Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal–Human Interface in Vietnam, 2003–2010

Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the animal–human interface remain a major concern for emergence of viruses with pandemic potential. To understand the relationship of H5N1 viruses circulating in poultry and those isolated from humans, comprehensive ph...

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Published in:	The Journal of infectious diseases Vol. 216; no. suppl_4; pp. S529 - S538
Main Authors:	Creanga, Adrian, Le Khanh Hang, Nguyen, Cuong, Vuong Duc, Nguyen, Ha T., Phuong, Hoang Vu Mai, Le Thi Thanh, Thach, Nguyen Co, Hien, Pham Thi, Tung, Nguyen, Jang, Yunho, Balish, Amanda, Dang, Nguyen Hoang, Duong, Mai Thuy, Huong, Ngo Thu, Hoa, Do Ngoc, Tho, Nguyen Dang, Klimov, Alexander, Kapella, Bryan K., Gubareva, Larisa, Kile, James C., Hien, Nguyen Tran, Le Quynh Mai, Davis, C. Todd
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 15-09-2017
Subjects:	Amino Acid Sequence Animals Drug Resistance, Multiple, Viral Genotype Genotyping Techniques Humans Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza in Birds - drug therapy Influenza in Birds - epidemiology Influenza in Birds - transmission Influenza, Human - drug therapy Influenza, Human - epidemiology Pandemics Phylogeny Poultry - virology RNA, Viral - genetics Sequence Analysis, RNA Spatio-Temporal Analysis SUPPLEMENT ARTICLES Vietnam - epidemiology Viral Proteins - genetics phylogenetics Vietnam highly pathogenic avian influenza A(H5N1) virus Orthomyxovirus evolution
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Summary:	Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the animal–human interface remain a major concern for emergence of viruses with pandemic potential. To understand the relationship of H5N1 viruses circulating in poultry and those isolated from humans, comprehensive phylogenetic and molecular analyses of viruses collected from both hosts in Vietnam between 2003 and 2010 were performed. We examined the temporal and spatial distribution of human cases relative to H5N1 poultry outbreaks and characterized the genetic lineages and amino acid substitutions in each gene segment identified in humans relative to closely related viruses from avian hosts. Six hemagglutinin clades and 8 genotypes were identified in humans, all of which were initially identified in poultry. Several amino acid mutations throughout the genomes of viruses isolated from humans were identified, indicating the potential for poultry viruses infecting humans to rapidly acquire molecular markers associated with mammalian adaptation and antiviral resistance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jix003