Search Results - "Hobeika, AC"

Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients by Crosby, EJ, Gwin, WR, Chang, S, Maecker, HT, Lubkov, V, Snyder, JC, Broadwater, G, Hyslop, T, Osada, T, Hobeika, AC, Hartman, ZC, Morse, MA, Lyerly, HK

“…Background: Immune-based therapy for metastatic breast cancer has had limited success. Strategies to augment adaptive immunity include vaccines targeting…”
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Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules by MORSE, Michael A, CLAY, Timothy M, HOBEIKA, Amy C, OSADA, Takuya, KHAN, Shubi, CHUI, Stephen, NIEDZWIECKI, Donna, PANICALI, Dennis, SCHLOM, Jeffrey, LYERLY, H. Kim

“…Purpose: To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor…”
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Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer by CLAY, Timothy M, HOBEIKA, Amy C, MOSCA, Paul J, LYERLY, H. Kim, MORSE, Michael A

“…Numerous cancer immunotherapy strategies are currently being tested in clinical trials. Although clinical efficacy will be the final test of these approaches,…”
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P1-13-03: Zoledronic Acid Induces an Immune Response in Breast Cancer Patients through Stimulation of Central Memory and Effector Memory gamma/delta T-Cells by Hamilton, EP, Hobeika, AC, Lyerly, HK, Owzar, K, Rocha, G, Kimmick, GG, Marcom, PK, Peppercorn, JM, Morse, MA, Blackwell, KL

“…Background Zoledronic acid (ZA) in combination with endocrine therapy (ET) and ovarian ablation (OA) reported a DFS advantage in premenopausal women with early…”
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Immunotherapy with Autologous, Human Dendritic Cells Transfected with Carcinoembryonic Antigen mRNA by Morse, Michael A., Nair, Smita K., Mosca, Paul J., Hobeika, Amy C., Clay, Timothy M., Deng, Yuping, Boczkowski, David, Proia, Alan, Neidzwiecki, Donna, Clavien#, Pierre-A., Hurwitz, Herbert I., Schlom, Jeffrey, Gilboa, Eli, Lyerly, H. Kim

“…Immunizations with dendritic cells (DC) transfected with RNA encoding tumor antigens induce potent tumor antigen-specific immune responses in vitro and in…”
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Enumerating antigen-specific T-cell responses in peripheral blood: A comparison of peptide MHC tetramer, ELISpot, and intracellular cytokine analysis by HOBEIKA, Amy C, MORSE, Michael A, OSADA, Takuya, GHANAYEM, Manar, NIEDZWIECKI, Donna, BARRIER, Robert, LYERLY, H. Kim, CLAY, Timothy M

“…Detection of the circulating antigen-specific T-cell response to immunization is an important biologic end point in clinical trials of cancer vaccines…”
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A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment by Mosca, Paul J., Hobeika, Amy C., Clay, Timothy M., Nair, Smita K., Thomas, Elaine K., Morse, Michael A., Lyerly, H. Kim

“…Dendritic cells (DCs) may arise from multiple lineages and progress through a series of intermediate stages until fully mature, at which time they are capable…”
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Superantigens: the good, the bad, and the ugly by Torres, B A, Kominsky, S, Perrin, G Q, Hobeika, A C, Johnson, H M

“…Increasing evidence suggests that superantigens play a role in immune-mediated diseases. Superantigens are potent activators of CD4+ T cells, causing rapid and…”
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Down-regulation of neu/HER-2 by interferon-γ in prostate cancer cells by KOMINSKY, S. L, HOBEIKA, A. C, LAKE, F. A, TORRES, B. A, JOHNSON, H. M

“…Interferons (IFNs) are known to possess potent antitumor properties. Previous studies have indicated that IFNs are capable of modulating the expression of…”
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IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells by HOBEIKA, A. C, SUBRAMANIAM, P. S, JOHNSON, H. M

“…Prostate cancer, like other types of cancer, is associated with the loss of cell cycle control, resulting in unregulated growth of cells. We report here on the…”
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Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease by Hobeika, A.C, Osada, T, Serra, D, Peplinski, S, Hanson, K, Tanaka, Y, Niedzwiecki, D, Chao, N, Rizzieri, D, Lyerly, H.K, Clay, T, Morse, M.A., MD

“…Background Cytomegalovirus (CMV) infection and its treatment causes significant morbidity following allogeneic stem cell transplantation (SCT) for…”
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Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand by Mosca, Paul J, Hobeika, Amy C., Colling, Kirsten, Clay, Timothy M., Thomas, Elaine K., Caron, Dania, Lyerly, H. Kim, Morse, Michael A.

“…The ligand for the receptor tyrosine kinase fms‐like tyrosine kinase 3(Flt3L) is a growth factor for hematopoietic progenitors and inducesexpansion of the two…”
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IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis by Hobeika, A C, Etienne, W, Torres, B A, Johnson, H M, Subramaniam, P S

“…Interferons (IFN) inhibit the growth of tumor cells by blocking the progression of their cell cycle. Recently, we showed that this cell cycle inhibition…”
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Superantigen enhanced protection against a weak tumor‐specific melanoma antigen: Implications for prophylactic vaccination against cancer by Kominsky, Scott L., Torres, Barbara A., Hobeika, Amy C., Lake, Faith A., Johnson, Howard M.

“…B16F10 melanoma is a tumor derived from C57BL/6 mice that has been found to be poorly immunogenic and highly aggressive. Here we have shown that vaccination of…”
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The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity by Soos, JM, Subramaniam, PS, Hobeika, AC, Schiffenbauer, J, Johnson, HM

“…Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease if the central nervous system (CNS). Recently, the type I IFN, IFN-beta-1b was…”
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Direct detection of cellular immune responses to cancer vaccines by Mosca, Paul J., Hobeika, Amy C., Clay, Timothy M., Morse, Michael A., Lyerly, H.Kim

“…The evaluation of cancer immunotherapy is predicated on the hypothesis that markers of tumor antigen-specific T-cell immunity will cone-late with clinical…”
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Quantitating therapeutically relevant T-cell responses to cancer vaccines by Hobeika, A C, Clay, T M, Mosca, P J, Lyerly, H K, Morse, M A

“…Successful application of active immunotherapy to the treatment of cancer will require stimulation of potent antigen-specific T-cell responses. It is not known…”
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A Neutralizing Epitope of the Superantigen SEA Has Agonist Activity on T Cells by Hobeika, Amy C., Johnson, Howard M.

“…We have previously shown that sequence 121–149 of the staphylococcal enterotoxin superantigen SEA plays an important role in superantigen function. A synthetic…”
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Surrogate markers of response to cancer immunotherapy by Morse, M A, Clay, T M, Hobeika, A C, Mosca, P J, Lyerly, H K

“…Clinically effective cancer immunotherapy has been sought for more than 100 years and has been recently applied most successfully in strategies that passively…”
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Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants by Morse, Michael A, Rizzieri, David, Stenzel, Timothy T, Hobeika, Amy C, Vredenburgh, James J, Chao, Nelson J, Clay, Timothy M, Mosca, Paul J, Lyerly, H Kim

“…Nonmyeloablative allogeneic stem cell transplantation (NMSCT) may destroy some malignancies through a graft-versus-tumor (GVT) effect, but tumor relapse and…”
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