Search Results - "Ho, Winson S."

Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy by Wu, Zhihao, Ho, Winson S., Lu, Rongze

“…As a multi-functional cellular organelle, mitochondrial metabolic reprogramming is well recognized as a hallmark of cancer. The center of mitochondrial…”
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A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors by Xu, Hui, Li, Zhongyu, Yu, Yue, Sizdahkhani, Saman, Ho, Winson S., Yin, Fangchao, Wang, Li, Zhu, Guoli, Zhang, Min, Jiang, Lei, Zhuang, Zhengping, Qin, Jianhua

“…The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases…”
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Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade by Ho, Winson S., Wang, Herui, Maggio, Dominic, Kovach, John S., Zhang, Qi, Song, Qi, Marincola, Francesco M., Heiss, John D., Gilbert, Mark R., Lu, Rongze, Zhuang, Zhengping

“…Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a serine/threonine phosphatase, could enhance anticancer immunity. However, drugs…”
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LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation by Ho, Winson S., Sizdahkhani, Saman, Hao, Shuyu, Song, Hua, Seldomridge, Ashlee, Tandle, Anita, Maric, Dragan, Kramp, Tamalee, Lu, Rongze, Heiss, John D., Camphausen, Kevin, Gilbert, Mark R., Zhuang, Zhengping, Park, Deric M.

“…Atypical and anaplastic meningiomas (AAM) represent 20% of all meningiomas. They are associated with poor outcomes due to their tendency to recur. While…”
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Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer by Lu, Rongze Olivia, Ho, Winson S

“…Glioblastoma (GBM) is the most common malignant brain cancer. Increasing evidence suggests that mitochondrial dysfunction plays a key role in GBM progression…”
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Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism by Fernandez, Thomas V, Sanders, Stephan J, Yurkiewicz, Ilana R, Ercan-Sencicek, A. Gulhan, Kim, Young-Shin, Fishman, Daniel O, Raubeson, Melanie J, Song, Youeun, Yasuno, Katsuhito, Ho, Winson S.C, Bilguvar, Kaya, Glessner, Joseph, Chu, Su Hee, Leckman, James F, King, Robert A, Gilbert, Donald L, Heiman, Gary A, Tischfield, Jay A, Hoekstra, Pieter J, Devlin, Bernie, Hakonarson, Hakon, Mane, Shrikant M, Günel, Murat, State, Matthew W

“…Background Studies of copy number variation (CNV) have characterized loci and molecular pathways in a range of neuropsychiatric conditions. We analyzed rare…”
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PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages by Ho, Winson S, Mondal, Isha, Xu, Beisi, Das, Oishika, Sun, Raymond, Chiou, Pochin, Cai, Xiaomin, Tahmasebinia, Foozhan, McFadden, Elizabeth, Wu, Caren Yu-Ju, Wu, Zhihao, Matsui, William, Lim, Michael, Meng, Zhipeng, Lu, Rongze Olivia

“…Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists…”
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A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm by Clark, Mary C., Lu, Rongze Olivia, Ho, Winson S., Dias, Matheus Henrique, Bernards, René, Forman, Stephen J.

“…Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic…”
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Neoadjuvant Chemotherapy with Laser Interstitial Thermal Therapy in Central Nervous System Neuroblastoma: Illustrative Case and Literature Review by Chung, Jason E, Iqbal, Omar, Krishnan, Chandra, Harrod, Virginia, Tyler-Kabara, Elizabeth, Lu, Rongze O, Ho, Winson S

“…Primitive neuroectodermal tumors of the central nervous system, or CNS neuroblastoma, are rare neoplasms in children. Recently, methylation profiling enabled…”
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PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma by Mondal, Isha, Das, Oishika, Sun, Raymond, Gao, Jian, Yu, Bohyeon, Diaz, Aaron, Behnan, Jinan, Dubey, Abhishek, Meng, Zhipeng, Eskandar, Emad, Xu, Beisi, Lu, Rongze Olivia, Ho, Winson S

“…Glioblastoma (GBM) is an immunologically "cold" tumor that does not respond to current immunotherapy. Here, we demonstrate a fundamental role for the α-isoform…”
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Bystander Attenuation of Neuronal and Astrocyte Intercellular Communication by Murine Cytomegalovirus Infection of Glia by HO, Winson S. C, VAN DEN POL, Anthony N

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Introduction. Calibrating the utility of laser interstitial thermal therapy in neurosurgery: a once-novel surgical treatment finds it place in the armamentarium by Bollo, Robert J., Ho, Winson S., Strauss, Ido, Ferguson, Sherise D., Menacho, Sarah T.

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New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma by Fang, Francia Y, Rosenblum, Jared S, Ho, Winson S, Heiss, John D

“…Pediatric medulloblastoma (MB) is the most common pediatric brain tumor with varying prognoses depending on the distinct molecular subtype. The four consensus…”
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A propensity score–matched cost-effectiveness analysis of magnetic resonance–guided laser interstitial thermal therapy versus craniotomy for brain tumor radiation necrosis by Chen, Jia-Shu, Haddad, Alexander F., Chung, Jason E., Tang, Oliver Y., Ho, Winson S., Hervey-Jumper, Shawn L., Aghi, Manish K.

“…OBJECTIVE Radiation necrosis is becoming an increasingly prevalent complication in patients with brain tumors given the growing utility of stereotactic…”
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Complex Chiari malformation: using craniovertebral junction metrics to guide treatment by Ho, Winson S.C., Brockmeyer, Douglas L.

“…The complex Chiari, characterized by abnormal craniocervical bony anatomy in addition to Chiari tonsillar herniation, is a relatively recent addition to the…”
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Glioma-Immune Cell Crosstalk in Tumor Progression by Elguindy, Mahmoud, Young, Jacob S, Mondal, Isha, Lu, Rongze O, Ho, Winson S

“…Glioma progression is a complex process controlled by molecular factors that coordinate the crosstalk between tumor cells and components of the tumor…”
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A comparison of the accuracy of fetal MRI and prenatal ultrasonography at predicting lesion level and perinatal motor outcome in patients with myelomeningocele by Sherrod, Brandon A, Ho, Winson S, Hedlund, Alec, Kennedy, Anne, Ostrander, Betsy, Bollo, Robert J

“…Prenatal imaging has several critical roles in the diagnosis and management of myelomeningocele, including specific family counseling and the selection of…”
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MRI-guided laser interstitial thermal therapy using the Visualase system and Navigus frameless stereotaxy in an infant: technical case report by Lee, Jonathan J, Clarke, Dave, Hoverson, Eric, Tyler-Kabara, Elizabeth C, Ho, Winson S

“…Laser interstitial thermal therapy (LITT) is increasingly used as a surgical option for the treatment of epilepsy. Placement of the laser fibers relies on…”
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Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma by Maggio, Dominic, Ho, Winson S., Breese, Rebecca, Walbridge, Stuart, Wang, Herui, Cui, Jing, Heiss, John D., Gilbert, Mark R., Kovach, John S., Lu, Rongze O., Zhuang, Zhengping

“…Purpose Glioblastoma (GBM) carries a dismal prognosis despite standard multimodal treatment with surgery, chemotherapy and radiation. Immune checkpoint…”
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Small posterior fossa in Chiari I malformation affected families is significantly linked to 1q43-44 and 12q23-24.11 using whole exome sequencing by Musolf, Anthony M, Ho, Winson S C, Long, Kyle A, Zhuang, Zhengping, Argersinger, Davis P, Sun, Haiming, Moiz, Bilal A, Simpson, Claire L, Mendelevich, Elena G, Bogdanov, Enver I, Bailey-Wilson, Joan E, Heiss, John D

“…The posterior fossa of the cranium contains the cerebellum and brainstem. Processes that reduce the volume of the posterior fossa squeeze the cerebellum and…”
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