Search Results - "Hoad, C L"

Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea‐predominant irritable bowel syndrome measured using serial MRI by Pritchard, S. E., Marciani, L., Garsed, K. C., Hoad, C. L., Thongborisute, W., Roberts, E., Gowland, P. A., Spiller, R. C.

“…Background Previous assessments of colon morphology have relied on tests which were either invasive or used ionizing radiation. We aimed to measure regional…”
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Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights by Marciani, L, Pritchard, S E, Hellier-Woods, C, Costigan, C, Hoad, C L, Gowland, P A, Spiller, R C

“…Background/Objectives: Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often…”
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Measurement of gastric meal and secretion volumes using magnetic resonance imaging by Hoad, C L, Parker, H, Hudders, N, Costigan, C, Cox, E F, Perkins, A C, Blackshaw, P E, Marciani, L, Spiller, R C, Fox, M R, Gowland, P A

“…MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus…”
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Effects of various food ingredients on gall bladder emptying by Marciani, L, Cox, E F, Hoad, C L, Totman, J J, Costigan, C, Singh, G, Shepherd, V, Chalkley, L, Robinson, M, Ison, R, Gowland, P A, Spiller, R C

“…Background/objectives: The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in…”
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Colon wall motility: comparison of novel quantitative semi‐automatic measurements using cine MRI by Hoad, C. L., Menys, A., Garsed, K., Marciani, L., Hamy, V., Murray, K., Costigan, C., Atkinson, D., Major, G., Spiller, R. C., Taylor, S. A., Gowland, P. A.

“…Background Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been…”
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Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose by Marciani, L., Garsed, K. C., Hoad, C. L., Fields, A., Fordham, I., Pritchard, S. E., Placidi, E., Murray, K., Chaddock, G., Costigan, C., Lam, C., Jalanka‐Tuovinen, J., De Vos, W. M., Gowland, P. A., Spiller, R. C.

“…Background Most methods of assessing colonic motility are poorly acceptable to patients. Magnetic resonance imaging (MRI) can monitor gastrointestinal motility…”
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Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects by Chaddock, G., Lam, C., Hoad, C. L., Costigan, C., Cox, E. F., Placidi, E., Thexton, I., Wright, J., Blackshaw, P. E., Perkins, A. C., Marciani, L., Gowland, P. A., Spiller, R. C.

“…Background Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation…”
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Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non‐invasive imaging by Parker, H. L., Tucker, E., Hoad, C. L., Pal, A., Costigan, C., Hudders, N., Perkins, A., Blackshaw, E., Gowland, P., Marciani, L., Fox, M. R.

“…Background Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely…”
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The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea by Placidi, E., Marciani, L., Hoad, C. L., Napolitano, A., Garsed, K. C., Pritchard, S. E., Cox, E. F., Costigan, C., Spiller, R. C., Gowland, P. A.

“…Summary Background Loperamide (LOP) is an anti‐diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid…”
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Effect of experimental stress on the small bowel and colon in healthy humans by Pritchard, S. E., Garsed, K. C., Hoad, C. L., Lingaya, M., Banwait, R., Thongborisute, W., Roberts, E., Costigan, C., Marciani, L., Gowland, P. A., Spiller, R. C.

“…Background Symptoms of irritable bowel syndrome (IBS) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing…”
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Effects of a 5‐HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging by Marciani, L., Wright, J., Foley, S., Hoad, C. L., Totman, J. J., Bush, D., Hartley, C., Armstrong, A., Manby, P., Blackshaw, E., Perkins, A. C., Gowland, P. A., Spiller, R. C.

“…Aliment Pharmacol Ther 2010; 32: 655–663 Summary Background  5‐HT3 antagonists have been shown to be effective in relieving the symptoms of irritable bowel…”
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Segmentation of MR images for computer-assisted surgery of the lumbar spine by Hoad, C L, Martel, A L

“…This paper describes a segmentation algorithm designed to separate bone from soft tissue in magnetic resonance (MR) images developed for computer-assisted…”
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Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging by Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos‐Santiago, A., Kurtz, C. B., Johnston, J. M., Gowland, P., Spiller, R.

“…Background In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the…”
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Assessment of motion of colonic contents in the human colon using MRI tagging by Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., Hoad, C. L.

“…Background We have previously reported a non‐invasive, semi‐automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic…”
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Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects by Parker, H. L., Tucker, E., Blackshaw, E., Hoad, C. L., Marciani, L., Perkins, A., Menne, D., Fox, M.

“…Background Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely…”
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Characterization of the time course of the superior mesenteric, abdominal aorta, internal carotid and vertebral arteries blood flow response to the oral glucose challenge test using magnetic resonance imaging by Totman, J J, Marciani, L, Foley, S, Campbell, E, Hoad, C L, Macdonald, I A, Spiller, R C, Gowland, P A

“…Blood flow to the splanchnic circulation increases postprandially which may cause a reduction in systemic and cerebral perfusion leading to postprandial…”
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MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans by Khalaf, A., Hoad, C. L., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., Lingaya, M., Falcone, Y., Singh, G., Spiller, R. C., Gowland, P. A., Marciani, L., Moran, G. W.

“…Background Feeding triggers inter‐related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological…”
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Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans by Marciani, L, Cox, E F, Pritchard, S E, Major, G, Hoad, C L, Mellows, M, Hussein, M O, Costigan, C, Fox, M, Gowland, P A, Spiller, R C

“…Background/Objectives: Intake of food or fluid distends the stomach and triggers mechanoreceptors and vagal afferents. Wall stretch and tension produces a…”
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A 3D MRI sequence for computer assisted surgery of the lumbar spine by Hoad, C L, Martel, A L, Kerslake, R, Grevitt, M

“…The aim of this research was to develop a magnetic resonance (MR) sequence capable of producing images suitable for use with computer assisted surgery (CAS) of…”
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Non-invasive quantification of small bowel water content by MRI: a validation study by Hoad, C L, Marciani, L, Foley, S, Totman, J J, Wright, J, Bush, D, Cox, E F, Campbell, E, Spiller, R C, Gowland, P A

“…Substantial water fluxes across the small intestine occur during digestion of food, but so far measuring these has required invasive intubation techniques…”
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