A protein kinase inhibitor from A431 subline overexpressing TGF alpha possesses antimicrobial activity

During the last decade the key role of antimicrobial peptides in innate immunity has been argued. They were found in plants and in different phylogenic groups of animals (insects, amphibia, and even in mammals). We report the production of a human peptide antibiotic that was previously characterized...

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Bibliographic Details
Published in:	The New microbiologica Vol. 21; no. 3; p. 269
Main Authors:	Pogrebnoy, P V, Hobta, A I, Soldatkina, M A, Garmanchouk, L V, Markeeva, N V, Eremenko, T
Format:	Journal Article
Language:	English
Published:	Italy 01-07-1998
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Carcinoma, Squamous Cell Cell Line - chemistry Cell Line - secretion Chromatography, High Pressure Liquid Electrophoresis, Polyacrylamide Gel Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Humans Protein Kinase Inhibitors Transforming Growth Factor alpha - metabolism
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Summary:	During the last decade the key role of antimicrobial peptides in innate immunity has been argued. They were found in plants and in different phylogenic groups of animals (insects, amphibia, and even in mammals). We report the production of a human peptide antibiotic that was previously characterized as an EGF receptor tyrosine kinase inhibitor in epidermoid carcinoma A431/1522 cell subline overexpressing TGF alpha. It is a 3 kDa hydrophobic cationic peptide cytotoxic for different species of Gr+ and Gr- bacteria in micromolar concentration range, and demonstrating slight fungicidal activity.
ISSN:	1121-7138