Search Results - "Hołówka, Joanna"
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Lsr2, a nucleoid-associated protein influencing mycobacterial cell cycle
Published in Scientific reports (03-02-2021)“…Nucleoid-associated proteins (NAPs) are responsible for maintaining highly organized and yet dynamic chromosome structure in bacteria. The genus Mycobacterium…”
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The Origin of Chromosomal Replication Is Asymmetrically Positioned on the Mycobacterial Nucleoid, and the Timing of Its Firing Depends on HupB
Published in Journal of bacteriology (15-05-2018)“…The bacterial chromosome undergoes dynamic changes in response to ongoing cellular processes and adaptation to environmental conditions. Among the many…”
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HupB Is a Bacterial Nucleoid-Associated Protein with an Indispensable Eukaryotic-Like Tail
Published in mBio (07-11-2017)“…In bacteria, chromosomal DNA must be efficiently compacted to fit inside the small cell compartment while remaining available for the proteins involved in…”
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Mycobacterial IHF is a highly dynamic nucleoid-associated protein that assists HupB in organizing chromatin
Published in Frontiers in microbiology (07-03-2023)“…Nucleoid-associated proteins (NAPs) crucially contribute to organizing bacterial chromatin and regulating gene expression. Among the most highly expressed NAPs…”
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Choreography of the Mycobacterium replication machinery during the cell cycle
Published in mBio (17-02-2015)“…It has recently been demonstrated that bacterial chromosomes are highly organized, with specific positioning of the replication initiation region. Moreover,…”
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Lsr2 and Its Novel Paralogue Mediate the Adjustment of Mycobacterium smegmatis to Unfavorable Environmental Conditions
Published in mSphere (12-05-2021)“…Lsr2 is a nucleoid-associated protein (NAP) that has been found strictly in actinobacteria, including mycobacteria. It is a functional homolog of histone-like…”
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Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress
Published in Frontiers in microbiology (08-04-2020)“…The bacterial chromosome must be efficiently compacted to fit inside the small and crowded cell while remaining accessible for the protein complexes involved…”
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MksB is a novel mycobacterial condensin that orchestrates spatiotemporal positioning of replication machinery
Published in Scientific reports (16-08-2024)“…Condensins play important roles in maintaining bacterial chromatin integrity. In mycobacteria, three types of condensins have been characterized: a homolog of…”
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Watching DNA Replication Inhibitors in Action: Exploiting Time-Lapse Microfluidic Microscopy as a Tool for Target-Drug Interaction Studies in Mycobacterium
Published in Antimicrobial agents and chemotherapy (01-10-2019)“…Spreading resistance to antibiotics and the emergence of multidrug-resistant strains have become frequent in many bacterial species, including mycobacteria,…”
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Where and When Bacterial Chromosome Replication Starts: A Single Cell Perspective
Published in Frontiers in microbiology (26-11-2018)“…Bacterial chromosomes have a single, unique replication origin (named ), from which DNA synthesis starts. This study describes methods of visualizing regions…”
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Multifork chromosome replication in slow-growing bacteria
Published in Scientific reports (06-03-2017)“…The growth rates of bacteria must be coordinated with major cell cycle events, including chromosome replication. When the doubling time (Td) is shorter than…”
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Structure of bacterial chromosome: An analysis of DNA-protein interactions in vivo
Published in Postȩpy higieny i medycyny doświadczalnej (08-12-2017)“…According to recent reports, bacterial chromosomes exhibit a hierarchical organization. The number of proteins that bind DNA are responsible for local and…”
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Searching for new antibiotics--inhibitors of bacterial chromosome replication
Published in Postȩpy higieny i medycyny doświadczalnej (03-06-2014)“…The excessive and often unreasonable use of antibacterial drugs leads to rise of antibioticresistant strains. To overcome this problem, new antibiotics are…”
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Searching for new antibiotics--inhibitors of bacterial chromosome replication
Published in Postȩpy higieny i medycyny doświadczalnej (03-06-2014)Get full text
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