Search Results - "Hobeika, A."

Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients’ preference-based study (PPPS) by Zhao, Y., Qiao, G., Wang, X., Song, Y., Zhou, X., Jiang, N., Zhou, L., Huang, H., Zhao, J., Morse, M. A., Hobeika, A., Ren, J., Lyerly, H. K.

“…Background Advanced non-small cell lung cancer (NSCLC) has remained challenging to treat effectively. This study aimed to investigate the clinical effects and…”
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Optimal evacuation planning using staging and routing by Bish, D R, Sherali, H D, Hobeika, A G

“…Evacuation is an important disaster management tool. Evacuating a large region by automobile (the most commonly used mode) is a difficult task, especially as…”
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Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA CD3-bispecific T-cell-engaging BiTE antibody by Osada, T, Hsu, D, Hammond, S, Hobeika, A, Devi, G, Clay, T M, Lyerly, H K, Morse, M A

“…Background: Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human colorectal cancer (CRC)…”
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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers by Sinnathamby, G, Zerfass, J, Hafner, J, Block, P, Nickens, Z, Hobeika, A, Secord, A.A, Lyerly, H.K, Morse, M.A, Philip, R

“…Selection of suitable antigens is critical for the development of cancer vaccines. Most desirable are over-expressed cell surface proteins that may serve as…”
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A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment by Mosca, Paul J., Hobeika, Amy C., Clay, Timothy M., Nair, Smita K., Thomas, Elaine K., Morse, Michael A., Lyerly, H. Kim

“…Dendritic cells (DCs) may arise from multiple lineages and progress through a series of intermediate stages until fully mature, at which time they are capable…”
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Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function by Morse, M A, Hobeika, A, Serra, D, Aird, K, McKinney, M, Aldrich, A, Clay, T, Mourich, D, Lyerly, H K, Iversen, P L, Devi, G R

“…CD4+CD25+regulatory T cells (T reg ) impair anti-tumor and anti-viral immunity. As there are higher T reg levels in cancer patients compared with healthy…”
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Down-regulation of neu/HER-2 by interferon-γ in prostate cancer cells by KOMINSKY, S. L, HOBEIKA, A. C, LAKE, F. A, TORRES, B. A, JOHNSON, H. M

“…Interferons (IFNs) are known to possess potent antitumor properties. Previous studies have indicated that IFNs are capable of modulating the expression of…”
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Evaluation Update of the Red Light Camera Program in Fairfax County, VA by Hobeika, A., Yaungyai, N.

“…The Red Light Camera (RLC) program in Fairfax County, VA, had 13 cameras in operation in year 2003. This update study is conducted to evaluate the Fairfax…”
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IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells by HOBEIKA, A. C, SUBRAMANIAM, P. S, JOHNSON, H. M

“…Prostate cancer, like other types of cancer, is associated with the loss of cell cycle control, resulting in unregulated growth of cells. We report here on the…”
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Liquid helium up to 160 bar by WERNER, F, BEAUME, G, HOBEIKA, A, NASCIMBENE, S, HERRMANN, C, CAUPIN, F, BALIBAR, S

“…We have used an acoustic technique to pressurize liquid helium 4 up to 163 - 20 bar. This is far above the liquid-solid equilibrium pressure Pm, which is 25.3…”
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Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer by CLAY, Timothy M, HOBEIKA, Amy C, MOSCA, Paul J, LYERLY, H. Kim, MORSE, Michael A

“…Numerous cancer immunotherapy strategies are currently being tested in clinical trials. Although clinical efficacy will be the final test of these approaches,…”
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The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity by Soos, JM, Subramaniam, PS, Hobeika, AC, Schiffenbauer, J, Johnson, HM

“…Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease if the central nervous system (CNS). Recently, the type I IFN, IFN-beta-1b was…”
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En bloc resection of lacrimal sac tumors and simultaneous orbital reconstruction: surgical and functional outcomes by Alabiad, Chrisfouad R, Weed, Donald T, Walker, Thomas J, Vivero, Richard, Hobeika, Georges A, Hatoum, Georges F, Shriver, Erin M, Tse, David T

“…To describe a surgical technique of en bloc resection of lacrimal sac tumors by the shared expertise of 2 specialists to achieve optimal tumor margin clearance…”
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Comparison of traffic assignments in evacuation modeling by Hobeika, A.G., Changkyun Kim

“…The Nuclear Regulatory Commission (NRC) requires that all electric utilities develop and update evacuation plans for the areas surrounding their nuclear power…”
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Superantigens: the good, the bad, and the ugly by Torres, B A, Kominsky, S, Perrin, G Q, Hobeika, A C, Johnson, H M

“…Increasing evidence suggests that superantigens play a role in immune-mediated diseases. Superantigens are potent activators of CD4+ T cells, causing rapid and…”
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Time-Dependent, Label-Constrained Shortest Path Problems with Applications by Sherali, Hanif D, Hobeika, Antoine G, Kangwalklai, Sasikul

“…In this paper, we consider a variant of shortest path problems where, in addition to congestion related time-dependent link travel times on a given…”
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Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand by Mosca, Paul J, Hobeika, Amy C., Colling, Kirsten, Clay, Timothy M., Thomas, Elaine K., Caron, Dania, Lyerly, H. Kim, Morse, Michael A.

“…The ligand for the receptor tyrosine kinase fms‐like tyrosine kinase 3(Flt3L) is a growth factor for hematopoietic progenitors and inducesexpansion of the two…”
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IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis by Hobeika, A C, Etienne, W, Torres, B A, Johnson, H M, Subramaniam, P S

“…Interferons (IFN) inhibit the growth of tumor cells by blocking the progression of their cell cycle. Recently, we showed that this cell cycle inhibition…”
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Surrogate markers of response to cancer immunotherapy by Morse, M A, Clay, T M, Hobeika, A C, Mosca, P J, Lyerly, H K

“…Clinically effective cancer immunotherapy has been sought for more than 100 years and has been recently applied most successfully in strategies that passively…”
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The values and risks of an Intergovernmental Panel for One Health to strengthen pandemic prevention, preparedness, and response by Hobeika, Alexandre, Stauffer, Maxime Henri Tibault, Dub, Timothée, van Bortel, Wim, Beniston, Martin, Bukachi, Salome, Burci, Gian Luca, Crump, Lisa, Markotter, Wanda, Sepe, Ludovico Pasquale, Placella, Enrichetta, Roche, Benjamin, Thiongane, Oumy, Wang, Zhanyun, Guérin, Frédérique, van Kleef, Esther

“…The COVID-19 pandemic has shown the need for better global governance of pandemic prevention, preparedness, and response (PPR) and has emphasised the…”
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