Search Results - "Hobman, Tom"

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19 by Bernard, Isabelle, Limonta, Daniel, Mahal, Lara K, Hobman, Tom C

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to…”
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Zika virus inhibits type-I interferon production and downstream signaling by Kumar, Anil, Hou, Shangmei, Airo, Adriana M, Limonta, Daniel, Mancinelli, Valeria, Branton, William, Power, Christopher, Hobman, Tom C

“…Zika virus is an emerging mosquito‐borne pathogen that is associated with Guillain–Barré syndrome in adults and microcephaly and other neurological defects in…”
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Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells by Knoblach, Barbara, Ishida, Ray, Hobman, Tom C, Rachubinski, Richard A

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has triggered global health and economic crises. Here we report the…”
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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 by Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Lim, Shion A., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.

“…An essential mechanism for severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology by Xu, Zaikun, Asahchop, Eugene L, Branton, William G, Gelman, Benjamin B, Power, Christopher, Hobman, Tom C

“…HIV-associated neurocognitive disorders (HAND) represent a spectrum neurological syndrome that affects up to 25% of patients with HIV/AIDS. Multiple pathogenic…”
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IGF1R is an entry receptor for respiratory syncytial virus by Griffiths, Cameron D., Bilawchuk, Leanne M., McDonough, John E., Jamieson, Kyla C., Elawar, Farah, Cen, Yuchen, Duan, Wenming, Lin, Cindy, Song, Haeun, Casanova, Jean-Laurent, Ogg, Steven, Jensen, Lionel Dylan, Thienpont, Bernard, Kumar, Anil, Hobman, Tom C., Proud, David, Moraes, Theo J., Marchant, David J.

“…Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large…”
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Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response by Hou, Shangmei, Kumar, Anil, Xu, Zaikun, Airo, Adriana M, Stryapunina, Iryna, Wong, Cheung Pang, Branton, William, Tchesnokov, Egor, Götte, Matthias, Power, Christopher, Hobman, Tom C

“…Zika virus (ZIKV), a member of the family, has recently emerged as an important human pathogen with increasing economic and health impact worldwide. Because of…”
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SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors by Kumar, Anil, Ishida, Ray, Strilets, Tania, Cole, Jamie, Lopez-Orozco, Joaquin, Fayad, Nawell, Felix-Lopez, Alberto, Elaish, Mohamed, Evseev, Danyel, Magor, Katharine E, Mahal, Lara K, Nagata, Les P, Evans, David H, Hobman, Tom C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous…”
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Human Sertoli cells support high levels of Zika virus replication and persistence by Kumar, Anil, Jovel, Juan, Lopez-Orozco, Joaquin, Limonta, Daniel, Airo, Adriana M., Hou, Shangmei, Stryapunina, Iryna, Fibke, Chad, Moore, Ronald B., Hobman, Tom C.

“…Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain–Barré syndrome in adults. The virus…”
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Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression by Zhang, Ke, Miorin, Lisa, Makio, Tadashi, Dehghan, Ishmael, Gao, Shengyan, Xie, Yihu, Zhong, Hualin, Esparza, Matthew, Kehrer, Thomas, Kumar, Anil, Hobman, Tom C, Ptak, Christopher, Gao, Boning, Minna, John D, Chen, Zhijian, García-Sastre, Adolfo, Ren, Yi, Wozniak, Richard W, Fontoura, Beatriz M A

“…The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host…”
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Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2 by Nguyen, Linh, McCord, Kelli A., Bui, Duong T., Bouwman, Kim M., Kitova, Elena N., Elaish, Mohamed, Kumawat, Dhanraj, Daskhan, Gour C., Tomris, Ilhan, Han, Ling, Chopra, Pradeep, Yang, Tzu-Jing, Willows, Steven D., Mason, Andrew L., Mahal, Lara K., Lowary, Todd L., West, Lori J., Hsu, Shang-Te Danny, Hobman, Tom, Tompkins, Stephen M., Boons, Geert-Jan, de Vries, Robert P., Macauley, Matthew S., Klassen, John S.

“…Emerging evidence suggests that host glycans influence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the…”
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The nucleolar helicase DDX56 redistributes to West Nile virus assembly sites by Reid, Colleen R, Hobman, Tom C

“…Abstract Flaviviruses, including the human pathogen, West Nile virus (WNV), are known to co-opt many host factors for their replication and propagation. To…”
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The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism by Urbanowski, Matt D, Hobman, Tom C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence by Limonta, Daniel, Jovel, Juan, Kumar, Anil, Airo, Adriana M, Hou, Shangmei, Saito, Leina, Branton, William, Ka-Shu Wong, Gane, Mason, Andrew, Power, Christopher, Hobman, Tom C

“…Zika virus (ZIKV) infection and persistence during pregnancy can lead to microcephaly and other fetal neurological disorders collectively known as Congenital…”
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The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles by Xu, Zaikun, Hobman, Tom C

“…Abstract Although flaviviruses encode their own helicases, evidence suggests that cellular helicases are also required for replication and/or assembly of these…”
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Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2 by Limonta, Daniel, Dyna-Dagman, Lovely, Branton, William, Mancinelli, Valeria, Makio, Tadashi, Wozniak, Richard W, Power, Christopher, Hobman, Tom C

“…In the present report, we describe two small molecules with broad-spectrum antiviral activity. These drugs block the formation of the nodosome. The studies…”
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The Capsid-Binding Nucleolar Helicase DDX56 Is Important for Infectivity of West Nile Virus by Xu, Zaikun, Anderson, Robert, Hobman, Tom C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Unique Cofactor Region of Zika Virus NS2B–NS3 Protease Facilitates Cleavage of Key Host Proteins by Hill, Maureen E, Kumar, Anil, Wells, James A, Hobman, Tom C, Julien, Olivier, Hardy, Jeanne A

“…Zika virus is an emerging mosquito-borne pathogen capable of severely damaging developing fetuses as well as causing neurological abnormalities in adults. The…”
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West Nile virus infection causes endocytosis of a specific subset of tight junction membrane proteins by Xu, Zaikun, Waeckerlin, Regula, Urbanowski, Matt D, van Marle, Guido, Hobman, Tom C

“…West Nile virus (WNV) is a blood-borne pathogen that causes systemic infections and serious neurological disease in human and animals. The most common route of…”
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Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling by You, Jaehwan, Hou, Shangmei, Malik-Soni, Natasha, Xu, Zaikun, Kumar, Anil, Rachubinski, Richard A, Frappier, Lori, Hobman, Tom C

“…Flaviviruses are significant human pathogens that have an enormous impact on the global health burden. Currently, there are very few vaccines against or…”
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