Search Results - "Hobbs, Theodore R"
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A Comparison of Oocyte Yield between Ultrasound-Guided and Laparoscopic Oocyte Retrieval in Rhesus Macaques
Published in Animals (Basel) (26-09-2023)“…Obtaining quality oocytes is a prerequisite for ART-based studies. Here we describe a method for transabdominal ultrasound-guided (US) oocyte retrieval in…”
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Preclinical Development of a Prophylactic Neuroprotective Therapy for the Preventive Treatment of Anticipated Ischemia-Reperfusion Injury
Published in Translational stroke research (01-08-2017)“…Ischemia-reperfusion brain injury can be iatrogenically induced secondary to life-saving procedures. Prophylactic treatment of these patients offers a…”
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Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2013)“…The strict tropism of many pathogens for man hampers the development of animal models that recapitulate important microbehost interactions. We developed a…”
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A new model of cortical stroke in the rhesus macaque
Published in Journal of cerebral blood flow and metabolism (01-06-2009)“…Primate models are essential tools for translational research in stroke but are reportedly inconsistent in their ability to produce cortical infarcts of…”
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Augmentation of Pulmonary Perfusion by Conducted Effects of a Pulmonary Artery Ultrasound Catheter
Published in Ultrasound in medicine & biology (01-10-2022)“…Ultrasound (US) generated by catheters used clinically for US-facilitated thrombolysis can release shear-dependent vasodilators from endothelial and red blood…”
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Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
Published in Immunity (Cambridge, Mass.) (11-07-2023)“…Allogeneic hematopoietic stem cell transplantation (alloHSCT) from donors lacking C-C chemokine receptor 5 (CCR5Δ32/Δ32) can cure HIV, yet mechanisms remain…”
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Treatment of Limb Ischemia with Conducted Effects of Catheter-Based Endovascular Ultrasound
Published in Ultrasound in medicine & biology (01-08-2021)“…Ultrasound (US) is known to stimulate endogenous shear-dependent pathways, and can lower microvascular resistance through mediators that are conducted…”
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IACUC Review of Nonhuman Primate Research
Published in ILAR journal (01-01-2013)“…This article will detail some of the issues that must be considered as institutional animal care and use committees (IACUCs) review the use of nonhuman…”
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Non-bronchoscopic Bronchoalveolar Lavage as a Refinement for Safely Obtaining High-quality Samples from Macaques
Published in Comparative medicine (01-12-2020)“…Nonbronchoscopic bronchoalveolar lavage (NB-BAL) is a minimally invasive diagnostic and research tool used to sample the cells of lower airways and alveoli…”
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Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke
Published in Journal of cerebral blood flow and metabolism (01-05-2011)“…Cerebral ischemic injury is a significant portion of the burden of disease in developed countries; rates of mortality are high and the costs associated with…”
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Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications
Published in Xenotransplantation (Københaven) (01-07-2020)“…Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus‐associated complications…”
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Efficacy of Oral Fecal Bacteriotherapy in Rhesus Macaques (Macaca mulatta) with Chronic Diarrhea
Published in Comparative medicine (01-02-2013)“…Chronic diarrhea remains the principal burden in providing health care for nonhuman primates in biomedical research facilities. Although the exact etiology…”
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In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles
Published in Methods (San Diego, Calif.) (01-09-2009)“…Non-human primates (NHPs) are an invaluable resource for the study of genetic regulation of disease mechanisms. The main disadvantage of using NHPs as a…”
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Measurement of Blood Volume in Adult Rhesus Macaques (Macaca mulatta)
Published in Journal of the American Association for Laboratory Animal Science (01-11-2015)“…Most biomedical facilities that use rhesus macaques (Macaca mulatta) limit the amount of blood that may be collected for experimental purposes. These limits…”
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Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model
Published in Reproductive sciences (Thousand Oaks, Calif.) (01-01-2013)“…We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. A total of 20 rhesus…”
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Comparison of Lactate, Base Excess, Bicarbonate, and pH as Predictors of Mortality after Severe Trauma in Rhesus Macaques (Macaca mulatta)
Published in Comparative medicine (01-06-2010)“…Social group housing of rhesus macaques at biomedical facilities is advocated to improve the psychologic wellbeing of these intelligent and social animals. An…”
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Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance
Published in Reproductive sciences (Thousand Oaks, Calif.) (01-08-2010)“…We hypothesized that fetal ventricular diastolic filling characteristics are related to fetal heart rate (FHR) and pulmonary vascular impedance. Rhesus monkeys…”
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Abdominal cysticercosis in a rhesus macaque (Macaca mulatta)
Published in Comparative medicine (01-10-2003)“…A mid-abdominal mass was discovered during routine physical examination of a rhesus macaque (Macaca mulatta). Further diagnostics and exploratory laparotomy…”
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Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected anti-retroviral therapy-suppressed macaques
Published in Immunity (Cambridge, Mass.) (25-05-2023)“…Allogeneic hematopoietic stem cell transplantation (alloHSCT) from donors lacking C-C chemokine receptor 5 (CCR5 Δ32/Δ32 ) can cure HIV, yet mechanisms remain…”
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