Search Results - "Ho‐Mok, Kam"

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype by Vaz, Frédéric M., Paulusma, Coen C., Huidekoper, Hidde, de Ru, Minke, Lim, Cynthia, Koster, Janet, Ho‐Mok, Kam, Bootsma, Albert H., Groen, Albert K., Schaap, Frank G., Oude Elferink, Ronald P. J., Waterham, Hans R., Wanders, Ronald J.A.

“…The enterohepatic circulation of bile salts is an important physiological route to recycle bile salts and ensure intestinal absorption of dietary lipids. The…”
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The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages by Gómez‐Mellado, Valentina E., Ho‐Mok, Kam S., Mark, Vincent A., Wel, Nicole N., Grootemaat, Anita E., Verhoeven, Arthur J., Elferink, Ronald P. J. Oude, Paulusma, Coen C.

“…ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of…”
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Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport by Paulusma, Coen C., Groen, Annemiek, Kunne, Cindy, Ho‐Mok, Kam S., Spijkerboer, Astrid L., Rudi de Waart, D., Hoek, Frans J., Vreeling, Heleen, Hoeben, Kees A., van Marle, Jan, Pawlikowska, Ludmila, Bull, Laura N., Hofmann, Alan F., Knisely, A. S., Oude Elferink, Ronald P. J.

“…Progressive familial intrahepatic cholestasis type 1 (PFIC1, Byler disease, OMIM 211600) is a severe inherited liver disease caused by mutations in ATP8B1…”
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ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes by de Waart, Dirk R., Naik, Jyoti, Utsunomiya, Karina S., Duijst, Suzanne, Ho‐Mok, Kam, Bolier, A. Ruth, Hiralall, Johan, Bull, Laura N., Bosma, Piter J., Oude Elferink, Ronald P.J., Paulusma, Coen C.

“…ATP11C is a homolog of ATP8B1, both of which catalyze the transport of phospholipids in biological membranes. Mutations in ATP8B1 cause progressive familial…”
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Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1 by Folmer, Dineke E., van der Mark, Vincent A., Ho‐Mok, Kam S., Oude Elferink, Ronald P.J., Paulusma, Coen C.

“…Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1 (BRIC1), forming a…”
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ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells by Gómez-Mellado, Valentina E., Chang, Jung-Chin, Ho-Mok, Kam S., Bernardino Morcillo, Carmen, Kersten, Remco H. J., Oude Elferink, Ronald P. J., Verhoeven, Arthur J., Paulusma, Coen C.

“…ATP8B1 is a phospholipid flippase that is deficient in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1). PFIC1 patients suffer from…”
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Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 by van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Oude Elferink, Ronald P. J., Paulusma, Coen C.

“…P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of…”
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ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity by Paulusma, Coen C., Folmer, Dineke E., Ho‐Mok, Kam S., de Waart, D. Rudi, Hilarius, Petra M., Verhoeven, Arthur J., Oude Elferink, Ronald P. J.

“…Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1. Previously, we have shown…”
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The lipid flippase heterodimer ATP8B1–CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells by van der Mark, Vincent A., de Waart, D. Rudi, Ho-Mok, Kam S., Tabbers, Merit M., Voogt, Heleen W., Oude Elferink, Ronald P.J., Knisely, A.S., Paulusma, Coen C.

“…Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic…”
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The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function by Koelink, Pim J, Gómez-Mellado, Valentina E, Duijst, Suzanne, van Roest, Manon, Meisner, Sander, Ho-Mok, Kam S, Frank, Sabrina, Appelman, Babette S, Bloemendaal, Lysbeth Ten, Vogel, Georg F, van de Graaf, Stan F J, Bosma, Piter J, Oude Elferink, Ronald P J, Wildenberg, Manon E, Paulusma, Coen C

“…Patients with mutations in ATP8B1 develop progressive familial intrahepatic cholestasis type 1 [PFIC1], a severe liver disease that requires life-saving liver…”
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The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator by van der Mark, Vincent A., de Jonge, Hugo R., Chang, Jung-Chin, Ho-Mok, Kam S., Duijst, Suzanne, Vidović, Dragana, Carlon, Marianne S., Oude Elferink, Ronald P.J., Paulusma, Coen C.

“…Progressive familial intrahepatic cholestasis type 1 (PFIC1) is caused by mutations in the gene encoding the phospholipid flippase ATP8B1. Apart from severe…”
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Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 by van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Elferink, Ronald P. J. Oude, Paulusma, Coen C.

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ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function by Naik, Jyoti, de Waart, Dirk R, Utsunomiya, Karina, Duijst, Suzanne, Mok, Kam Ho, Oude Elferink, Ronald P J, Bosma, Piter J, Paulusma, Coen C

“…P4 ATPases are lipid flippases and transport phospholipids from the exoplasmic to the cytosolic leaflet of biological membranes. Lipid flipping is important…”
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