Search Results - "Ho, Y. T. Candace"

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity by Izoré, Thierry, Candace Ho, Y. T., Kaczmarski, Joe A., Gavriilidou, Athina, Chow, Ka Ho, Steer, David L., Goode, Robert J. A., Schittenhelm, Ralf B., Tailhades, Julien, Tosin, Manuela, Challis, Gregory L., Krenske, Elizabeth H., Ziemert, Nadine, Jackson, Colin J., Cryle, Max J.

“…Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines,…”
Get full text

Chemoselective Methionine Labelling of Recombinant Trastuzumab Shows High In Vitro and In Vivo Tumour Targeting by Hashad, Rania A., Jap, Edwina, Casey, Joanne L., Candace Ho, Y. T., Wright, Alexander, Thalmann, Claudia, Sleeman, Mark, Lupton, David W., Hagemeyer, Christoph E., Cryle, Max J., Robert, Remy, Alt, Karen

“…A highly effective 2‐step system for site‐specific antibody modification and conjugation of the monoclonal antibody Herceptin (commercially available under…”
Get full text

Novel chemical probes for the investigation of nonribosomal peptide assembly by Ho, Y T Candace, Leng, Daniel J, Ghiringhelli, Francesca, Wilkening, Ina, Bushell, Dexter P, Kostner, Otto, Riva, Elena, Havemann, Judith, Passarella, Daniele, Tosin, Manuela

“…Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin…”
Get more information

Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway by Zhao, Yongwei, Ho, Y. T. Candace, Tailhades, Julien, Cryle, Max

“…The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core…”
Get full text

A Chemoenzymatic Approach to Investigate Cytochrome P450 Cross-Linking in Glycopeptide Antibiotic Biosynthesis by Ho, Y T Candace, Zhao, Yongwei, Tailhades, Julien, Cryle, Max J

“…Glycopeptide antibiotics (GPAs) are important and medically relevant peptide natural products. In the context of antimicrobial resistance (AMR), understanding…”
Get more information

A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues by Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J., Cryle, Max J.

“…Glycopeptide antibiotics (GPAs) are important antibiotics that are highly challenging to synthesise due to their unique and heavily crosslinked structure…”
Get full text

Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones by Ho, Y. T. Candace, Schittenhelm, Ralf B., Iftime, Dumitrita, Stegmann, Evi, Tailhades, Julien, Cryle, Max J.

“…The glycopeptide antibiotics (GPAs) are a clinically approved class of antimicrobial agents that classically function through the inhibition of bacterial…”
Get full text

Altering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated phenylglycine residues by Voitsekhovskaia, Irina, Ho, Y T Candace, Klatt, Christoph, Müller, Anna, Machell, Daniel L, Tan, Yi Jiun, Triesman, Maxine, Bingel, Mara, Schittenhelm, Ralf B, Tailhades, Julien, Kulik, Andreas, Maier, Martin E, Otting, Gottfried, Wohlleben, Wolfgang, Schneider, Tanja, Cryle, Max, Stegmann, Evi

“…Glycopeptide antibiotics (GPAs) are peptide natural products used as last resort treatments for antibiotic resistant bacterial infections. They are produced by…”
Get full text

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin by Ho, Y. T. Candace, Izoré, Thierry, Kaczmarski, Joe A., Marschall, Edward, Ratnayake, Minuri S., Tailhades, Julien, Steer, David L., Schittenhelm, Ralf B., Tosin, Manuela, Jackson, Colin J., Cryle, Max J.

“…In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides…”
Get full text

A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues by Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J., Cryle, Max J.

“…Glycopeptide antibiotics (GPAs) are important antibiotics that are highly challenging to synthesise due to their unique and heavily crosslinked structure…”
Get full text

Cover Feature: Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones (ChemBioChem 6/2023) by Ho, Y. T. Candace, Schittenhelm, Ralf B., Iftime, Dumitrita, Stegmann, Evi, Tailhades, Julien, Cryle, Max J.

“…Glycopeptide antibiotic (GPA) crosslinking is performed by cytochrome P450 (Oxy) enzymes and is essential for antibiotic activity. Here, we symbolise the…”
Get full text

An in vitro assay to explore condensation domain specificity from non-ribosomal peptide synthesis by Ratnayake, Minuri, Ho, Y T Candace, Jian, Xinyun, Cryle, Max J

“…Non-ribosomal peptide synthesis produces a wide range of bioactive peptide natural products and is reliant on a modular architecture based on repeating…”
Get more information