Search Results - "Hoadley, Margaret"

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study by Galea, James, Ogungbenro, Kayode, Hulme, Sharon, Patel, Hiren, Scarth, Sylvia, Hoadley, Margaret, Illingworth, Karen, McMahon, Catherine J, Tzerakis, Nikolaos, King, Andrew T, Vail, Andy, Hopkins, Stephen J, Rothwell, Nancy, Tyrrell, Pippa

“…OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the…”
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The role of cortisol in immunosuppression in subarachnoid haemorrhage by Hoadley, Margaret E, Galea, James, Singh, Navneet, Hulme, Sharon, Ajao, David O, Rothwell, Nancy, King, Andrew, Tyrrell, Pippa, Hopkins, Stephen J

“…Background We sought to determine the extent to which cortisol suppressed innate and T cell-mediated cytokine production and whether it could be involved in…”
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Does previous stroke modify the relationship between inflammatory biomarkers and clinical endpoints in CKD patients? by Tollitt, James, Allan, Stuart M, Chinnadurai, Rajkumar, Odudu, Aghogho, Hoadley, Margaret, Smith, Craig, Kalra, Philip A

“…Chronic kidney disease (CKD) is an independent risk factor for stroke. Stroke is also an independent risk factor for worse CKD outcomes and inflammation may…”
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Overcoming matrix matching problems in multiplex cytokine assays by Hoadley, Margaret E., Hopkins, Stephen J.

“…Failure to match assay matrices with samples in immunoassays can result in incorrect sample values being reported. For multiplex assays this presents…”
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Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection by Hopkins, Stephen J, McMahon, Catherine J, Singh, Navneet, Galea, James, Hoadley, Margaret, Scarth, Sylvia, Patel, Hiren, Vail, Andy, Hulme, Sharon, Rothwell, Nancy J, King, Andrew T, Tyrrell, Pippa J

“…Cytokines and cytokine receptor concentrations increase in plasma and cerebrospinal fluid (CSF) of patients following subarachnoid haemorrhage (SAH). The…”
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Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression by Smith, Craig J., Emsley, Hedley C., Udeh, Chinedu T., Vail, Andy, Hoadley, Margaret E., Rothwell, Nancy J., Tyrrell, Pippa J., Hopkins, Stephen J.

“…► Infections complicating stroke are common and adversely affect outcome. ► Cellular immune suppression may enhance susceptibility to such infections. ► We…”
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Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production by Emsley, Hedley C A, Smith, Craig J, Gavin, Carole M, Georgiou, Rachel F, Vail, Andy, Barberan, Elisa M, Illingworth, Karen, Scarth, Sylvia, Wickramasinghe, Vijitha, Hoadley, Margaret E, Rothwell, Nancy J, Tyrrell, Pippa J, Hopkins, Stephen J

“…As critical mediators of local and systemic inflammatory responses, cytokines are produced in the brain following ischaemic stroke. Some have been detected in…”
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Reconstituting National Institute for Biological Standards and Control (NIBSC) chemokines by Hoadley, Margaret E., Scarth, Sylvia, Hopkins, Stephen J.

“…► Preparation of IL-8 and MCP-1 standards can result in loss of immunoreactivity. ► Even brief addition of water to these chemokines resulted in loss of…”
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Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge by Linthorst, Astrid C. E, Flachskamm, Cornelia, Hopkins, Stephen J, Hoadley, Margaret E, Labeur, MartaS, Holsboer, Florian, Reul, Johannes M. H. M

“…Corticotropin-releasing hormone (CRH) was infused intracerebroventricularly into rats for 7 d via a miniosmotic pump (1 microg . microl-1 . hr-1). Body…”
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Comparison of ‘real-time’ and immunometric RT-PCR: RNA interference of reverse transcriptase-PCR by Hoadley, Margaret E., Hopkins, Stephen J.

“…We measured interleukin-6 (IL-6) mRNA in whole blood, using an immunometric reverse transcriptase-polymerase chain reaction (IRT-PCR) method and ‘real-time’…”
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SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial by Smith, Craig J, Hulme, Sharon, Vail, Andy, Heal, Calvin, Parry-Jones, Adrian R, Scarth, Sylvia, Hopkins, Karen, Hoadley, Margaret, Allan, Stuart M, Rothwell, Nancy J, Hopkins, Stephen J, Tyrrell, Pippa J

“…BACKGROUND AND PURPOSE—The proinflammatory cytokine IL-1 (interleukin-1) has a deleterious role in cerebral ischemia, which is attenuated by IL-1 receptor…”
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Simple, quantitative measurement of cytokine gene expression using an immunometric reverse transcriptase-polymerase chain reaction by Hoadley, Margaret E., Hopkins, Stephen J.

“…We have developed a novel system to quantify mRNA, using a coupled reverse transcriptase-polymerase chain reaction (RT-PCR) with RNA standards and an…”
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The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial by Singh, Navneet, Hopkins, Stephen J, Hulme, Sharon, Galea, James P, Hoadley, Margaret, Vail, Andy, Hutchinson, Peter J, Grainger, Samantha, Rothwell, Nancy J, King, Andrew T, Tyrrell, Pippa J

“…Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits…”
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Fever and production of cytokines in response to repeated injections of muramyl dipeptide in guinea-pigs by Roth, J, Hopkins, S J, Hoadley, M E, Tripp, A, Aslan, T, Störr, B, Luheshi, G N, Zeisberger, E

“…Fever and systemic plasma levels of the cytokines tumour necrosis factor alpha (TNF) and interleukin-6 (IL-6) were measured in guinea-pigs in response to…”
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Growth and Drug Uptake Characteristics of Some Aminoglycoside Phenotypes of Escherichia coli by Hoadley, Margaret Elizabeth

“…In this project strains of Escherichia coli (Watts) sensitive to, resistant to and dependent upon aminoglycoside antibiotics were characterized according to…”
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A simple assay system incorporating monoclonal antibodies for the detection of potato virus T by Vernon Shirley M.L, Burns R, George E.L, Hoadley M.E

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