Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics

Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics

The increasing number of coronavirus disease 2019 (COVID-19) cases in the community has posed a significant epidemic pressure on healthcare settings. When healthcare workers (HCWs) acquire COVID-19, contact tracing and epidemiological investigation might not be adequate for determining the source of...

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Bibliographic Details
Published in:The Journal of hospital infection Vol. 115; pp. 59 - 63
Main Authors: Wong, R.C.W., Lee, M.K.P., Siu, G.K.H., Lee, L.K., Leung, J.S.L., Leung, E.C.M., Ho, Y.I.I., Lai, R.W.M.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-09-2021
The Healthcare Infection Society. Published by Elsevier Ltd
Subjects:
COVID-19
Disease Outbreaks
Epidemiology
Health Personnel
Healthcare workers
Humans
Phylogenomics
Phylogeny
SARS-CoV-2
Short Report
Whole-genome sequencing
COVID-19
SARS-CoV-2
Healthcare workers
Whole-genome sequencing
Epidemiology
Phylogenomics
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Summary:The increasing number of coronavirus disease 2019 (COVID-19) cases in the community has posed a significant epidemic pressure on healthcare settings. When healthcare workers (HCWs) acquire COVID-19, contact tracing and epidemiological investigation might not be adequate for determining the source of transmission. Here, we report a phylogenetic investigation involving two infected HCWs and nine patients to determine whether patient-to-HCW transmission had occurred in a hospital without a previous COVID-19 outbreak. This is the first study to apply phylogenomics to investigate suspected nosocomial transmission in a region with low prevalence of COVID-19. Our results do not support the occurrence of direct patient-to-HCW transmission.
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ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2021.05.017