Search Results - "Hobbs, Cheryl A."

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin by Hobbs, Cheryl A., Koyanagi, Mihoko, Swartz, Carol, Davis, Jeffrey, Maronpot, Robert, Recio, Leslie, Hayashi, Shim-mo

“…Gardenia blue is widely used in Eastern Asia as a natural food colorant. To evaluate the genotoxic potential of gardenia blue, as well as genipin, the natural…”
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Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin by Hobbs, Cheryl A., Swartz, Carol, Maronpot, Robert, Davis, Jeffrey, Recio, Leslie, Koyanagi, Mihoko, Hayashi, Shim-mo

“…Myricitrin, a flavonoid extracted from the fruit, leaves, and bark of Chinese bayberry (Myrica rubra SIEBOLD), is currently used as a flavor modifier in snack…”
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Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential by Hobbs, Cheryl A., Koyanagi, Mihoko, Swartz, Carol, Davis, Jeffrey, Kasamoto, Sawako, Maronpot, Robert, Recio, Leslie, Hayashi, Shim-mo

“…Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as…”
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JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results by Uno, Yoshifumi, Kojima, Hajime, Omori, Takashi, Corvi, Raffaella, Honma, Masamistu, Schechtman, Leonard M., Tice, Raymond R., Beevers, Carol, Boeck, Marlies De, Burlinson, Brian, Hobbs, Cheryl A., Kitamoto, Sachiko, Kraynak, Andrew R., McNamee, James, Nakagawa, Yuzuki, Pant, Kamala, Plappert-Helbig, Ulla, Priestley, Catherine, Takasawa, Hironao, Wada, Kunio, Wirnitzer, Uta, Asano, Norihide, Escobar, Patricia A., Lovell, David, Morita, Takeshi, Nakajima, Madoka, Ohno, Yasuo, Hayashi, Makoto

“…•JaCVAM organized an international validation study of in vivo rat comet assay.•The ultimate goal was to establish the OECD test guideline.•The assay…”
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Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer by Chepelev, Nikolai L., Gagné, Rémi, Maynor, Timothy, Kuo, Byron, Hobbs, Cheryl A., Recio, Leslie, Yauk, Carole L.

“…Acrylamide (AA) exposure in 2-year cancer bioassays leads to thyroid, but not liver, adenomas and adenocarcinomas in rats. Hypothesized modes of action (MOAs)…”
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Role of pathology peer review in interpretation of the comet assay by Maronpot, Robert R., Hobbs, Cheryl A., Hayashi, Shim-mo

“…When a comet assay, an increasingly popular in vivo genotoxicity test, shows a positive test result, interpretation of that response requires ruling out any…”
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Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential by Hobbs, Cheryl A, Saigo, Kazuhiko, Koyanagi, Mihoko, Hayashi, Shim-Mo

“…Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products,…”
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Comet assay evaluation of six chemicals of known genotoxic potential in rats by Hobbs, Cheryl A., Recio, Leslie, Streicker, Michael, Boyle, Molly H., Tanaka, Jin, Shiga, Atsushi, Witt, Kristine L.

“…•Five genotoxic carcinogens were tested for induction of DNA damage in rats.•Liver and stomach cells of exposed rats were analyzed using the comet assay.•Only…”
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Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues by Recio, Leslie, Kissling, Grace E., Hobbs, Cheryl A., Witt, Kristine L.

“…The National Toxicology Program (NTP) is using the Comet assay to evaluate genotoxic potential, and is investigating the integration of this assay into…”
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Evaluation of the genotoxicity of the food additive, gum ghatti by Hobbs, Cheryl A., Swartz, Carol, Maronpot, Robert, Davis, Jeffrey, Recio, Leslie, Hayashi, Shim-mo

“…► Consumers worldwide could benefit from expanded use of gum ghatti in food products. ► Gum ghatti was tested in a full battery of GLP compliant genotoxicity…”
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Interaction between DNA Polymerase β and BRCA1 by Masaoka, Aya, Gassman, Natalie R, Horton, Julie K, Kedar, Padmini S, Witt, Kristine L, Hobbs, Cheryl A, Kissling, Grace E, Tano, Keizo, Asagoshi, Kenjiro, Wilson, Samuel H

“…The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. Studies of DNA repair functions of BRCA1 have…”
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Genotoxicity assessment of the flavouring agent, perillaldehyde by Hobbs, Cheryl A., Taylor, Sean V., Beevers, Carol, Lloyd, Melvyn, Bowen, Rachael, Lillford, Lucinda, Maronpot, Robert, Hayashi, Shim-mo

“…Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness…”
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Genetic and rat toxicity studies of cyclodextrin glucanotransferase by Maronpot, Robert R, Hobbs, Cheryl A, Davis, Jeffrey, Swartz, Carol, Boyle, Molly, Koyanagi, Mihoko, Hayashi, Shim-Mo

“…Microbiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing agent in manufacture of food, pharmaceuticals, and…”
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Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure by Smith‐Roe, Stephanie L., Wyde, Michael E., Stout, Matthew D., Winters, John W., Hobbs, Cheryl A., Shepard, Kim G., Green, Amanda S., Kissling, Grace E., Shockley, Keith R., Tice, Raymond R., Bucher, John R., Witt, Kristine L.

“…The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2‐year rodent cancer bioassay…”
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Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells by Peshdary, Vian, Hobbs, Cheryl A., Maynor, Timothy, Shepard, Kim, Gagné, Remi, Williams, Andrew, Kuo, Byron, Chepelev, Nikolai, Recio, Leslie, Yauk, Carole, Atlas, Ella

“…Bisphenol A (BPA) is a chemical used in the manufacturing of plastics to which human exposure is ubiquitous. Numerous studies have linked BPA exposure to many…”
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Use of Frozen Tissue in the Comet Assay for the Evaluation of DNA Damage by Hobbs, Cheryl A, Recio, Leslie, Winters, John, Witt, Kristine L

“…The comet assay is gaining popularity as a means to assess DNA damage in cultured cells and tissues, particularly following exposure to chemicals or other…”
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Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice by Hobbs, Cheryl A, Davis, Jeffrey, Shepard, Kim, Chepelev, Nikolai, Friedman, Marvin, Marroni, Dennis, Recio, Leslie

“…Acrylamide is used in many industrial processes and is present in a variety of fried and baked foods. In rodent carcinogenicity assays, acrylamide exposure…”
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Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors by Chepelev, Nikolai L., Gagné, Rémi, Maynor, Timothy, Kuo, Byron, Hobbs, Cheryl A., Recio, Leslie, Yauk, Carole L.

“…Acrylamide (AA) exposure causes increased incidence of forestomach, lung, and Harderian gland tumors in male mice. One hypothesized mode of action (MOA) for…”
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Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells by Cho, Eunnara, Rowan-Carroll, Andrea, Williams, Andrew, Corton, J. Christopher, Li, Heng-Hong, Fornace, Albert J., Hobbs, Cheryl A., Yauk, Carole L.

“…Transcriptomic biomarkers can be used to inform molecular initiating and key events involved in a toxicant’s mode of action. To address the limited approaches…”
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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats by Smith-Roe, Stephanie L., Hobbs, Cheryl A., Hull, Victoria, Todd Auman, J., Recio, Leslie, Streicker, Michael A., Rivas, Miriam V., Pratt, Gabriel A., Lo, Fang Yin, Higgins, Jacob E., Schmidt, Elizabeth K., Williams, Lindsey N., Nachmanson, Daniela, Valentine III, Charles C., Salk, Jesse J., Witt, Kristine L.

“…Duplex sequencing (DS) is an error-corrected next-generation sequencing method in which molecular barcodes informatically link PCR-copies back to their source…”
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