Search Results - "Hobbs, Charlotte A"

An automated 13.5 hour system for scalable diagnosis and acute management guidance for genetic diseases by Owen, Mallory J., Lefebvre, Sebastien, Hansen, Christian, Kunard, Chris M., Dimmock, David P., Smith, Laurie D., Scharer, Gunter, Mardach, Rebecca, Willis, Mary J., Feigenbaum, Annette, Niemi, Anna-Kaisa, Ding, Yan, Van Der Kraan, Luca, Ellsworth, Katarzyna, Guidugli, Lucia, Lajoie, Bryan R., McPhail, Timothy K., Mehtalia, Shyamal S., Chau, Kevin K., Kwon, Yong H., Zhu, Zhanyang, Batalov, Sergey, Chowdhury, Shimul, Rego, Seema, Perry, James, Speziale, Mark, Nespeca, Mark, Wright, Meredith S., Reese, Martin G., De La Vega, Francisco M., Azure, Joe, Frise, Erwin, Rigby, Charlene Son, White, Sandy, Hobbs, Charlotte A., Gilmer, Sheldon, Knight, Gail, Oriol, Albert, Lenberg, Jerica, Nahas, Shareef A., Perofsky, Kate, Kim, Kyu, Carroll, Jeanne, Coufal, Nicole G., Sanford, Erica, Wigby, Kristen, Weir, Jacqueline, Thomson, Vicki S., Fraser, Louise, Lazare, Seka S., Shin, Yoon H., Grunenwald, Haiying, Lee, Richard, Jones, David, Tran, Duke, Gross, Andrew, Daigle, Patrick, Case, Anne, Lue, Marisa, Richardson, James A., Reynders, John, Defay, Thomas, Hall, Kevin P., Veeraraghavan, Narayanan, Kingsmore, Stephen F.

“…While many genetic diseases have effective treatments, they frequently progress rapidly to severe morbidity or mortality if those treatments are not…”
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Diabetes mellitus and birth defects by Correa, Adolfo, MD, PhD, Gilboa, Suzanne M., PhD, Besser, Lilah M., MPH, Botto, Lorenzo D., MD, Moore, Cynthia A., MD, PhD, Hobbs, Charlotte A., MD, PhD, Cleves, Mario A., PhD, Riehle-Colarusso, Tiffany J., MD, Waller, D. Kim, PhD, Reece, E. Albert, MD, PhD, MBA

“…Objective The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects. Study Design This was a multicenter…”
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National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001 by Canfield, Mark A., Honein, Margaret A., Yuskiv, Nataliya, Xing, Jian, Mai, Cara T., Collins, Julianne S., Devine, Owen, Petrini, Joann, Ramadhani, Tunu A., Hobbs, Charlotte A., Kirby, Russell S.

“…BACKGROUND: In the United States, birth defects affect approximately 3% of all births, are a leading cause of infant mortality, and contribute substantially to…”
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Maternal Folate-Related Gene Environment Interactions and Congenital Heart Defects by Hobbs, Charlotte A., Cleves, Mario A., Karim, Mohammad A., Zhao, Weizhi, MacLeod, Stewart L.

“…To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in…”
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Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus–associated birth defects by Correa, Adolfo, MD, PhD, Gilboa, Suzanne M., PhD, Botto, Lorenzo D., MD, Moore, Cynthia A., MD, PhD, Hobbs, Charlotte A., MD, PhD, Cleves, Mario A., PhD, Riehle-Colarusso, Tiffany J., MD, Waller, D. Kim, PhD, Reece, E. Albert, MD, PhD, MBA

“…Objective The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins…”
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Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach by Patel, Jenil, Bircan, Emine, Tang, Xinyu, Orloff, Mohammed, Hobbs, Charlotte A, Browne, Marilyn L, Botto, Lorenzo D, Finnell, Richard H, Jenkins, Mary M, Olshan, Andrew, Romitti, Paul A, Shaw, Gary M, Werler, Martha M, Li, Jingyun, Nembhard, Wendy N

“…Previous research on risk factors for obstructive heart defects (OHDs) focused on maternal and infant genetic variants, prenatal environmental exposures, and…”
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Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects by Allen, Emily Graves, Freeman, Sallie B., Druschel, Charlotte, Hobbs, Charlotte A., O’Leary, Leslie A., Romitti, Paul A., Royle, Marjorie H., Torfs, Claudine P., Sherman, Stephanie L.

“…We examined the association between maternal age and chromosome 21 nondisjunction by origin of the meiotic error. We analyzed data from two population-based,…”
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Maternal genome-wide DNA methylation patterns and congenital heart defects by Chowdhury, Shimul, Erickson, Stephen W, MacLeod, Stewart L, Cleves, Mario A, Hu, Ping, Karim, Mohammad A, Hobbs, Charlotte A

“…The majority of congenital heart defects (CHDs) are thought to result from the interaction between multiple genetic, epigenetic, environmental, and lifestyle…”
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Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project by Freeman, Sallie B., Bean, Lora H., Allen, Emily G., Tinker, Stuart W., Locke, Adam E., Druschel, Charlotte, Hobbs, Charlotte A., Romitti, Paul A., Royle, Marjorie H., Torfs, Claudine P., Dooley, Kenneth J., Sherman, Stephanie L.

“…The population-based National Down Syndrome Project combined epidemiological and molecular methods to study congenital heart defects in Down syndrome. Between…”
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Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study by Webber, Daniel M, Li, Ming, MacLeod, Stewart L, Tang, Xinyu, Levy, Joseph W, Karim, Mohammad A, Erickson, Stephen W, Hobbs, Charlotte A, The National Birth Defects Prevention Study

“…Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality…”
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Association between prepregnancy body mass index and congenital heart defects by Gilboa, Suzanne M., PhD, Correa, Adolfo, MD, PhD, Botto, Lorenzo D., MD, Rasmussen, Sonja A., MD, MS, Waller, D. Kim, PhD, Hobbs, Charlotte A., MD, PhD, Cleves, Mario A., PhD, Riehle-Colarusso, Tiffany J., MD, MSE

“…Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design…”
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Association Between Congenital Heart Defects and Small for Gestational Age by Malik, Sadia, Cleves, Mario A, Zhao, Weizhi, Correa, Adolfo, Hobbs, Charlotte A, and National Birth Defects Prevention Study

“…Infants with congenital heart defects may experience inhibited growth during fetal life. In a large case-control study, we addressed the hypothesis that…”
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Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study by Mac Bird, T, Robbins, James M, Druschel, Charlotte, Cleves, Mario A, Yang, Shengping, Hobbs, Charlotte A

“…Abstract Background Primary prevention efforts for both gastroschisis and omphalocele are limited by the lack of known risk factors. Our objective was to…”
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Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism by Hobbs, C.A, Cleves, M.A, Melnyk, S, Zhao, W, James, S.J

“…Background: It is well established that folic acid prevents neural tube defects. Although the mechanisms remain unclear, multivitamins containing folic acid…”
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Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use by Tang, Xinyu, Hobbs, Charlotte A., Cleves, Mario A., Erickson, Stephen W., MacLeod, Stewart L., Malik, Sadia

“…Background Congenital heart defects (CHDs) are among the most prevalent and serious birth defects, occurring in 8 to 10 of every 1000 live births in the United…”
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Maternal obesity and tobacco use modify the impact of genetic variants on the occurrence of conotruncal heart defects by Tang, Xinyu, Nick, Todd G, Cleves, Mario A, Erickson, Stephen W, Li, Ming, Li, Jingyun, MacLeod, Stewart L, Hobbs, Charlotte A

“…Conotruncal heart defects (CTDs) are among the most severe birth defects worldwide. Studies of CTDs indicate both lifestyle behaviors and genetic variation…”
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Associations between maternal genotypes and metabolites implicated in congenital heart defects by Chowdhury, Shimul, Hobbs, Charlotte A., MacLeod, Stewart L., Cleves, Mario A., Melnyk, Stepan, James, S. Jill, Hu, Ping, Erickson, Stephen W.

“…The development of non-syndromic congenital heart defects (CHDs) involves a complex interplay of genetics, metabolism, and lifestyle. Previous studies have…”
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Gene‐by‐gene interactions associated with the risk of conotruncal heart defects by Lyu, Chen, Webber, Daniel M., MacLeod, Stewart L., Hobbs, Charlotte A., Li, Ming

“…Background The development of conotruncal heart defects (CTDs) involves a complex relationship among genetic variants and maternal lifestyle factors. In this…”
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Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission by Karthikeyan, Smruthi, Levy, Joshua I., De Hoff, Peter, Humphrey, Greg, Birmingham, Amanda, Jepsen, Kristen, Farmer, Sawyer, Tubb, Helena M., Valles, Tommy, Tribelhorn, Caitlin E., Tsai, Rebecca, Aigner, Stefan, Moshiri, Niema, Henson, Benjamin, Mark, Adam M., Hakim, Abbas, Baer, Nathan A., Barber, Tom, Belda-Ferre, Pedro, Chacón, Marisol, Cresini, Evelyn S., Eisner, Emily R., Lastrella, Alma L., Lawrence, Elijah S., Marotz, Clarisse A., Ngo, Toan T., Ostrander, Tyler, Plascencia, Ashley, Salido, Rodolfo A., Seaver, Phoebe, Smoot, Elizabeth W., McDonald, Daniel, Neuhard, Robert M., Scioscia, Angela L., Satterlund, Alysson M., Simmons, Elizabeth H., Abelman, Dismas B., Brenner, David, Buckley, Anne, Gattas, Jeffrey, Gonias, Steven L., Hale, Matt, Ikeda, Lydia, Jhaveri, Hemlata, Kremer, Brendan, McLawhon, Ronald W., Ouillet, Pierre, Park, Daniel, Pradenas, Allorah, Riggs, Lindsay, Sanders, Alison, Sollenberger, Bradley, White, Benjamin, Winbush, Terri, Aceves, Christine M., Anderson, Catelyn, Gangavarapu, Karthik, Hufbauer, Emory, Kurzban, Ezra, Lee, Justin, Matteson, Nathaniel L., Parker, Edyth, Perkins, Sarah A., Ramesh, Karthik S., Schwab, Madison A., Wohl, Shirlee, Nicholson, Laura, McHardy, Ian H., Hobbs, Charlotte A., Bakhtar, Omid, Mendoza, Art, Becker, David, Cirulli, Elizabeth T., Isaksson, Magnus, Schiabor Barrett, Kelly M., Washington, Nicole L., Malone, John D., Schafer, Ashleigh Murphy, Fielding-Miller, Rebecca, Garfein, Richard S., Gaines, Tommi, Anderson, Cheryl, Martin, Natasha K., Schooley, Robert, Austin, Brett, Kingsmore, Stephen F., Lee, William, Shah, Seema, McDonald, Eric, Yu, Alexander T., Zeller, Mark, Fisch, Kathleen M., Longhurst, Christopher, Maysent, Patty, Pride, David, Khosla, Pradeep K., Laurent, Louise C., Yeo, Gene W., Andersen, Kristian G., Knight, Rob

“…As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by…”
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One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects by Shaw, Gary M., Yang, Wei, Carmichael, Suzan L., Vollset, Stein Emil, Hobbs, Charlotte A., Lammer, Edward J., Ueland, Per M.

“…Background Evidence exists for an association between use of vitamin supplements with folic acid in early pregnancy and reduced risk for offspring with…”
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