Search Results - "Hobbs, Frank"

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase by Favata, M F, Horiuchi, K Y, Manos, E J, Daulerio, A J, Stradley, D A, Feeser, W S, Van Dyk, D E, Pitts, W J, Earl, R A, Hobbs, F, Copeland, R A, Magolda, R L, Scherle, P A, Trzaskos, J M

“…The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based…”
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Synthesis, Structure−Activity Relationships, and In Vivo Evaluation of N 3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists by Hartz, Richard A, Ahuja, Vijay T, Arvanitis, Argyrios G, Rafalski, Maria, Yue, Eddy W, Denhart, Derek J, Schmitz, William D, Ditta, Jonathan L, Deskus, Jeffrey A, Brenner, Allison B, Hobbs, Frank W, Payne, Joseph, Lelas, Snjezana, Li, Yu-Wen, Molski, Thaddeus F, Mattson, Gail K, Peng, Yong, Wong, Harvey, Grace, James E, Lentz, Kimberley A, Qian-Cutrone, Jingfang, Zhuo, Xiaoliang, Shu, Yue-Zhong, Lodge, Nicholas J, Zaczek, Robert, Combs, Andrew P, Olson, Richard E, Bronson, Joanne J, Mattson, Ronald J, Macor, John E

“…Evidence suggests that corticotropin-releasing factor-1 (CRF1) receptor antagonists may offer therapeutic potential for the treatment of diseases associated…”
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase by HAQUE, Tasir S., TADESSE, Seifu, MARCINKEVICIENE, Jovita, ROGERS, M. John, SIZEMORE, Christine, KOPCHO, Lisa M., AMSLER, Karen, ECRET, Lisa D., ZHAN, Dong Liang, HOBBS, Frank, SLEE, Andrew, TRAINOR, George L., STERN, Andrew M., COPELAND, Robert A., COMBS, Andrew P.

“…The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach…”
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Palladium-catalyzed synthesis of alkynylamino nucleosides. A universal linker for nucleic acids by Hobbs, Frank W

“…A method for attaching alkynylamino "linkers" to nucleosides and nucleosides is described. Protected or unprotected alkynylamines are coupled to…”
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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors by Wityak, John, Hobbs, Frank W., Gardner, Daniel S., Santella, Joseph B., Petraitis, Joseph J., Sun, Jung-Hui, Favata, Margaret F., Daulerio, Andrea J., Horiuchi, Kurumi Y., Copeland, Robert A., Scherle, Peggy A., Jaffe, Bruce D., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Duncia, John V.

“…Employing phenylmalonitrile dianion chemistry, a large number of analogues of MEK inhibitor lead SH053 (IC 50=140 nM) were rapidly synthesized leading to…”
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Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis by Copeland, Robert A., Marcinkeviciene, Jovita, Haque, Tasir S., Kopcho, Lisa M., Jiang, Wenjun, Wang, Kathy, Ecret, Lisa D., Sizemore, Christine, Amsler, Karen A., Foster, Lori, Tadesse, Seifu, Combs, Andrew P., Stern, Andrew M., Trainor, George L., Slee, Andrew, Rogers, M. John, Hobbs, Frank

“…We report the discovery of a class of pyrazole-based compounds that are potent inhibitors of the dihydroorotate dehydrogenase of Helicobacter pylori but that…”
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Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones by Marcinkeviciene, Jovita, Rogers, M.John, Kopcho, Lisa, Jiang, Wenjun, Wang, Kathy, Murphy, Dennis J, Lippy, Jonathan, Link, Steven, Chung, Thomas D.Y, Hobbs, Frank, Haque, Tasir, Trainor, George L, Slee, Andrew, Stern, Andrew M, Copeland, Robert A

“…Dihydroorotate dehydrogenase is a critical enzyme of de novo pyrimidine biosynthesis in prokaryotic and eukaryotic cells. Differences in the primary structure…”
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Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation by Patel, Utpal, Yan, Yong P., Hobbs, Frank W., Kaczmarczyk, Janet, Slee, Andrew M., Pompliano, David L., Kurilla, Michael G., Bobkova, Ekaterina V.

“…Oxazolidinones are potent inhibitors of bacterial protein biosynthesis. Previous studies have demonstrated that this new class of antimicrobial agent blocks…”
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7,8-Dihydro-8-oxoadenine as a replacement for cytosine in the third strand of triple helixes. Triplex formation without hypochromicity by Jetter, Michele C, Hobbs, Frank W

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Synthesis of inositol phosphates by Meek, James L, Davidson, Fred, Hobbs, Frank W

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Improved route to 3-vinyl substituted cyclopentanones. Synthesis of (.+-.)-mitsugashiwalactone by Nugent, William A, Hobbs, Frank W

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A regiospecific, convergent route to 2,3-disubstituted cyclopentanones by Nugent, William A, Hobbs, Frank W

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Synthesis, Structure—Activity Relationships, and In Vivo Evaluation of N3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists by HARTZ, Richard A, AHUJA, Vijay T, HOBBS, Frank W, PAYNE, Joseph, LELAS, Snjezana, LI, Yu-Wen, MOLSKI, Thaddeus F, MATTSON, Gail K, YONG PENG, WONG, Harvey, GRACE, James E, LENTZ, Kimberley A, ARVANITIS, Argyrios G, QIAN-CUTRONE, Jingfang, XIAOLIANG ZHUO, SHU, Yue-Zhong, LODGER, Nicholas J, ZACZEK, Robert, COMBS, Andrew P, OLSON, Richard E, BRONSON, Joanne J, MATTSON, Ronald J, MACOR, John E, RAFALSKI, Maria, YUE, Eddy W, DENHART, Derek J, SCHMITZ, William D, DITTA, Jonathan L, DESKUS, Jeffrey A, BRENNER, Allison B

“…Evidence suggests that corticotropin-releasing factor-1 (CRF(1)) receptor antagonists may offer therapeutic potential for the treatment of diseases associated…”
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Potent Antisense Oligonucleotides to the Human Multidrug Resistance-1 mRNA Are Rationally Selected by Mapping RNA-Accessible Sites With Oligonucleotide Libraries by Peng Ho, Siew, Britton, Dustin H. O., Stone, Barry A., Behrens, Davette L., Leffet, Lynn M., Hobbs, Frank W., Miller, Jeff A., Trainor, George L.

“…Antisense oligonucleotides can vary significantly and unpredictably in their ability to inhibit protein synthesis. Libraries of chimeric oligonucleotides and…”
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Local Medical Committee Elections by Hobbs, Frank E.

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A System for Rapid DNA Sequencing with Fluorescent Chain-Terminating Dideoxynucleotides by Prober, James M., Trainor, George L., Dam, Rudy J., Hobbs, Frank W., Robertson, Charles W., Zagursky, Robert J., Cocuzza, Anthony J., Jensen, Mark A., Baumeister, Kirk

“…A DNA sequencing system based on the use of a novel set of four chain-terminating dideoxynucleotides, each carrying a different chemically tuned…”
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7,8-dihydro-8-oxoadenine as a replacement for cytosine in the third strand of triple helices. Triplex formation without hypochromicity by JETTER, M. C, HOBBS, F. W

“…Oligonucleotides containing thymine and cytosine (or 5-methylcytosine) bases are known to bind to specific homopurine sequences in double-stranded DNA by means…”
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter p ylori Dihydroorotate Dehydrogenase by Haque, Tasir S, Tadesse, Seifu, Marcinkeviciene, Jovita, Rogers, M. John, Sizemore, Christine, Kopcho, Lisa M, Amsler, Karen, Ecret, Lisa D, Zhan, Dong Liang, Hobbs, Frank, Slee, Andrew, Trainor, George L, Stern, Andrew M, Copeland, Robert A, Combs, Andrew P

“…The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach…”
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Unwanted and Mistimed Births in the United States: 1968-1973 by Weller, Robert H., Hobbs, Frank B.

“…Unwanted U.S. marital fertility was down to just nine percent by 1973. The largest proportion of unwanted births was reported by poor black women--23…”
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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products by Duncia, John V., Santella, Joseph B., Higley, C.Anne, Pitts, William J., Wityak, John, Frietze, William E., Rankin, F.Wayne, Sun, Jung-Hui, Earl, Richard A., Tabaka, A.Christine, Teleha, Christopher A., Blom, Karl F., Favata, Margaret F., Manos, Elizabeth J., Daulerio, Andrea J., Stradley, Deborah A., Horiuchi, Kurumi, Copeland, Robert A., Scherle, Peggy A., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Wexler, Ruth R., Hobbs, Frank W., Olson, Richard E.

“…In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive…”
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