Search Results - "Hobbs, P"

The expanding significance of keratin intermediate filaments in normal and diseased epithelia by Pan, Xiaoou, Hobbs, Ryan P, Coulombe, Pierre A

“…Intermediate filaments are assembled from a diverse group of evolutionary conserved proteins and are specified in a tissue-dependent, cell type-dependent, and…”
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Histology-agnostic drug development — considering issues beyond the tissue by Pestana, Roberto Carmagnani, Sen, Shiraj, Hobbs, Brian P., Hong, David S.

“…With advances in tumour biology and immunology that continue to refine our understanding of cancer, therapies are now being developed to treat cancers on the…”
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Phosphorus Recovery from Wastewater by Struvite Crystallization: A Review by Le Corre, K. S., Valsami-Jones, E., Hobbs, P., Parsons, S. A.

“…The present review provides an understanding of principles of struvite crystallization and examines the techniques and processes experimented to date by…”
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Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer by Lin, Steven H, Hobbs, Brian P, Verma, Vivek, Tidwell, Rebecca S, Smith, Grace L, Lei, Xiudong, Corsini, Erin M, Mok, Isabel, Wei, Xiong, Yao, Luyang, Wang, Xin, Komaki, Ritsuko U, Chang, Joe Y, Chun, Stephen G, Jeter, Melenda D, Swisher, Stephen G, Ajani, Jaffer A, Blum-Murphy, Mariela, Vaporciyan, Ara A, Mehran, Reza J, Koong, Albert C, Gandhi, Saumil J, Hofstetter, Wayne L, Hong, Theodore S, Delaney, Thomas F, Liao, Zhongxing, Mohan, Radhe

“…Whether dosimetric advantages of proton beam therapy (PBT) translate to improved clinical outcomes compared with intensity-modulated radiation therapy (IMRT)…”
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Hierarchical Commensurate and Power Prior Models for Adaptive Incorporation of Historical Information in Clinical Trials by Hobbs, Brian P., Carlin, Bradley P., Mandrekar, Sumithra J., Sargent, Daniel J.

“…Bayesian clinical trial designs offer the possibility of a substantially reduced sample size, increased statistical power, and reductions in cost and ethical…”
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Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy by Shiraishi, Yutaka, Fang, Penny, Xu, Cai, Song, Juhee, Krishnan, Sunil, Koay, Eugene J., Mehran, Reza J., Hofstetter, Wayne L., Blum-Murphy, Mariela, Ajani, Jaffer A., Komaki, Ritsuko, Minsky, Bruce, Mohan, Radhe, Hsu, Charles C., Hobbs, Brian P., Lin, Steven H.

“…Circulating lymphocytes are exquisitely sensitive to radiation exposure, even to low scattered doses which can vary drastically between radiation modalities…”
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Controlled multi-arm platform design using predictive probability by Hobbs, Brian P, Chen, Nan, Lee, J Jack

“…The process of screening agents one-at-a-time under the current clinical trials system suffers from several deficiencies that could be addressed in order to…”
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A Multi-Source Adaptive Platform Design for Testing Sequential Combinatorial Therapeutic Strategies by Kaizer, Alexander M., Hobbs, Brian P., Koopmeiners, Joseph S.

“…Traditional paradigms for clinical translation are challenged in settings where multiple contemporaneous therapeutic strategies have been identified as…”
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Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo by Hobbs, R P, Batazzi, A S, Han, M C, Coulombe, P A

“…Despite preventive human papilloma virus (HPV) vaccination efforts, cervical cancer remains a leading cause of death in women worldwide. Development of…”
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Machine learning identifies prognostic subtypes of the tumor microenvironment of NSCLC by Yu, Duo, Kane, Michael J., Koay, Eugene J., Wistuba, Ignacio I., Hobbs, Brian P.

“…The tumor microenvironment (TME) plays a fundamental role in tumorigenesis, tumor progression, and anti-cancer immunity potential of emerging cancer…”
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Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Comprehensive Analysis of Randomized Phase 2B Trial of Proton Beam Therapy Versus Intensity Modulated Radiation Therapy by Wang, Xin, van Rossum, Peter S N, Chu, Yan, Hobbs, Brian P, Grassberger, Clemens, Hong, Theodore S, Liao, Zhongxing, Yang, Jinzhong, Zhang, Xiaodong, Netherton, Tucker, Mohan, Radhe, Lin, Steven H

“…Lymphocytes play an important role in antitumor immunity; however, they are also especially vulnerable to depletion during chemoradiation therapy (CRT). The…”
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Bioenergy from permanent grassland – A review: 2. Combustion by Prochnow, A., Heiermann, M., Plöchl, M., Amon, T., Hobbs, P.J.

“…The aim of this review is to summarize current knowledge on suitability and sustainability of grassland biomass for combustion. In the first section grassland…”
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Development and Validation of a Predictive Radiomics Model for Clinical Outcomes in Stage I Non-small Cell Lung Cancer by Yu, Wen, Tang, Chad, Hobbs, Brian P., Li, Xiao, Koay, Eugene J., Wistuba, Ignacio I., Sepesi, Boris, Behrens, Carmen, Rodriguez Canales, Jaime, Parra Cuentas, Edwin Roger, Erasmus, Jeremy J., Court, Laurence E., Chang, Joe Y.

“…To develop and validate a radiomics signature that can predict the clinical outcomes for patients with stage I non-small cell lung cancer (NSCLC). We…”
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Characterizing Peridotite Xenoliths From Southern Vietnam: Insight Into the Underlying Lithospheric Mantle by Hobbs, Kirby P., Elkins, Lynne J., Lassiter, John C., Hoang, Nguyen, Burberry, Caroline M.

“…We present data for lithospheric mantle xenoliths sampled from two alkali basalts in south‐central Vietnam, Pleiku and Xuan Loc, including fertile spinel…”
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TDS load contribution from acid mine drainage to Hartbeespoort Dam, South Africa by Hobbs, P.

“…Evidence of a mine-water impact on groundwater in the karst aquifer downstream of the actively draining West Rand Goldfield can be traced back to the early…”
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Definitive Chemoradiation Therapy for Esophageal Cancer in the Elderly: Clinical Outcomes for Patients Exceeding 80 Years Old by Xu, Cai, Xi, Mian, Moreno, Amy, Shiraishi, Yutaka, Hobbs, Brian P., Huang, Meilin, Komaki, Ritsuko, Lin, Steven H.

“…The optimal treatment approach for patients ≥80 years (“elderly”) with esophageal cancer is not well established. We assessed the clinical outcomes in elderly…”
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Commensurate Priors for Incorporating Historical Information in Clinical Trials Using General and Generalized Linear Models by Hobbs, Brian P, Sargent, Daniel J, Carlin, Bradley P

“…Assessing between-study variability in the context of conventional random-effects meta-analysis is notoriously difficult when incorporating data from only a…”
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Basket Trials: Review of Current Practice and Innovations for Future Trials by Hobbs, Brian P, Pestana, Roberto Carmagnani, Zabor, Emily C, Kaizer, Alexander M, Hong, David S

“…Advances in biology and immunology have elucidated genetic and immunologic origins of cancer. Innovations in sequencing technologies revealed that distinct…”
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Adaptive adjustment of the randomization ratio using historical control data by Hobbs, Brian P, Carlin, Bradley P, Sargent, Daniel J

“…Background Prospective trial design often occurs in the presence of ‘acceptable’ historical control data. Typically, these data are only utilized for treatment…”
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Hypocalcemia in trauma patients receiving massive transfusion by Giancarelli, Amanda, PharmD, BCCCP, CNSC, Birrer, Kara L., PharmD, BCPS, Alban, Rodrigo F., MD, FACS, Hobbs, Brandon P., PharmD, BCPS, Liu-DeRyke, Xi, PharmD, FCCM

“…Abstract Background Massive transfusion protocol (MTP) is increasingly used in civilian trauma resuscitation. Calcium is vital for coagulation, but…”
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