Search Results - "Hoag, Matthew R."

Fc-competent multispecific PDL-1/TIGIT/LAG-3 antibodies potentiate superior anti-tumor T cell response by Yang, Riyao, Huang, Su, Huang, Cai, Fay, Nathan S., Wang, Yanan, Putrevu, Saroja, Wright, Kimberly, Zaman, Mohd Saif, Cai, Wenyan, Huang, Betty, Wang, Bo, Wright, Meredith, Hoag, Matthew R., Titong, Allison, Liu, Yue

“…The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their…”
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Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form by Alt, Tyler B, Hoag, Matthew R, Moran, Graham R

“…Dihydropyrimidine dehydrogenase (DPD) is an enzyme that uses an elaborate architecture to catalyze a simple net reaction: the reduction of the vinylic bond of…”
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The enzyme: Renalase by Moran, Graham R., Hoag, Matthew R.

“…Within the last two years catalytic substrates for renalase have been identified, some 10 years after its initial discovery. 2- and 6-dihydronicotinamide (2-…”
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Renalase does not catalyze the oxidation of catecholamines by Beaupre, Brett A., Hoag, Matthew R., Moran, Graham R.

“…•The catecholamine oxidase activity claim for renalase was based on flawed methods.•The majority of renalase research has assumed catecholamine oxidase…”
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Renalase Is an α‑NAD(P)H Oxidase/Anomerase by Beaupre, Brett A, Carmichael, Brenton R, Hoag, Matthew R, Shah, Dhara D, Moran, Graham R

“…Renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure and slow heart rate. Since its discovery in 2005,…”
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PvdF of pyoverdin biosynthesis is a structurally unique N 10 -formyltetrahydrofolate-dependent formyltransferase by Kenjić, Nikola, Hoag, Matthew R, Moraski, Garrett C, Caperelli, Carol A, Moran, Graham R, Lamb, Audrey L

“…The hydroxyornithine transformylase from Pseudomonas aeruginosa is known by the gene name pvdF, and has been hypothesized to use N -formyltetrahydrofolate (N…”
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Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6‑Dihydro-β-NAD(P) Oxidase Activity from Pseudomonas phaseolicola by Hoag, Matthew R, Roman, Joseph, Beaupre, Brett A, Silvaggi, Nicholas R, Moran, Graham R

“…Despite a lack of convincing in vitro evidence and a number of sound refutations, it is widely accepted that renalase is an enzyme unique to animals that…”
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PvdF of pyoverdin biosynthesis is a structurally unique N10-formyltetrahydrofolate-dependent formyltransferase by Kenjić, Nikola, Hoag, Matthew R., Moraski, Garrett C., Caperelli, Carol A., Moran, Graham R., Lamb, Audrey L.

“…The hydroxyornithine transformylase from Pseudomonas aeruginosa is known by the gene name pvdF, and has been hypothesized to use N10-formyltetrahydrofolate…”
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A novel IgG Fc by computer-aided design enhances heavy-chain heterodimerization in bi- or trispecific antibodies by Wang, Bo, Lin, Jun, Hoag, Matthew R, Wright, Meredith, Ma, Mingjun, Cai, Wenyan, Gallolu Kankanamalage, Sachith, Liu, Yue

“…Abstract The classical `knob-into-holes' (KIH) strategy (knob(T366Y)/hole (Y407T)) has successfully enhanced the heterodimerization of a bispecific antibody…”
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Kinetics and Equilibria of the Reductive and Oxidative Half-Reactions of Human Renalase with α‑NADPH by Beaupre, Brett A, Hoag, Matthew R, Carmichael, Brenton R, Moran, Graham R

“…Renalase is a recently discovered flavoprotein that has been reported to be a hormone produced by the kidney to down-modulate blood pressure and heart rate…”
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Ligand binding phenomena that pertain to the metabolic function of renalase by Beaupre, Brett A., Roman, Joseph V., Hoag, Matthew R., Meneely, Kathleen M., Silvaggi, Nicholas R., Lamb, Audrey L., Moran, Graham R.

“…Renalase catalyzes the oxidation of isomers of β-NAD(P)H that carry the hydride in the 2 or 6 positions of the nicotinamide base to form β-NAD(P)+. This…”
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Dihydropyrimidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form by Alt, Tyler B., Hoag, Matthew R., Moran, Graham R.

“…Dihydropyrimidine dehydrogenase (DPD) is an enzyme that uses an elaborate architecture to catalyze a simple net reaction: the reduction of the vinylic bond of…”
Get full text