louise C, Garovic, Vesna D, Robson, Tracy, McClements, Lana

“…Abstract Context Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies. Objective To…”
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Dendritic polyglycerol nanoparticles show charge dependent bio-distribution in early human placental explants and reduce hCG secretion by Juch, Herbert, Nikitina, Liudmila, Reimann, Sabine, Gauster, Martin, Dohr, Gottfried, Obermayer-Pietsch, Barbara, Hoch, Denise, Kornmueller, Karin, Haag, Rainer

“…A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application…”
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Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity by Majali‐Martinez, Alejandro, Hoch, Denise, Tam‐Amersdorfer, Carmen, Pollheimer, Jürgen, Glasner, Andreas, Ghaffari‐Tabrizi‐Wizsy, Nassim, Beristain, Alexander G., Hiden, Ursula, Dieber‐Rotheneder, Martina, Desoye, Gernot

“…Adequate anchoring of the placenta in the uterus through invasion of first trimester cytotrophoblasts (CTB) is required for a successful pregnancy. This…”
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Angiotensin II upregulates Placental Leptin and has a Potential Inflammatory Role in Early Gestation Placenta by Nonn, Olivia, Maninger, Sabine, El-Heliebi, Amin, Kroneis, Thomas, Forstner, Désirée, Guettler, Jaqueline, Siwetz, Monika, Herse, Florian, Hiden, Ursula, Hoch, Denise, Desoye, Gernot, Huppertz, Berthold, Gauster, Martin

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